International Clinical Psychopharmacology, Год журнала: 2023, Номер 39(2), С. 47 - 50
Опубликована: Дек. 21, 2023
Department of Medicine and Surgery, Kore University Enna, Italy Received 13 December 2023 Accepted 2023. Correspondence to Alessandro Serretti, MD, Piazza dell'Università, Enna 94100, Italy, e-mail: [email protected]
Язык: Английский
Diabetes Obesity and Metabolism, Год журнала: 2024, Номер 26(8), С. 3031 - 3044
Опубликована: Май 27, 2024
Abstract Depression is a mood disorder that may increase risk for the development of insulin resistance (IR) and type 2 diabetes (T2D), vice versa. However, mechanistic pathway linking depression T2D not fully elucidated. The aim this narrative review, therefore, was to discuss possible link between T2D. coexistence twice as great compared occurrence either condition independently. Hyperglycaemia dyslipidaemia promote incidence by enhancing inflammation reducing brain serotonin (5‐hydroxytryptamine [5HT]). Dysregulation signalling in impairs 5HT signalling, leading depression. Furthermore, associated with hyperglycaemia poor glycaemic control. Psychological stress In conclusion, could be potential factor through induction inflammatory reactions oxidative affect neurotransmission. addition, chronic induce dysregulation hypothalamic–pituitary–adrenal axis circulating cortisol levels, which triggers IR
Язык: Английский
Процитировано
17
Translational Psychiatry, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 24, 2025
This state-of-the-art review explores the relationship between depression and diabetes, highlighting two-way influences that make treatment challenging worsen outcomes of both conditions. Depression diabetes often co-occur share genetic, lifestyle, psychosocial risk factors. Lifestyle elements such as diet, physical activity, sleep patterns play a role on development management conditions, need for integrated strategies. The evidence suggests traditional strategies focusing either condition in isolation fall short addressing intertwined nature depression. Instead, care models encompassing psychological support medical are recommended to improve efficacy patient adherence. Such require collaboration across multiple healthcare disciplines, including endocrinology, psychiatry, primary care, offer holistic approach care. also identifies significant patient-related barriers effective management, stigma, resistance, health literacy, which be addressed through patient-centered education systems. Future directions research include longitudinal studies diverse populations further elucidate causal relationships exploration novel therapeutic targets, well effectiveness aimed at preventing onset one individuals diagnosed with other.
Язык: Английский
Процитировано
2
Current Opinion in Psychiatry, Год журнала: 2023, Номер 37(1), С. 23 - 28
Опубликована: Ноя. 9, 2023
Purpose of review The circular interactions between type 2 diabetes (TMD2) and major depressive disorder (MDD) are well documented but the understanding their mechanisms has only recently gained more clarity. Latest research indicates, that association TMD2 MDD is largely mediated by insulin resistance (IR). Recent findings A metabolic subtype can be distinguished from other subpopulations, characterized predominantly atypical clinical presentation, IR different responsiveness to antidepressant interventions. a predictor nonresponse some antidepressants. seems state-marker or subclinical depression relationship varies sexes ethnicities. Insulin direct impact on monoaminergic systems known underlie symptoms: serotoninergic dopaminergic, which dysregulated in subjects. Several trials assessed efficacy insulin-sensitizing drugs with mixed results for metformin consistent evidence pioglitazone lifestyle intervention/physical activity. Summary Recently published data suggest significant role pathophysiology treatment response MDD. Further integration existing into practice needed.
