Prefrontal cortex, amygdala, and threat processing: implications for PTSD

Neuropsychopharmacology, Год журнала: 2021, Номер 47(1), С. 247 - 259

Опубликована: Сен. 20, 2021

Abstract Posttraumatic stress disorder can be viewed as a of fear dysregulation. An abundance research suggests that the prefrontal cortex is central to processing—that is, how fears are acquired and strategies regulate or diminish responses. The current review covers foundational on threat acquisition extinction in nonhuman animals, healthy humans, patients with posttraumatic disorder, through lens involvement these processes. Research harnessing advances technology further probe role processes, such use optogenetics rodents brain stimulation will highlighted, well other regulation approaches relevant treatment involve cortex, namely cognitive avoidance/active coping. Despite large body translational research, many questions remain unanswered remains difficult treat. We conclude by outlining future directions related processing implications for disorder.

Язык: Английский

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Amygdala-prefrontal connectivity during emotion regulation: A meta-analysis of psychophysiological interactions

Neuropsychologia, Год журнала: 2021, Номер 153, С. 107767 - 107767

Опубликована: Янв. 29, 2021

Given the importance of emotion regulation as a transdiagnostic factor in development psychopathology, myriad neuroimaging studies has investigated its neural underpinnings. However, single usually provide limited insight into function specific brain regions. Hence, to better understand interaction between key regions involved generation and regulation, we performed coordinate-based meta-analysis on functional magnetic resonance imaging (fMRI) that examined regulation-modulated connectivity amygdala using psychophysiological (PPI) analysis. We analyzed fifteen PPI activation likelihood estimation (ALE) algorithm. Investigating independent strategy goal revealed convergent left ventrolateral prefrontal cortex (vlPFC), which was primarily driven by implementing reappraisal strategy. A more focused analysis testing for effective coupling during down-regulation emotions specifically right dorsolateral (dlPFC), dorsomedial (dmPFC). These have been implicated regulatory processes such working memory language attribution mental states Our findings suggest not only dynamic modulation generative systems cognitive control emotions, but also highlight robustness task-modulated prefrontal-amygdala coupling, thereby informing neurally-derived models regulation.

Язык: Английский

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A short review on emotion processing: a lateralized network of neuronal networks

Brain Structure and Function, Год журнала: 2021, Номер 227(2), С. 673 - 684

Опубликована: Июль 3, 2021

Emotions are valenced mental responses and associated physiological reactions that occur spontaneously automatically in response to internal or external stimuli, can influence our behavior, themselves be modulated a certain degree voluntarily by stimuli. They subserved large-scale integrated neuronal networks with epicenters the amygdala hippocampus, which overlap anterior cingulate cortex. Although emotion processing is accepted as being lateralized, specific role of each hemisphere remains an issue controversy, two major hypotheses have been proposed. In right-hemispheric dominance hypothesis, all emotions thought processed right hemisphere, independent their valence emotional feeling processed. lateralization left dominant for positively stimuli inducing approach behaviors, whereas negatively withdrawal would hemisphere. More recent research points at existence multiple interrelated networks, component generation, i.e., its perception, regulation. It has thus proposed move from supporting overall hemispheric specialization toward dynamic models incorporating do not necessarily share same patterns.

Язык: Английский

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Relations between emotion regulation strategies and affect in daily life: A systematic review and meta-analysis of studies using ecological momentary assessments

Neuroscience & Biobehavioral Reviews, Год журнала: 2022, Номер 139, С. 104747 - 104747

Опубликована: Июнь 16, 2022

Emotion regulation (ER) is a central target in the study of psychological and neurobiological processes emotions for numerous disorders. Ecological momentary assessments, overcoming retrospective self-reports, allow better understanding relation between use ER strategies daily life affective experiences. A systematic review meta-analyses studies testing these relations through experience sampling methods (ESM) diaries were conducted. ESM showed significant large effect sizes contemporaneous negative affect (NA) rumination, suppression, worry, both prospective positive (PA) reappraisal; medium NA PA distraction; small size suppression. Daily diary rumination acceptance, problem-solving; reappraisal. These findings shed light on temporal experiences highlight conceptual methodological limitations field.

