Associations of Menstrual Cycle and Progesterone-to-Estradiol Ratio With Alcohol Consumption in Alcohol Use Disorder: A Sex-Separated Multicenter Longitudinal Study

American Journal of Psychiatry, Год журнала: 2024, Номер 181(5), С. 445 - 456

Опубликована: Янв. 10, 2024

Alcohol use disorder (AUD) constitutes a critical public health issue and has sex-specific characteristics. Initial evidence suggests that progesterone estradiol might reduce or increase alcohol intake, respectively. However, there is need for better understanding of how the menstrual cycle in females ratio to males influence patterns individuals with AUD.

Язык: Английский

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GABA-ergic Modulators: New Therapeutic Approaches to Premenstrual Dysphoric Disorder

CNS Drugs, Год журнала: 2023, Номер 37(8), С. 679 - 693

Опубликована: Авг. 1, 2023

Язык: Английский

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Ovarian Hormones Regulate Nicotine Consumption and Accumbens Glutamatergic Plasticity in Female Rats

eNeuro, Год журнала: 2022, Номер 9(3), С. ENEURO.0286 - 21.2022

Опубликована: Май 1, 2022

Abstract Women report greater cigarette cravings during the menstrual cycle phase with higher circulating levels of 17β-estradiol (E2), which is metabolized to estrone (E1). Both E2 and E1 bind estrogen receptors (ERs), have been highly studied in breast, uterus, ovary. Recent studies found that ERs are also located on GABAergic medium spiny neurons (MSNs) within nucleus accumbens core (NAcore). Glutamatergic plasticity NAcore MSNs altered following nicotine use; however, it unknown whether estrogens impact this neurobiological consequence. To test effect use, we ovariectomized (OVX) female rats then underwent self-administration acquisition compared them ovary-intact (sham) rats. The OVX animals received either sesame oil (vehicle), E2, or E1+E2 supplementation for 4 20 d before sessions. While both females readily discriminated levers, consumed less than sham females. Further, neither nor increased consumption back OVX, regardless duration treatment. rendered a potentiated state self-administration, was reversed by systemic Finally, ERα mRNA NAcore, but suppressed hormone Together, these results show regulate neurobiology, additional factors may be required restore levels.

Язык: Английский

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Clinical and Preclinical Evidence for Gut Microbiome Mechanisms in Substance Use Disorders

Biological Psychiatry, Год журнала: 2023, Номер 95(4), С. 329 - 338

Опубликована: Авг. 10, 2023

Язык: Английский

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Mifepristone decreases nicotine intake in dependent and non-dependent adult rats

Journal of Psychopharmacology, Год журнала: 2024, Номер 38(3), С. 280 - 296

Опубликована: Фев. 8, 2024

Background: Addiction to tobacco and nicotine products has adverse health effects afflicts more than a billion people worldwide. Therefore, there is an urgent need for new treatments reduce use. Glucocorticoid receptor blockade shows promise as novel treatment drug abuse stress-related disorders. Aim: These studies aim investigate whether glucocorticoid with mifepristone diminishes the reinforcing properties of in rats intermittent or daily long access nicotine. Methods: The self-administered 0.06 mg/kg/inf 6 h per day, either 4 weeks before mifepristone. Daily self-administration models regular smoking, while occasional smoking. To determine were dependent, they treated nicotinic acetylcholine antagonist mecamylamine, somatic signs recorded. Results: had higher level intake session those but only showed physical dependence. Furthermore, mecamylamine increased during first hour not access. Mifepristone decreased total Moreover, distance traveled rearing open field test operant responding food pellets. Conclusion: findings indicate that decreases this effect may be partially attributed sedative

Язык: Английский

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Transcriptional characterization of cocaine withdrawal versus extinction within nucleus accumbens in male rats

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Март 25, 2025

Neurobiological alterations seen in addiction amplify during abstinence and compromise relapse prevention. Cocaine use disorder (CUD) exemplifies this phenomenon which reward regions such as nucleus accumbens (NAc) undergo withdrawal-associated modifications. While genome-wide transcriptional changes NAc are linked to specific phases, these have not been examined a context- NAc-subregion-specific manner withdrawal vs. extinction. We used cocaine self-administration male rats combined with RNA-sequencing of NAc-core -shell transcriptionally profile the home-cage, previous drug context, or after As expected, home-cage maintained seeking, whereas extinction reduced it. By contrast, involving context only increased seeking. Bioinformatic analyses revealed gene expression patterns networks associated states. Comparing datasets CUD patients highlighted conserved transcriptomic signatures experiencing context. Together, work reveals fundamental mechanisms that can be targeted attenuate relapse. A hallmark is propensity for following abstinence. Here, authors different rodent modalities relevant disorders humans.

Язык: Английский

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Gut microbiome depletion modulates cocaine-induced behavioral and transcriptional responses in female mice

Journal of Neuroimmunology, Год журнала: 2025, Номер unknown, С. 578609 - 578609

Опубликована: Апрель 1, 2025

Язык: Английский

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Translin deletion impairs cocaine-induced locomotor sensitization and RGS8 expression in the nucleus accumbens

Acta Pharmacologica Sinica, Год журнала: 2025, Номер unknown

Опубликована: Май 12, 2025

Язык: Английский

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The Bidirectional Interplay Between Substances of Abuse and Gut Microbiome Homeostasis

Life, Год журнала: 2025, Номер 15(6), С. 834 - 834

Опубликована: Май 22, 2025

Specific gut microorganisms and their metabolic by-products have been identified as key regulators of host physiology, contributing to the modulation immune system, inflammatory processes, brain function, behavior, which highlights microbiome a potential modulator neurobiological mechanisms involved in substance use disorders. This narrative review provides an updated overview how drugs abuse influence composition dynamics human bacterial dysbiosis may be factor disorders by modulating communication between brain. Thus, examining commonly abused substances such alcohol, psychostimulants, opioids, cannabinoids, nicotine, this aimed deepen understanding bidirectional relationship use. There is evidence indicating that alterations addiction through changes gut-brain signaling. Furthermore, its metabolites not only result from disorders, but could also modulate behavioral responses abuse. Although exact modulates are fully understood, microbial products short-chain fatty acids, tryptophan metabolites, bile neurotransmitters suggested play role process influencing blood–brain barrier permeability, activation, neural signaling, gene expression. Therefore, manipulating or represent promising approach for enhancing disorder treatments, identifying individuals at increased risk pathological drug use, elucidating substance-related behaviors.

Язык: Английский

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Estrous cycle and hormone regulation of stress-induced reinstatement of reward seeking in female mice

Addiction Neuroscience, Год журнала: 2022, Номер 4, С. 100035 - 100035

Опубликована: Сен. 9, 2022

Язык: Английский

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