Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies

Molecular Psychiatry, Год журнала: 2021, Номер 27(1), С. 281 - 295

Опубликована: Июнь 2, 2021

Promotion of good mental health, prevention, and early intervention before/at the onset disorders improve outcomes. However, range peak ages at for are not fully established. To provide robust, global epidemiological estimates age disorders, we conducted a PRISMA/MOOSE-compliant systematic review with meta-analysis birth cohort/cross-sectional/cohort studies, representative general population, reporting any ICD/DSM-mental identified in PubMed/Web Science (up to 16/05/2020) (PROSPERO:CRD42019143015). Co-primary outcomes were proportion individuals before 14, 18, 25, onset, disorder across International Classification Diseases 11 diagnostic blocks. Median specific was additionally investigated. Across 192 studies (n = 708,561) included, 25 34.6%, 48.4%, 62.5%, 14.5 years (k median interquartile (IQR) 11-34). For blocks, as follows: neurodevelopmental disorders: 61.5%, 83.2%, 95.8%, 5.5 21, median=12, IQR 7-16), anxiety/fear-related 38.1%, 51.8%, 73.3%, 73, 17, 9-25), obsessive-compulsive/related 24.6%, 45.1%, 64.0%, 20, 19, 14-29), feeding/eating disorders/problems: 15.8%, 48.1%, 82.4%, 15.5 11, 15-23), conditions specifically associated stress 16.9%, 27.6%, 43.1%, 16, 30, 17-48), substance use disorders/addictive behaviours: 2.9%, 15.2%, 48.8%, 19.5 58, 20-41), schizophrenia-spectrum disorders/primary psychotic states: 3%, 12.3%, 47.8%, 20.5 36, 20-34), personality disorders/related traits: 1.9%, 9.6%, 47.7%, 6, 20-33), mood 2.5%, 11.5%, 34.5%, 79, 31, 21-46). No significant difference emerged by sex, or definition onset. mapped on time continuum, from phobias/separation anxiety/autism spectrum disorder/attention deficit hyperactivity disorder/social anxiety (8-13 years) anorexia nervosa/bulimia nervosa/obsessive-compulsive/binge eating/cannabis (17-22 years), followed schizophrenia, personality, panic alcohol (25-27 finally post-traumatic/depressive/generalized anxiety/bipolar/acute transient (30-35 overlap among groups no clustering. These results inform timing health promotion/preventive/early intervention, updating current system structured around child/adult service schism 18.

Язык: Английский

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Impact of coronavirus syndromes on physical and mental health of health care workers: Systematic review and meta-analysis

Journal of Affective Disorders, Год журнала: 2020, Номер 275, С. 48 - 57

Опубликована: Июнь 24, 2020

Язык: Английский

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Internet Addiction and Related Psychological Factors Among Children and Adolescents in China During the Coronavirus Disease 2019 (COVID-19) Epidemic

Frontiers in Psychiatry, Год журнала: 2020, Номер 11

Опубликована: Сен. 2, 2020

The Coronavirus disease 2019 (COVID-19) is an infectious presenting a major threat to public health. This study aims assess Internet use characteristics and objectively examine the potential psychological factors associated with addiction (IA) during COVID-19 epidemic.A cross-sectional, anonymized, self-reported survey was conducted among Chinese children adolescents aged 6 18 years old. Participants completed questionnaires containing Young's Addiction Test (IAT) Depression, Anxiety, Stress Scale (DASS-21), questions regarding demographic information characteristics.A total of 2050 participants (mean age:12.34 ± 4.67 old, female: 48.44%) were enrolled. Fifty-five (2.68%) met criterion for addictive (IAT≥70), while 684 (33.37%) classified as problematic users (69≥IAT≥40). usage had grown epidemic, including frequency duration recreational use, stay-up use. A linear regression analysis showed female gender (β=-0.091, p<0.001), age (β=0.066, p=0.001), depression (β=0.257, stress (β=0.323, p<0.001) significantly correlated IAT scores (R=0.539, R2 = 0.291, p<0.001).We observed excessive outbreak COVID-19. Age, gender, depression, key affecting IA. Extended family professional support should be considered vulnerable individuals these unprecedented times.

