American Journal of Psychiatry,
Год журнала:
2021,
Номер
178(10), С. 914 - 920
Опубликована: Сен. 23, 2021
Major
depressive
disorder
is
the
leading
cause
of
disability
worldwide.
Yet,
there
remain
significant
challenges
in
predicting
new
cases
major
depression
and
devising
strategies
to
prevent
disorder.
An
important
first
step
this
process
identifying
risk
factors
for
incidence
depression.
There
accumulating
biological
evidence
linking
insulin
resistance,
another
highly
prevalent
condition,
disorders.
The
objectives
study
were
examine
whether
three
surrogate
measures
resistance
(high
triglyceride-HDL
[high-density
lipoprotein]
ratio;
prediabetes,
as
indicated
by
fasting
plasma
glucose
level;
high
central
adiposity,
measured
waist
circumference)
at
time
enrollment
associated
with
an
increased
rate
incident
over
a
9-year
follow-up
period
assess
onset
these
during
2
years
after
was
predictive
subsequent
period.The
Netherlands
Study
Depression
Anxiety
(NESDA)
multisite
longitudinal
course
consequences
anxiety
disorders
adults.
population
comprised
601
NESDA
participants
(18-65
old)
without
lifetime
history
or
study's
outcome
disorder,
defined
using
DSM-IV
criteria.
Exposure
included
ratio,
level,
circumference.Fourteen
percent
sample
developed
follow-up.
Cox
proportional
hazards
models
that
higher
ratio
positively
(hazard
ratio=1.89,
95%
CI=1.15,
3.11),
levels
ratio=1.37,
CI=1.05,
1.77)
circumference
ratio=1.11
CI=1.01,
1.21).
development
prediabetes
2-year
ratio=2.66,
CI=1.13,
6.27).
adiposity
(cut-point
≥100
cm)
same
not
depression.Three
predicted
among
adults
no
In
addition,
between
visit
These
findings
may
have
utility
evaluating
patients
metabolic
pathology.
Acta Psychiatrica Scandinavica,
Год журнала:
2017,
Номер
135(5), С. 373 - 387
Опубликована: Янв. 25, 2017
Objective
To
conduct
a
systematic
review
and
meta‐analysis
of
studies
that
measured
cytokine
chemokine
levels
in
individuals
with
major
depressive
disorder
(
MDD
)
compared
to
healthy
controls
HC
s).
Method
The
PubMed/MEDLINE,
EMBASE
,
PsycINFO
databases
were
searched
up
until
May
30,
2016.
Effect
sizes
estimated
random‐effects
models.
Result
Eighty‐two
comprising
3212
participants
2798
s
met
inclusion
criteria.
Peripheral
interleukin‐6
IL
‐6),
tumor
necrosis
factor
TNF
)‐alpha,
‐10,
the
soluble
‐2
receptor,
C‐C
ligand
2,
‐13,
‐18,
‐12,
‐1
receptor
antagonist,
2
elevated
patients
s,
whereas
interferon‐gamma
lower
(Hedge's
g
=
−0.477,
P
0.043).
Levels
‐1β,
‐2,
‐4,
‐8,
‐6
sIL
‐6R),
‐5,
CCL
‐3,
‐17,
transforming
growth
factor‐beta
1
not
significantly
altered
s.
Heterogeneity
was
large
I
:
51.6–97.7%),
sources
heterogeneity
explored
(e.g.,
age,
smoking
status,
body
mass
index).
Conclusion
Our
results
further
characterize
cytokine/chemokine
profile
associated
.
Future
are
warranted
elucidate
heterogeneity,
as
well
biosignature
cytokines
secreted
by
other
immune
cells.
This
systematic
review
and
meta-analysis
investigated
the
association
between
consumption
of
ultraprocessed
food
noncommunicable
disease
risk,
morbidity
mortality.
Forty-three
observational
studies
were
included
(N
=
891,723):
21
cross-sectional,
19
prospective,
two
case-control
one
conducted
both
a
prospective
cross-sectional
analysis.
Meta-analysis
demonstrated
was
associated
with
increased
risk
overweight
(odds
ratio:
1.36;
95%
confidence
interval
[CI],
1.23-1.51;
P
<
0.001),
obesity
1.51;
CI,
1.34-1.70;
abdominal
1.49;
1.34-1.66;
0.0001),
all-cause
mortality
(hazard
1.28;
1.11-1.48;
metabolic
syndrome
1.81;
1.12-2.93;
0.015)
depression
in
adults
1.22;
1.16-1.28,
0.001)
as
well
wheezing
1.40;
1.27-1.55;
but
not
asthma
adolescents
1.20;
0.99-1.46;
0.065).
