Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy

Neuroscience & Biobehavioral Reviews, Год журнала: 2017, Номер 117, С. 26 - 64

Опубликована: Июль 28, 2017

Язык: Английский

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Prenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology—A global perspective

Development and Psychopathology, Год журнала: 2018, Номер 30(3), С. 843 - 854

Опубликована: Авг. 1, 2018

There is clear evidence that the mother's stress, anxiety, or depression during pregnancy can alter development of her fetus and child, with an increased risk for later psychopathology. We are starting to understand some underlying mechanisms including role placenta, gene-environment interactions, epigenetics, specific systems hypothalamic-pituitary-adrenal axis cytokines. In this review we also consider how these effects may be different, potentially exacerbated, in different parts world. many reasons elevated prenatal as communities at war. raised pregnancy-specific anxiety high levels maternal infant death. interpersonal violence (in Afghanistan 90.2% women thought "wife beating" was justified compared 2.0% Argentina). interactions nutritional deficiencies extremes temperature. Prenatal stress alters microbiome, differ countries. Genetic differences ethnic groups make more vulnerable resilient on child neurodevelopment. Most research questions has been predominantly Caucasian samples from high-income It now time about psychopathology, both social biological differences, rest

Язык: Английский

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Mental health of pregnant women during the COVID-19 pandemic: A longitudinal study

Psychiatry Research, Год журнала: 2020, Номер 295, С. 113567 - 113567

Опубликована: Ноя. 11, 2020

Язык: Английский

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A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches

Translational Psychiatry, Год журнала: 2021, Номер 11(1)

Опубликована: Фев. 19, 2021

Childhood maltreatment is a major risk factor for chronic and severe mental physical health problems across the lifespan. Increasing evidence supports hypothesis that associated with epigenetic changes may subsequently serve as mechanisms of disease. The current review uses systematic approach to identify summarize literature related childhood alterations in DNA methylation humans. A total 100 empirical articles were identified our research published prior or during March 2020, including studies focused on candidate genes leveraged epigenome-wide data both children adults. Themes arising from literature, consistent inconsistent patterns results, are presented. Several directions future research, important methodological considerations study design, discussed. Taken together, underscores complexity transactions between environment biology development.

Язык: Английский

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Trajectories of maternal depressive symptoms during pregnancy and the first 12 months postpartum and child externalizing and internalizing behavior at three years

PLoS ONE, Год журнала: 2018, Номер 13(4), С. e0195365 - e0195365

Опубликована: Апрель 13, 2018

Background Most evidence of the association between maternal depression and children’s development is limited by being cross-sectional. To date, few studies have modelled trajectories depressive symptoms from pregnancy through early postpartum years examined their with social emotional behavior functioning in preschool children. The objectives this study were to: 1) identify distinct groups women defined across four time points mid-pregnancy to one year postpartum; 2) examine associations these child internalizing externalizing behaviors. Methods We analyzed data All Our Families (AOF) study, a large, population based cohort mother-child dyads Alberta, Canada. AOF an ongoing designed investigate relationships prenatal life period outcomes for children mothers. Maternal assessed using Edinburgh Postnatal Depression Scale. Children’s behavioral at age 3 was Behavior Scales developed Canadian National Longitudinal Survey Children Youth. latent class analysis conducted women’s 1 postpartum. used multivariable logistic regression assess relationship behavior, while adjusting other significant maternal, psychosocial factors. Results 1983 participants met eligibility criteria. identified symptoms: low level (64.7%); (10.9%); subclinical (18.8%); persistent high (5.6%). In models, proportion elevated highest whose mothers had symptoms, followed moderate (early trajectories) lowest minimal symptoms. After accounting demographic, factors, hyperactivity/inattention, physical aggression (subclinical trajectory only) separation anxiety remained significant. Conclusion These findings suggest both behaviors are associated prolonged There good case need move beyond overly simplistic clinical cutoff approaches depressed/not depressed screening perinatal depression. Women levels be identified, provided evidence-based treatment, monitored repeat improve mental health reduce risk negative on social-emotional development.