Язык: Английский

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Psychological distress among health professional students during the COVID-19 outbreak

Psychological Medicine, Год журнала: 2020, Номер 51(11), С. 1952 - 1954

Опубликована: Май 11, 2020

Abstract Background Due to the drastic surge of COVID-19 patients, many countries are considering or already graduating health professional students early aid resources. We aimed assess outbreak-related psychological distress and symptoms acute stress reaction (ASR) in characterize individuals with potential need for interventions. Methods conducted a prospective cohort study 1442 at Sichuan University, China. At baseline (October 2019), participants were assessed childhood adversity, stressful life events, internet addiction, family functioning. Using multivariable logistic regression, we examined associations above exposures subsequent ASR response outbreak. Results Three hundred eighty-four (26.63%) demonstrated clinically significant distress, while 160 (11.10%) met criterion probable ASR. Individuals who scored high on both adversity event experiences during past year increased risks (ORs 2.00–2.66) 2.23–3.10), respectively. Moreover, addiction was associated elevated (OR 2.05, 95% CI 1.60–2.64) 2.15, 1.50–3.10). By contrast, good functioning decreased 0.43, 0.33–0.55) 0.48, 0.33–0.69). All independent distress. Conclusions Our findings suggest that related burden common among students. Extended support should be considered vulnerable these unprecedented times.

Язык: Английский

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Risk and protective factors for mental disorders beyond genetics: an evidence‐based atlas

World Psychiatry, Год журнала: 2021, Номер 20(3), С. 417 - 436

Опубликована: Сен. 9, 2021

Decades of research have revealed numerous risk factors for mental disorders beyond genetics, but their consistency and magnitude remain uncer­tain. We conducted a “meta‐umbrella” systematic synthesis umbrella reviews, which are reviews meta‐analyses individual studies, by searching international databases from inception to January 1, 2021. included on non‐purely genetic or protective any ICD/DSM disorders, applying an established classification the credibility evidence: class I (convincing), II (highly suggestive), III (suggestive), IV (weak). Sensitivity analyses were prospective studies test temporality (reverse causation), TRANSD criteria applied transdiagnosticity factors, A Measurement Tool Assess Systematic Reviews (AMSTAR) was employed address quality meta‐analyses. Fourteen eligible retrieved, summarizing 390 1,180 associations between putative disorders. 176 evidence associations, relating 142 risk/protective factors. The most robust (class II, designs) 21. For dementia, they type 2 diabetes mellitus (risk ratio, RR 1.54 2.28), depression (RR 1.65 1.99) low frequency social contacts (RR=1.57). opioid use factor tobacco smoking (odds OR=3.07). non‐organic psychotic clinical high state psychosis (OR=9.32), cannabis (OR=3.90), childhood adversities (OR=2.80). depressive widowhood (RR=5.59), sexual dysfunction (OR=2.71), three (OR=1.99) four‐five (OR=2.06) metabolic physical (OR=1.98) (OR=2.42) abuse, job strain (OR=1.77), obesity (OR=1.35), sleep disturbances (RR=1.92). autism spectrum disorder, maternal overweight pre/during pregnancy (RR=1.28). attention‐deficit/hyperactivity disorder (ADHD), pre‐pregnancy (OR=1.63), during (OR=1.60), (OR=1.28). Only one detected: activity (hazard HR=0.62) Alzheimer’s disease. In all, 32.9% quality, 48.9% medium 18.2% quality. Transdiagnostic I‐III mostly involved in early neurodevelopmental period. evidence‐based atlas key identified this study represents benchmark advancing characterization research, expanding intervention preventive strategies

Язык: Английский

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Prevalence of Internet-based addictive behaviors during COVID-19 pandemic: a systematic review

Journal of Addictive Diseases, Год журнала: 2021, Номер 39(4), С. 468 - 488

Опубликована: Март 22, 2021

With the outbreak of COVID-19 worldwide pandemic, many countries have imposed lockdowns which caused an increase in Internet use. As large-scale disasters may impact on addictions, a review Internet-based addictive behaviors seems necessary. The goals this are to find whether increased during pandemic and define main reasons for increase. systematic search was conducted Google Scholar, Science Direct, PsycINFO, PubMed October 2020, determine current evidence observations concerning amid COVID-19. Studies were included if they considered pandemic. We used all names coronavirus 2 (SARS-CoV2 previously 2019 nCoV), name disease (COVID-19), common behaviors, namely addiction, online gaming disorder, gambling pornography use, smartphone use disorder. study design is PEOs, finding individuals' exposure has behaviors. quality studies assessed independently by two authors using Grading Recommendations Assessment, Development, Evaluation (GRADE) approach. articles found proved mostly due financial hardships, isolation, problematic substance mental health issues such as depression, anxiety, stress. Effective interventions should be scaled up prevent reduce well accessible guidelines, particularly adolescents.

