Hyperactivity in the Hypothalamic-Pituitary-Adrenal Axis: An Invisible Killer for Anxiety and/or Depression in Coronary Artherosclerotic Heart Disease

Journal of Integrative Neuroscience, Год журнала: 2024, Номер 23(12)

Опубликована: Дек. 24, 2024

The coexistence of anxiety or depression with coronary heart disease (CHD) is a significant clinical challenge in cardiovascular medicine. Recent studies have indicated that hypothalamic-pituitary-adrenal (HPA) axis activity could be promising focus understanding and addressing the development treatments for comorbid CHD depression. HPA helps to regulate levels inflammatory factors, thereby reducing oxidative stress damage, promoting platelet activation, stabilizing gut microbiota, which enhance survival regeneration neurons, endothelial cells, other cell types, leading neuroprotective cardioprotective benefits. This review addresses relevance nervous systems, as well latest research advancements regarding its mechanisms action. discussion includes detailed function regulating processes mentioned. Above all, it summarizes therapeutic potential biomarker atherosclerotic combined

Язык: Английский

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The role of maternal exercise on placental, behavioral and genetic alterations induced by prenatal stress

Neurochemistry International, Год журнала: 2022, Номер 158, С. 105384 - 105384

Опубликована: Июль 1, 2022

Язык: Английский

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Transcriptomic profiling of the developing brain revealed cell-type and brain-region specificity in a mouse model of prenatal stress

BMC Genomics, Год журнала: 2023, Номер 24(1)

Опубликована: Фев. 24, 2023

Prenatal stress (PS) is considered as a risk factor for many mental disorders. PS-induced transcriptomic alterations may contribute to the functional dysregulation during brain development. Here, we used RNA-seq explore changes of gene expression in mouse fetal after prenatal exposure chronic unpredictable mild (CUMS).We compared stressed brains controls and identified groups significantly differentially expressed genes (DEGs). GO analysis on up-regulated DEGs revealed enrichment cell cycle pathways, while down-regulated were mostly enriched neuronal pathways related synaptic transmission. We further performed cell-type using published scRNA-seq data from cell-type-specificity up- DEGs, respectively. The highly radial glia, different types neurons. Cell deconvolution showed altered fractions brain, indicating accumulation neuroblast impaired neurogenesis. Moreover, also observed distinct brain-region pattern when mapping onto developing Allen atlas. primarily dorsal forebrain regions including cortical plate hippocampal formation. Surprisingly, found excluded region, but various ventral forebrain, midbrain hindbrain.Taken together, provided an unbiased source whole PS, reported differential vulnerability response environmental insults pregnancy.

Язык: Английский

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Corticosteroids as Selective and Effective Modulators of Glycine Receptors

ACS Chemical Neuroscience, Год журнала: 2023, Номер 14(17), С. 3132 - 3142

Опубликована: Авг. 16, 2023

The mechanism of the negative impact corticosteroids on induction and progress mental illness remains unclear. In this work, we studied effects activity neuronal glycine receptors (GlyR) GABA-A (GABAAR) by measuring chloride current induced application GABA (2 or 5 μM) to isolated cerebellar Purkinje cells (IGABA) (100 pyramidal neurons rat hippocampus (IGly). It was found that corticosterone, 5α-dihydrodeoxycorticosterone, allotetrahydrocorticosterone, cortisol, 17α,21-dihydroxypregnenolone were able accelerate desensitization IGly at physiological concentrations (IC50 values varying from 0.39 0.72 μM). Next, cortisone, 11-deoxycortisol, 11-deoxycorticosterone, 5β-dihydrodeoxycorticosterone, tetrahydrocorticosterone accelerated with IC50 10.3 15.2 μM. Allotetrahydrocorticosterone potentiated IGABA albeit high EC50 (18–23 rest steroids had no effect in range 1–100 Finally, our study has suggested a structural relationship 3β-hydroxyl group/3-oxo group selective modulatory GlyRs contrast 3α-hydroxyl is pivotal for GABAARs. summary, results suggest increased GlyR may contribute brain dysfunction under chronic stress identify further development as modulators GlyRs.

Язык: Английский

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GR/Ahi1 regulates WDR68-DYRK1A binding and mediates cognitive impairment in prenatally stressed offspring

Cellular and Molecular Life Sciences, Год журнала: 2024, Номер 81(1)

Опубликована: Янв. 10, 2024

Язык: Английский

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