Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Апрель 6, 2023
Abstract
Plasticity
is
the
ability
to
modify
brain
and
behavior
allows
transition
from
psychopathology
mental
wellbeing.
High
plasticity
has
been
associated
high
susceptibility
contextual
factors,
e.g.,
living
conditions,
which
ultimately
drive
outcome.
Here,
we
exploited
network
analysis
show
that
–
i.e.,
depression
score
can
be
assessed
by
measuring
symptom
connectivity:
weaker
connectivity,
higher
plasticity,
resulting
in
a
greater
modification
mood
symptoms.
We
analyzed
STAR*D
dataset
proved
connectivity
strength
at
baseline
responder
compared
non-responder
patients.
Moreover,
was
inversely
correlated
with
improvement
(Pearson's
r=-0.87)
change
according
context
r=-0.77).
This
operationalization
of
provides
mathematical
tool
investigate
predict
resilience,
vulnerability
recovery,
develop
novel
approaches
for
prevention
treatment
depression.
Neuroscience Applied,
Год журнала:
2024,
Номер
3, С. 104052 - 104052
Опубликована: Янв. 1, 2024
The
complex
dyadic
interaction
of
stress
and
resilience
has
received
growing
attention
as
a
promising
avenue
for
informing
new
diagnostic
prognostic
models
human
health.
In
this
review,
we
present
selection
some
the
most
relevant
data
on
translational
biomarkers
in
field
mental
Several
critical
aspects
concerning
preclinical
clinical
model
development
are
addressed.
distance
between
disease
widened
with
time
across
all
fields
medicine,
psychiatry
presenting
additional
hurdles
represented
by
inherent
heterogeneity
studied
phenotypes.
Capitalizing
technological
advances
developing
consolidating
sound
theories
stress-resilience
represents
avenue,
possibly
endowed
greater
ecological
validity
compared
to
sole
socio-psychological
assessment.
Instrumental
advancing
will
be
an
increased
level
integration
researchers'
efforts
biomarkers,
aiming
elucidate
better
interindividual
impact
exposure
individuals'
health
behavior.
NeuroImage,
Год журнала:
2024,
Номер
301, С. 120883 - 120883
Опубликована: Окт. 9, 2024
Methamphetamine
(MA)
use
disorder
is
a
chronic
neurotoxic
brain
disease
characterized
by
high
risk
of
relapse
driven
intense
cravings.
However,
the
neurobiological
signatures
cravings
remain
unclear,
limiting
effectiveness
various
treatment
methods.
Diffusion
MRI
(dMRI)
scans
from
62
MA
users
and
57
healthy
controls
(HC)
were
used
in
this
study.
The
longitudinally
followed
up
during
their
period
long-term
abstinence
(duration
abstinence:
347.52±99.25
days).
We
systematically
quantified
control
ability
each
region
for
craving-associated
state
transitions
using
network
theory
causal
perspective.
Craving-associated
structural
alterations
(CSA)
investigated
through
multivariate
group
comparisons
biological
relevance
analysis.
neural
mechanisms
underlying
CSA
elucidated
transcriptomic
neurochemical
analyses.
observed
that
abstinence-induced
significantly
influenced
transition
energy
involved
cognitive
response
to
external
information,
which
correlated
with
changes
craving
scores
(r
∼
0.35,
P
<0.01).
Our
analysis
further
supported
crucial
role
prefrontal
cortex
(PFC)
mechanisms.
Notably,
while
PFC
central
craving,
CSAs
distributed
widely
across
multiple
regions
(PFDR<0.05),
strong
somatomotor
(PFDR<0.05)
moderate
high-level
association
networks
(PFDR<0.05).
Additionally,
transcriptomic,
chemical
compounds,
cell-type
analyses,
molecular
imaging
collectively
highlight
influence
neuro-immune
communication
on
human
modulation.
results
offer
an
integrative,
multi-scale
perspective
unraveling
underpinnings
suggest
signaling
may
be
promising
target
future
addiction
therapeutics.
Heliyon,
Год журнала:
2023,
Номер
9(5), С. e15864 - e15864
Опубликована: Май 1, 2023
ObjectivesBipolar
and
unipolar
depressions
have
a
similar
clinical
picture,
but
different
neurological
psychological
mechanisms.
These
misleading
similarities
can
lead
to
overdiagnosis
increased
suicide
risk.
Recent
studies
show
that
gait
is
sensitive
objective
marker
for
distinguishing
the
type
of
depression.
The
present
study
aims
compare
psychomotor
reactivity
disorders
activity
in
bipolar
depression.MethodsA
total
636
people
aged
40.7
±
11.2
years
are
studied
with
an
ultrasound
cranio-corpo-graph.
They
divided
into
three
groups
-
patients
depression,
depression
healthy
controls.
Each
person
performs
tasks
classic
Unterberger
task,
simplified
version
open
eyes
complex
additional
cognitive
task.ResultsWe
find
significant
differences
between
groups.
Bipolar
more
inhibited
skills
than
they
both
norms.
variant
equilibriometric
task
most
one
precise
activity.ConclusionBoth
could
be
markers
psychiatric
conditions.
application
cranio-corpo-graph
possible
development
devices
new
diagnostic
therapeutic
approaches,
including
early
detection
prediction
Science,
Год журнала:
2024,
Номер
386(6728), С. 1356 - 1357
Опубликована: Дек. 19, 2024
Article
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data
available.05010022
Dec
202429
202405
Jan
202512
20251400TotalFirst
30
DaysTotal
number
of
downloads
for
the
first
days
after
content
publication
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Апрель 6, 2023
Abstract
Plasticity
is
the
ability
to
modify
brain
and
behavior
allows
transition
from
psychopathology
mental
wellbeing.
High
plasticity
has
been
associated
high
susceptibility
contextual
factors,
e.g.,
living
conditions,
which
ultimately
drive
outcome.
Here,
we
exploited
network
analysis
show
that
–
i.e.,
depression
score
can
be
assessed
by
measuring
symptom
connectivity:
weaker
connectivity,
higher
plasticity,
resulting
in
a
greater
modification
mood
symptoms.
We
analyzed
STAR*D
dataset
proved
connectivity
strength
at
baseline
responder
compared
non-responder
patients.
Moreover,
was
inversely
correlated
with
improvement
(Pearson's
r=-0.87)
change
according
context
r=-0.77).
This
operationalization
of
provides
mathematical
tool
investigate
predict
resilience,
vulnerability
recovery,
develop
novel
approaches
for
prevention
treatment
depression.