Язык: Английский

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metaumbrella: the first comprehensive suite to perform data analysis in umbrella reviews with stratification of the evidence

BMJ Mental Health, Год журнала: 2023, Номер 26(1), С. e300534 - e300534

Опубликована: Фев. 1, 2023

Objective Umbrella reviews are a new form of literature review that summarises the strength and/or quality evidence from all systematic and meta-analyses conducted on broad topic. This type thus provides an exhaustive examination vast body information, providing highest synthesis knowledge. A critical umbrella is recalculating meta-analytic estimates within uniform framework to allow consistent stratification. To our best knowledge, there no comprehensive package or software conduct reviews. Methods The R metaumbrella accomplishes this aim by building three core functions (1) automatically perform required calculations in (including but not limited pairwise meta-analyses), (2) stratify according various classification criteria (3) generate visual representation results. In addition, allows flexible inputs for each meta-analysis analysed (eg, means plus SD, effect size estimate CI) customisation stratification following Ioannidis, algorithmic GRADE personalised classification). Results first range facilities with evidence. Conclusion facilitate use package, even researchers unfamiliar R, we also provide JAMOVI module open-access, browser-based graphical interface few mouse clicks.

Язык: Английский

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Experiences of nursing students as healthcare aid during the COVID-19 pandemic in Spain: A phemonenological research study

Nurse Education Today, Год журнала: 2020, Номер 97, С. 104711 - 104711

Опубликована: Дек. 17, 2020

Язык: Английский

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Risk factors for eating disorders: an umbrella review of published meta-analyses

Brazilian Journal of Psychiatry, Год журнала: 2020, Номер 43(3), С. 314 - 323

Опубликована: Сен. 28, 2020

Objective: To grade the evidence about risk factors for eating disorders (anorexia nervosa, bulimia and binge disorder) with an umbrella review approach. Methods: This was a systematic of observational studies on published in PubMed/PsycInfo/Embase until December 11th, 2019. We recalculated random-effect meta-analyses, heterogeneity, small-study effect, excess significance bias 95% prediction intervals, grading significant (p < 0.05) from convincing to weak according established criteria. Quality assessed Assessment Multiple Systematic Reviews 2 (AMSTAR-2) tool. Results: Of 2,197 nine were included, providing 50 factors, 29,272 subjects disorders, 1,679,385 controls. Although no association supported by evidence, highly suggestive between childhood sexual abuse nervosa (k = 29, 1,103 cases 8,496 controls, OR, 2.73, 95%CI 1.96-3.79, p 2.1 x 10-9, AMSTAR-2 moderate quality) appearance-related teasing victimization any disorder 10, 1,341 3,295 OR 2.91, 2.05-4.12, 1.8x10-9, quality). Suggestive, weak, or 11, 8 associations, respectively. Conclusions: The most credible indicates that early traumatic stressful events are disorders. Larger collaborative prospective cohort needed identify particularly anorexia nervosa.

Язык: Английский

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The Role of Social Determinants in Mental Health and Resilience After Disasters: Implications for Public Health Policy and Practice

Frontiers in Public Health, Год журнала: 2021, Номер 9

Опубликована: Май 19, 2021

In this general literature review, we will explore the impacts and contribution of social determinants to mental health resiliency following both natural man-made disasters. Natural disasters, such as wildfires, earthquakes, tsunamis, hurricanes, well civil wars, have been known inflict significant damage victims. paper, mainly some most studied vulnerability protective determinant factors gender, age, ethnicity, socials support socioeconomic status for in survivors Several other possible previous trauma, childhood abuse, family psychiatric history, subsequent life stress that were explored by studies also discussed. We conducted a search major scientific databases, using keywords as: health, determinants, terrorist attacks, resilience. discuss implications public policy practice.

Язык: Английский

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