International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(23), С. 16990 - 16990
Опубликована: Ноя. 30, 2023
γ-Aminobutyric
acid
aminotransferase
(GABA-AT)
is
a
pyridoxal
5'-phosphate
(PLP)-dependent
enzyme
that
degrades
γ-aminobutyric
(GABA)
in
the
brain.
GABA
an
important
inhibitory
neurotransmitter
plays
neurological
roles
Therefore,
GABA-AT
drug
target
regulates
levels.
Novel
and
potent
development
to
inhibit
still
very
challenging
task.
In
this
study,
we
aimed
devise
novel
inhibitors
against
using
computer-aided
design
(CADD)
tools.
Since
crystal
structure
of
human
was
not
yet
available,
utilized
homologous
derived
from
our
previously
published
paper.
To
identify
highly
compounds
relative
vigabatrin,
FDA-approved
GABA-AT,
developed
pharmacophore
analysis
protocol
for
530,000
Korea
Chemical
Bank
(KCB)
selected
top
50
further
screening.
Preliminary
biological
carried
out
these
16
were
assessed.
Subsequently,
molecular
docking,
dynamics
(MD)
simulations,
binding
free
energy
calculations
out.
results,
four
predicted
compounds,
A07,
B07,
D08,
H08,
found
be
evaluated
by
activity
assay
confirm
results
inhibition
assay.
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Март 27, 2024
Abstract
Parkinson's
disease
(PD)
is
a
progressive
neurodegenerative
as
result
of
the
degeneration
dopaminergic
neurons
in
substantia
nigra
pars
compacta
(SNpc).
The
fundamental
features
PD
are
motor
and
non-motor
symptoms.
symptoms
develop
due
to
disruption
neurotransmitters
other
such
γ-aminobutyric
acid
(GABA).
potential
role
GABA
neuropathology
concerning
was
not
precisely
discussed.
Therefore,
this
review
intended
illustrate
possible
regarding
pathway
essential
regulating
inhibitory
tone
prevent
excessive
stimulation
cerebral
cortex.
Degeneration
linked
with
reducing
GABAergic
neurotransmission.
Decreasing
activity
promotes
mitochondrial
dysfunction
oxidative
stress,
which
highly
related
neuropathology.
Hence,
restoring
by
agonists
may
attenuate
progression
dysregulation
SNpc
contributes
developing
Besides,
also
pathway,
amelioration
reduce
In
conclusion,
deregulation
might
be
intricate
Improving
novel,
beneficial
approach
control
Epilepsia,
Год журнала:
2023,
Номер
64(8), С. 1975 - 1990
Опубликована: Май 17, 2023
Epilepsy
is
one
of
the
most
common
neurological
disorders.
Although
many
factors
contribute
to
epileptogenesis,
seizure
generation
mostly
linked
hyperexcitability
due
alterations
in
excitatory/inhibitory
(E/I)
balance.
The
hypothesis
that
reduced
inhibition,
increased
excitation,
or
both
etiology
epilepsy.
Increasing
evidence
shows
this
view
oversimplistic,
and
inhibition
through
depolarizing
γ-aminobutyric
acid
(GABA)
similarly
contributes
epileptogenisis.
In
early
development,
GABA
signaling
depolarizing,
inducing
outward
Cl-
currents
high
intracellular
concentrations.
During
maturation,
mechanisms
action
shift
from
hyperpolarizing,
a
critical
event
during
brain
development.
Altered
timing
associated
with
neurodevelopmental
disorders
Here,
we
consider
different
ways
altered
E/I
balance
discuss
could
be
denominator
underlying
epilepsies.
NeuroImage,
Год журнала:
2023,
Номер
275, С. 120154 - 120154
Опубликована: Май 19, 2023
In
the
human
electroencephalogram
(EEG),
oscillatory
power
co-exist
with
non-oscillatory,
aperiodic
activity.
Although
EEG
analysis
has
traditionally
focused
exclusively
on
power,
recent
investigations
have
shown
that
component
can
distinguish
conscious
wakefulness
from
sleep
and
anesthetic-induced
unconsciousness.
