Development and Psychopathology,
Год журнала:
2018,
Номер
30(3), С. 807 - 824
Опубликована: Авг. 1, 2018
Decades
of
fetal
programming
research
indicates
that
we
may
be
able
to
map
the
origins
many
physical,
psychological,
and
medical
variations
morbidities
before
birth
child.
While
great
strides
have
been
made
in
identifying
associations
between
prenatal
insults,
such
as
undernutrition
or
psychosocial
stress,
negative
developmental
outcomes,
far
less
is
known
about
how
adaptive
responses
adversity
regulate
developing
phenotype
match
stressful
conditions.
As
application
epigenetic
methods
human
behavior
has
exploded
last
decade,
begun
shed
light
on
role
mechanisms
explaining
conditions
shape
later
susceptibilities
mental
physical
health
problems.
In
this
review,
describe
attempt
integrate
two
dominant
models:
cumulative
stress
model
(a
disease-focused
approach)
match-mismatch
(an
evolutionary-developmental
approach).
conjunction
with
biological
sensitivity
context
theory,
employ
these
models
generate
new
hypotheses
regarding
through
which
postnatal
experiences
program
child
reactivity
and,
turn,
promote
development
versus
maladaptive
phenotypic
outcomes.
We
conclude
by
outlining
priority
questions
future
directions
for
field.
Development and Psychopathology,
Год журнала:
2018,
Номер
30(3), С. 1041 - 1062
Опубликована: Авг. 1, 2018
The
present
review
revisits
three
hypothesized
models
that
potentially
could
explain
how
prenatal
maternal
stress
influences
fetal
development,
birth
outcomes,
and
subsequent
developmental
psychopathology.
These
were
mostly
based
on
animal
models,
new
evidence
for
these
from
human
studies
is
evaluated.
Furthermore,
divergent
trajectories
exposure
to
adversities
offspring
affected
outcomes
are
reviewed,
including
the
comparison
of
with
research
substance
use
malnutrition
during
pregnancy.
Finally,
directions
in
mechanism
underlying
effects
summarized.
While
it
concluded
there
abundant
negative
associations
between
behavioral,
brain,
psychopathological
humans,
no
consistent
specific
mechanisms
or
relation
utero.
Rather,
principles
multifinality
equifinality
best
describe
consequences
offspring,
suggesting
a
generic
vulnerability
different
pathways
psychopathology,
which
complicates
search
mechanisms.
New
promising
provided
get
better
understanding
gets
under
skin
affect
development.
Frontiers in Behavioral Neuroscience,
Год журнала:
2018,
Номер
12
Опубликована: Дек. 6, 2018
Mitochondria
play
a
central
role
in
cellular
energy-generating
processes
and
are
master
regulators
of
cell
life.
They
provide
the
energy
necessary
to
reinstate
sustain
homeostasis
response
stress,
launch
intensive
adaptation
programs
ensure
an
organism's
survival
future
well-being.
By
this
means,
mitochondria
particularly
apt
mediate
brain
programming
by
early-life
stress
serve
at
same
time
as
subcellular
target
response.
With
focus
on
mitochondria's
integrated
metabolism,
neurosteroid
synthesis,
oxidative
we
review
current
findings
altered
mitochondrial
function
brain,
placenta,
peripheral
blood
cells
following
early
life
stress-dependent
rodents
recent
insights
from
humans
exposed
adversity.
Concluding,
propose
mitochondrion
intersection
point
connecting
programming,
mental
well-being,
potential
site
for
therapeutic
interventions
individuals
severe
stress.
Development and Psychopathology,
Год журнала:
2018,
Номер
30(3), С. 807 - 824
Опубликована: Авг. 1, 2018
Decades
of
fetal
programming
research
indicates
that
we
may
be
able
to
map
the
origins
many
physical,
psychological,
and
medical
variations
morbidities
before
birth
child.
While
great
strides
have
been
made
in
identifying
associations
between
prenatal
insults,
such
as
undernutrition
or
psychosocial
stress,
negative
developmental
outcomes,
far
less
is
known
about
how
adaptive
responses
adversity
regulate
developing
phenotype
match
stressful
conditions.
As
application
epigenetic
methods
human
behavior
has
exploded
last
decade,
begun
shed
light
on
role
mechanisms
explaining
conditions
shape
later
susceptibilities
mental
physical
health
problems.
In
this
review,
describe
attempt
integrate
two
dominant
models:
cumulative
stress
model
(a
disease-focused
approach)
match-mismatch
(an
evolutionary-developmental
approach).
conjunction
with
biological
sensitivity
context
theory,
employ
these
models
generate
new
hypotheses
regarding
through
which
postnatal
experiences
program
child
reactivity
and,
turn,
promote
development
versus
maladaptive
phenotypic
outcomes.
We
conclude
by
outlining
priority
questions
future
directions
for
field.
