Unlocking Exosome Therapeutics: The Critical Role of Pharmacokinetics in Clinical Applications

Tissue and Cell, Год журнала: 2025, Номер 93, С. 102749 - 102749

Опубликована: Янв. 23, 2025

Язык: Английский

The synergistic role of gut microbiota and RNA in metabolic diseases: mechanisms and therapeutic insights

Frontiers in Microbiology, Год журнала: 2025, Номер 16

Опубликована: Янв. 29, 2025

The gut microbiota plays a pivotal role in human metabolic health by influencing immune responses, digestion, and homeostasis. Recent research highlights the intricate interactions between RNA, especially non-coding RNAs, regulating processes. Dysbiosis of has been linked to disorders such as type 2 diabetes, obesity, metabolic-associated fatty liver disease (MAFLD) heart disease. Microbial metabolites, including short-chain acids (SCFAs), modulate RNA expression, lipid metabolism, glucose regulation, inflammatory responses. Additionally, microRNAs (miRNAs) long RNAs (lncRNAs) serve critical regulators these processes, with emerging evidence showing that gut-derived metabolites affect post-transcriptional gene regulation. This review synthesizes current understanding microbiota-RNA axis its diseases. By exploring molecular mechanisms, particularly how microbiota-derived signals pathways, underscores potential targeting this for therapeutic interventions. Furthermore, it examines dysbiosis leads epigenetic changes m6A methylation, contributing pathogenesis. These insights offer new perspective on prevention treatment diseases, applications personalized medicine.

Язык: Английский

Non-coding RNAs in thoracic disease: Barrett’s esophagus and esophageal adenocarcinoma

Clinica Chimica Acta, Год журнала: 2025, Номер unknown, С. 120242 - 120242

Опубликована: Март 1, 2025

Язык: Английский