Язык: Английский

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Sex Differences in Vulnerability to Prenatal Stress: a Review of the Recent Literature

Current Psychiatry Reports, Год журнала: 2018, Номер 20(11)

Опубликована: Сен. 18, 2018

Язык: Английский

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Maternal psychological distress during pregnancy and childhood health outcomes: a narrative review

Journal of Developmental Origins of Health and Disease, Год журнала: 2018, Номер 10(3), С. 274 - 285

Опубликована: Окт. 31, 2018

Abstract Maternal psychological distress is common in pregnancy and may influence the risk of adverse outcomes children. Psychological cause a suboptimal intrauterine environment leading to growth developmental adaptations fetus child. In this narrative review, we examined maternal during on fetal child cardiometabolic, respiratory, atopic neurodevelopment-related health outcomes. We discussed these findings from an epidemiological life course perspective provided recommendations for future studies. The literature field extensive shows that exposure stress associated with multiple Because important potential modifiable factor pregnancy, it should be target prevention strategies order optimize health. Future studies use innovative designs address issue causality.

Язык: Английский

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Atypical lateralization in neurodevelopmental and psychiatric disorders: What is the role of stress?

Cortex, Год журнала: 2020, Номер 125, С. 215 - 232

Опубликована: Янв. 16, 2020

Язык: Английский

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Contrasting effects of acute and chronic stress on the transcriptome, epigenome, and immune response of Atlantic salmon

Epigenetics, Год журнала: 2018, Номер 13(12), С. 1191 - 1207

Опубликована: Дек. 2, 2018

Stress experienced during early life may have lasting effects on the immune system, with impacts health and disease dependent nature duration of stressor. The epigenome is especially sensitive to environmental stimuli represents a potential mechanism through which stress cause long-lasting effects. However, extent responds differently chronic vs acute stressors unclear, for non-mammalian species. We examined (cold-shock embryogenesis) (absence tank enrichment larval-stage) global gene expression (using RNA-seq) DNA methylation RRBS) in gills Atlantic salmon (Salmo salar) four months after hatching. Chronic induced pronounced transcriptional differences, while caused few both contrasting changes methylome. Crucially, we found that enhanced response pathogenic challenge (bacterial lipopolysaccharide, LPS), suppressed it. identified stress-induced promoter gene-body were associated altered small proportion immune-related genes, evidence wider epigenetic regulation within signalling pathways involved response. Our results suggest can affect immuno-competence mechanisms, highlight markedly different larval embryonic stress. This knowledge could be used harness stimulatory immunity, paving way improved management conditioning.

Язык: Английский

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Epigenetic responses to heat: From adaptation to maladaptation

Experimental Physiology, Год журнала: 2022, Номер 107(10), С. 1144 - 1158

Опубликована: Апрель 12, 2022

New Findings What is the topic of this review? This review outlines history research on epigenetic adaptations to heat exposure. The perspective taken that reflect properties hormesis, whereby low, repeated doses induce adaptation (acclimation/acclimatization); whereas brief, life‐threatening exposures can maladaptive responses. advances does it highlight? mechanisms underlying acclimation/acclimatization comprise specific molecular programmes histones regulate shock proteins transcriptionally and protect organism from subsequent exposures, even after long delays. signalling responses might rely, in part, extensive changes DNA methylation are sustained over time contribute later health challenges. Abstract Epigenetics plays a strong role by producing memory past environmental exposures. Moderate heat, periods time, induces an ‘adaptive’ memory, resulting condition ‘resilience’ future or cross‐tolerance other forms toxic stress. In contrast, intense, such as severe stroke, result ‘maladaptive’ place at risk complications. These cellular memories coded post‐translational modifications nucleosomes and/or methylation. They operate inducing level gene transcription therefore phenotype. adaptive response acclimation functions, facilitating essential exhibits biphasic short programme (maintaining integrity, followed long‐term consolidation). latter accelerates de‐acclimation. Although less studied, stroke appear be long‐lasting near promoter region genes involved with basic cell function. Whether these also encoded histone not yet known. There considerable evidence both inherited, although most comes lower organisms. Future challenges include understanding responsible discovering new ways promote while suppressing all life adapt warming planet.

Язык: Английский

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