Loneliness, epigenetic age acceleration, and chronic health conditions.

Psychology and Aging, Год журнала: 2024, Номер 39(4), С. 337 - 349

Опубликована: Апрель 18, 2024

Having associations with a range of adverse physical health outcomes including mortality, loneliness is increasingly recognized as pressing public concern, but the mechanisms studied to date do not yet explain all loneliness-related risk. We sought evaluate whether epigenetic influences on DNA methylation could help relationship between and health. To so, we first estimated age acceleration (EAA) in subsample participants study midlife United States (

Язык: Английский

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The loneliness factor in eating disorders: Implications for psychopathology and biological signatures

Comprehensive Psychiatry, Год журнала: 2024, Номер 132, С. 152493 - 152493

Опубликована: Апрель 28, 2024

Eating disorders (ED) are severe psychiatric conditions. While the biological consequences of EDs well established, including an increase in inflammatory biomarkers, influence psychological factors, such as loneliness, has only recently gained attention research. Loneliness been associated with more psychopathology ED patients, while its association biomarkers explored general population. For these reasons, we aimed to investigate any possible associations between features, trauma, and loneliness people ED.

Язык: Английский

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The association of loneliness and social isolation with multimorbidity over 14 years in older adults in England: A population-based cohort study

Archives of Gerontology and Geriatrics, Год журнала: 2025, Номер 131, С. 105763 - 105763

Опубликована: Янв. 18, 2025

Язык: Английский

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Social isolation, loneliness, and their joint effects on cognitive decline and incident Alzheimer's disease: Findings from the Chicago health and aging project

The Journal of Prevention of Alzheimer s Disease, Год журнала: 2025, Номер unknown, С. 100046 - 100046

Опубликована: Янв. 1, 2025

There has been contradictory evidence on the prospective associations between social isolation/loneliness (SI/L) and cognitive decline (CD). is also a scarcity of large diverse population-based cohort studies examining SI/L that have confirmed clinical diagnoses Alzheimer's Disease (AD). Notably, beyond individual associations, whether effects compound accelerate CD incident AD are not known. We hypothesized SI L, independently, would be associated with to similar extent, association higher in lonely older adults. Prospective study. Urban Chicago areas. analyzed data Health Aging Project (CHAP), which comprised 7,760 biracial community-dwelling adults [mean age (standard deviation (SD))=72.3 (6.3); 64 % Black & 63 women; mean (SD) follow-up=7.9 (4.3) years]. NA MEASUREMENTS: Linear mixed logistic regression models were used regress separately index/L. index L significantly CD, one-point increase beta estimate (SE, p-value) = -0.002 (0.001,0.022) -0.012 (0.003,<0.001), respectively. Given ranges from 0 5 1, they had effect sizes. Similarly, there significant AD, odds ratio (95 CI, 1.183 (1.016-1.379,0.029), 2.117 (1.227-3.655,0.006). When stratified by loneliness status, compared who isolated lonely, reported being socially experienced accelerated -0.003 (0.001,0.004), despite no increased AD. appeared most vulnerable CD. These findings suggest specific at-risk subgroup for future targeted interventions improve health.

Язык: Английский

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Interplay between social isolation and loneliness and chronic systemic inflammation during the COVID-19 pandemic in Japan: Results from U-CORONA study

Brain Behavior and Immunity, Год журнала: 2021, Номер 94, С. 51 - 59

Опубликована: Март 9, 2021

Язык: Английский

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