In
addition,
cardiometabolic
diseases,
frailty,
irritable
bowel
syndrome,
functional
dyspepsia
cancer
(breast
overall)
while
also
being
dyslipidaemia
children.
Although
links
some
intermediate
factors
highlighted,
further
are
required
to
more
clearly
define
associations
children
adolescents.
STUDY
REGISTRATION:
Prospero
ID:
CRD42020176752.
The Canadian Journal of Psychiatry,
Год журнала:
2016,
Номер
61(9), С. 510 - 523
Опубликована: Авг. 3, 2016
The
Canadian
Network
for
Mood
and
Anxiety
Treatments
(CANMAT)
conducted
a
revision
of
the
2009
guidelines
by
updating
evidence
recommendations.
scope
2016
remains
management
major
depressive
disorder
(MDD)
in
adults,
with
target
audience
psychiatrists
other
mental
health
professionals.Using
question-answer
format,
we
systematic
literature
search
focusing
on
reviews
meta-analyses.
Evidence
was
graded
using
CANMAT-defined
criteria
level
evidence.
Recommendations
lines
treatment
were
based
quality
clinical
expert
consensus.
This
section
is
first
six
articles.In
Canada,
annual
lifetime
prevalence
MDD
4.7%
11.3%,
respectively.
represents
second
leading
cause
global
disability,
high
occupational
economic
impact
mainly
attributable
to
indirect
costs.
DSM-5
disorders
remain
relatively
unchanged,
but
dimensions
(sleep,
cognition,
physical
symptoms)
may
have
implications
depression
management.
e-Mental
increasingly
used
support
self-management
MDD.
In
2-phase
(acute
maintenance)
model,
specific
goals
address
symptom
remission,
functional
recovery,
improved
life,
prevention
recurrence.The
burden
attributed
high,
whether
from
individual
distress,
relationship
impairment,
reduced
or
societal
cost.
Applying
core
principles
care,
including
comprehensive
assessment,
therapeutic
alliance,
self-management,
evidence-informed
treatment,
measurement-based
will
optimize
clinical,
outcomes
Frontiers in Neuroscience,
Год журнала:
2019,
Номер
12
Опубликована: Янв. 13, 2019
Cross-talk
between
adipose
tissue
and
central
nervous
system
(CNS)
underlies
the
increased
risk
of
obese
people
to
develop
brain
diseases
such
as
cognitive
mood
disorders.
Detailed
mechanisms
for
how
peripheral
changes
caused
by
accumulation
in
obesity
impact
CNS
cause
dysfunction
are
poorly
understood.
Adipokines
a
large
group
substances
secreted
white
regulate
wide
range
homeostatic
processes
including,
but
not
limited
to,
energy
metabolism
immunity.
Obesity
is
characterized
generalized
change
levels
circulating
adipokines
due
abnormal
tissue.
Altered
adipokine
underlie
complications
well
development
obesity-related
comorbidities
type
2
diabetes,
cardiovascular
neurodegenerative
diseases.
Here,
we
review
literature
role
key
mediators
communication
periphery
health
disease.
We
will
focus
on
actions
leptin
adiponectin,
two
most
abundant
studied
adipokines,
brain,
with
particular
emphasis
altered
signaling
these
may
lead
augmented
Alzheimer's
A
better
understanding
biology
disorders
prove
major
relevance
diagnostic,
prevention
therapy.
Brain Sciences,
Год журнала:
2017,
Номер
7(11), С. 144 - 144
Опубликована: Окт. 30, 2017
Bipolar
disorder
(BD)
is
strongly
associated
with
immune
dysfunction.
Replicated
epidemiological
studies
have
demonstrated
that
BD
has
high
rates
of
inflammatory
medical
comorbidities,
including
autoimmune
disorders,
chronic
infections,
cardiovascular
disease
and
metabolic
disorders.
Cytokine
low-grade
inflammation
further
increases
in
pro-inflammatory
cytokine
levels
during
mood
episodes.
Several
mechanisms
been
identified
to
explain
the
bidirectional
relationship
between
Key
include
cytokine-induced
monoamine
changes,
increased
oxidative
stress,
pathological
microglial
over-activation,
hypothalamic-pituitary-adrenal
(HPA)
axis
alterations
microbiome-gut-brain
sleep-related
changes.
The
inflammatory-mood
pathway
presents
several
potential
novel
targets
treatment
BD.
proof-of-concept
clinical
trials
shown
a
positive
effect
anti-inflammatory
agents
BD;
however,
research
needed
determine
utility
these
treatments.
Immune
dysfunction
likely
only
play
role
subset
patients
as
such,
future
should
also
strive
identify
which
specific
group(s)
may
benefit
from