This
study
investigates
of
individuals
in
a
disorder
consciousness
(DOC);
how
it
changes
response
to
exposure
anesthesia;
relates
brain's
information
richness
criticality.
High-density
was
recorded
43
DOC,
16
these
undergoing
protocol
propofol
anesthesia.
The
defined
by
spectral
slope
density.
Our
results
demonstrate
is
more
informative
about
participants'
level
than
component,
especially
for
patients
suffered
stroke.
Importantly,
pharmacologically
induced
change
30
45
Hz
positively
correlated
individual's
pre-anesthetic
consciousness.
loss
information-richness
criticality
associated
component.
During
anesthesia,
distinguished
according
their
3-month
recovery
status.
been
historically
neglected;
this
research
highlights
necessity
considering
measure
assessment
DOC
future
seeks
understand
neurophysiological
underpinnings
Fermentation,
Год журнала:
2025,
Номер
11(2), С. 84 - 84
Опубликована: Фев. 7, 2025
Gamma-aminobutyric
acid
(GABA)
is
becoming
more
well-acknowledged
for
its
ability
to
improve
the
development
performance
of
poultry,
particularly
by
interacting
with
Insulin-like
growth
Factor
1
(IGF-1)
pathway.
This
review
emphasizes
importance
GABA
in
optimizing
poultry
production
thoroughly
examining
biochemical
characteristics,
physiological
roles,
and
molecular
mechanisms
action.
a
crucial
inhibitory
neurotransmitter
that
not
only
regulates
neuronal
excitability
but
also
optimizes
metabolic
processes
critical
growth.
Supplementing
feeds
has
been
shown
enhance
feed
conversion
efficiency,
increase
body
weight,
bolster
immune
function.
The
interplay
between
IGF-1
crucial,
as
modulates
levels
receptor
sensitivity,
promoting
muscle
overall
health.
fermentation
producing
bioavailable
GABA,
presenting
promising
implications
sustainable
farming
practices.
Further
investigation
into
supplementation
strategies
could
lead
improved
healthier
systems.
Metabolites,
Год журнала:
2025,
Номер
15(3), С. 209 - 209
Опубликована: Март 19, 2025
Objectives:
This
study
investigated
the
long-term
effects
of
maternal
undernutrition
on
overall
muscle
metabolism,
growth
performance,
and
characteristics
in
postnatal
offspring
Wagyu
(Japanese
Black)
cattle.
Methods:
cows
were
divided
into
nutrient-adequate
(control,
CNT;
n
=
4,
120%
requirements)
nutrient-restricted
groups
(NR;
4;
60%
requirements),
treated
from
day
35
gestation
until
parturition.
Diets
delivered
basis
crude
protein
requirements,
meeting
100%
80%
dry
matter
requirements
CNT
NR
groups,
respectively.
All
provided
with
same
diet
birth
to
300
days
age
(d).
Longissimus
thoracis
(LM)
samples
collected
offspring.
Results:
The
had
lower
body
weight,
but
their
weight
caught
up
before
weaning.
These
showed
enhanced
efficiency
nutrient
utilization
during
post-weaning
period.
Comprehensive
analyses
metabolites
transcripts
revealed
accumulation
proteinogenic
amino
acid,
asparagine,
LM
at
d,
while
abundance
nicotinamide
adenine
dinucleotide
(NADH)
succinate
reduced.
changes
accompanied
by
decreased
gene
expression
phosphoribosyltransferase
(NAMPT),
NADH:
ubiquinone
oxidoreductase
subunit
A12
(NDUFA12),
NADH
dehydrogenase
5
(ND5),
which
are
essential
for
mitochondrial
energy
production.
Additionally,
exhibited
neurotransmitter,
along
a
higher
proportion
slow-oxidative
myofibers
fast-oxidative
d.
Conclusions:
Offspring
might
suppress
production,
primarily
mitochondria,
conserve
expenditure
synthesis.
findings
suggest
that
programs
thrifty
metabolism
muscle,
effects.