Язык: Английский

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Anxiety and the Neurobiology of Temporally Uncertain Threat Anticipation

Journal of Neuroscience, Год журнала: 2020, Номер 40(41), С. 7949 - 7964

Опубликована: Сен. 21, 2020

When extreme, anxiety—a state of distress and arousal prototypically evoked by uncertain danger—can be debilitating. Uncertain anticipation is a shared feature situations that elicit signs symptoms anxiety across psychiatric disorders, species, assays. Despite the profound significance for human health wellbeing, neurobiology uncertain-threat remains unsettled. Leveraging paradigm adapted from animal research optimized fMRI signal decomposition, we examined neural circuits engaged during temporally certain threat in 99 men women. Results revealed systems recruited are anatomically colocalized frontocortical regions, extended amygdala, periaqueductal gray. Comparison conditions demonstrated this circuitry can fractionated, with regions showing relatively stronger engagement threat, amygdala reverse pattern. Although there widespread agreement bed nucleus stria terminalis dorsal amygdala—the two major subdivisions amygdala—play critical role orchestrating adaptive responses to potential danger, their precise contributions have remained contentious. Follow-up analyses these show statistically indistinguishable anticipation. These observations provide framework conceptualizing fear, understanding functional neuroanatomy humans, accelerating development more effective intervention strategies pathological anxiety. SIGNIFICANCE STATEMENT Anxiety—an emotion associated harm—has public health, yet underlying unclear. novel neuroimaging large sample, identify core circuit responsive both anticipation, fractionated into bias one kind or other. The occupies center stage neuropsychiatric models anxiety, but its architecture has Here demonstrate threat. Collectively, indicate need revise how think about fear.

Язык: Английский

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Event-related potential studies of emotion regulation: A review of recent progress and future directions

International Journal of Psychophysiology, Год журнала: 2022, Номер 176, С. 73 - 88

Опубликована: Март 25, 2022

Язык: Английский

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The role of dlPFC laterality in the expression and regulation of anxiety

Neuropharmacology, Год журнала: 2022, Номер 224, С. 109355 - 109355

Опубликована: Ноя. 26, 2022

Anxiety disorders are the most common mental health disorder. Therefore, elucidating brain mechanisms implicated in anxiety is important avenue for developing novel treatments and improving care. The dorsolateral prefrontal cortex (dlPFC) thought to be critically involved working memory processes (i.e. maintenance, manipulation, suppression, etc.). In addition, there evidence that this region regulation. However, it unclear how related dlPFC contribute Furthermore, we know laterality plays an role processing, however no current model of mediated regulation accounts potential effects. To address gap, propose a framework where contributes emotion via processing. According framework, fundamental process executed by dlPFC. domain content differs across left right dlPFC, with sensitive primarily verbal content, non-verbal (affective content). Critically, allow both retention suppression affective information overall net effect processing on mood will depend balance valence being processed (positive vs. negative), (verbal non-verbal). If accurate, proposed predicts effects neuromodulation targeting may dependent upon context during which stimulation presented. This article part Special Issue 'Fear, PTSD'.

Язык: Английский

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Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders

Neuronal Signaling, Год журнала: 2023, Номер 7(4)

Опубликована: Окт. 27, 2023

Abstract Emotion dysregulation (ED) describes a difficulty with the modulation of which emotions are felt, as well when and how these experienced or expressed. It is focal overarching symptom in many severe prevalent neuropsychiatric diseases, including bipolar disorders (BD), attention deficit/hyperactivity disorder (ADHD), borderline personality (BPD). In all disorders, ED can manifest through symptoms depression, anxiety, affective lability. Considering symptomatic similarities between BD, ADHD, BPD, transdiagnostic approach promising lens investigation. Mounting evidence supports role peripheral inflammatory markers stress multifactorial aetiology physiopathology BPD. Of note, neural circuits that regulate appear particularly vulnerable to insults inflammation, impact neuroimmune milieu central nervous system. Thus far, few studies have examined link inflammation To our knowledge, no specific work has provided critical comparison results from disorders. fill this gap literature, we review known associations mechanisms linking general, clinically, BD. Our narrative begins an examination routes followed by discussion disorder-specific accounting for methodological limitations relevant confounding factors. Finally, critically discuss both correspondences discrepancies comment on potential vulnerability therapeutic interventions.

Язык: Английский

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A systems identification approach using Bayes factors to deconstruct the brain bases of emotion regulation

Nature Neuroscience, Год журнала: 2024, Номер 27(5), С. 975 - 987

Опубликована: Март 22, 2024

Язык: Английский

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Neural underpinnings of individual differences in emotion regulation: A systematic review

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 162, С. 105727 - 105727

Опубликована: Май 15, 2024

This review synthesises individual differences in neural processes related to emotion regulation (ER). It comprises self-reported and physiological success, ER-related traits, demographic variables, assess their correlation with brain activation during ER tasks. Considering region-of-interest (ROI) whole-brain analyses, the incorporated data from 52 functional magnetic resonance imaging studies. Results can be summarized as follows: (1) Self-reported success (assessed by emotional state ratings after regulation) traits questionnaires) correlated activity lateral prefrontal cortex. (2) Amygdala only ROI while it was associated analyses. (3) For measures, there no systematic overlap effects reported across In showing that traced back of regions reactivity (amygdala) cognitive control (lateral cortex), our findings inform prospective personalised intervention models.

Язык: Английский

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