Язык: Английский
Процитировано
21
Frontiers in Endocrinology, Год журнала: 2024, Номер 14
Опубликована: Янв. 3, 2024
Background Diabetic retinopathy (DR) is the most frequent complication of type 2 diabetes and remains leading cause preventable blindness. Current clinical decisions regarding administration antidiabetic drugs do not sufficiently incorporate risk DR due to inconclusive evidence from preceding meta-analyses. This umbrella review aimed systematically evaluate effects on in people with diabetes. Methods A systematic literature search was undertaken Medline, Embase, Cochrane Library (from inception till 17th May 2022) without language restrictions identify reviews meta-analyses randomized controlled trials or longitudinal studies that examined association between Two authors independently extracted data assessed quality included using AMSTAR-2 (A MeaSurement Tool Assess Systematic Reviews) checklist, assessment performed GRADE (Grading recommendations, Assessment, Development Evaluation). Random-effects models were applied calculate relative (RR) odds ratios (OR) 95% confidence intervals (CI). study registered PROSPERO (CRD42022332052). Results With trial 11 meta-analyses, we found use glucagon-like peptide-1 receptor agonists (GLP-1 RA), sodium-glucose cotransporter-2 inhibitors (SGLT-2i), dipeptidyl peptidase-4 (DPP-4i) statistically associated DR, compared either placebo (RR: GLP-1 RA, 0.98, 0.89-1.08; SGLT-2i, 1.00, CI 0.79-1.27; DPP-4i, 1.17, 0.99-1.39) other drugs. Compared drugs, meglitinides (0.34, 0.01-8.25), SGLT-2i (0.73, 0.10-5.16), thiazolidinediones (0.92, 0.67-1.26), metformin (1.15, 0.81-1.63), sulphonylureas (1.24, 0.93-1.65), acarbose (4.21, 0.44-40.43) DR. only, insulin have a higher than (OR: 2.47, CI: 2.04-2.99). Conclusion Our results indicate are generally safe prescribe among Further robust large-scale investigating insulin, meglitinides, warranted. registration https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=332052 , identifier CRD42022332052.
Язык: Английский
Процитировано
9
Biochemical Pharmacology, Год журнала: 2024, Номер unknown, С. 116554 - 116554
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
8
Translational Psychiatry, Год журнала: 2024, Номер 14(1)
Опубликована: Дек. 27, 2024
The high comorbidity of major depressive disorder (MDD) with other diseases has been well-documented. However, the pairwise causal connections for MDD comorbid networks are poorly characterized. We performed Phenome-wide Mendelian randomization (MR) analyses to explore bidirectional associations between (N = 807,553) and 877 common from FinnGen datasets 377,277). inverse variance weighting method was primary technique, methods (weighted median MR-Egger) were used sensitivity analyses. Our MR showed that genetic liability is causally associated risks 324 disease phenotypes (average b: 0.339), including 46 psychiatric behavioral disorders 0.618), 18 neurological 0.348), 44 respiratory 0.345), 40 digestive 0.281), circulatory 0.237), 37 genitourinary 0.271), 66 musculoskeletal connective 0.326), 22 endocrine 0.302), others. In a reverse analysis, total 51 components predisposing various risk 0.086), 5 infectious 0.056), 11 0.106), 14 oncological 0.108), 0.114). Bidirectional identified 15 diseases. For most analyses, little evidence heterogeneity pleiotropy detected. findings confirmed extensive significant role predisposition in contributing human phenotypes, which more pronounced than those seen analysis influences on MDD.
Язык: Английский
Процитировано
8
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Март 8, 2024
Abstract The co-occurrence of insulin resistance (IR)-related metabolic conditions with neuropsychiatric disorders is a complex public health challenge. Evidence the genetic links between these phenotypes emerging, but little currently known about genomic regions and biological functions that are involved. To address this, we performed Local Analysis [co]Variant Association (LAVA) using large-scale (N=9,725-933,970) genome-wide association studies (GWASs) results for three IR-related (type 2 diabetes mellitus, obesity, syndrome) nine disorders. Subsequently, positional expression quantitative trait locus (eQTL)-based gene mapping downstream functional analyses were on significant loci. Patterns negative positive local correlations (|r g |=0.21-1, p FDR <0.05) identified at 109 unique across all phenotype pairs. emerged even in absence global Alzheimer’s disease, bipolar disorder, Tourette’s syndrome. Genes mapped to correlated showed enrichment pathways integral immune-inflammatory function, vesicle trafficking, signalling, oxygen transport, lipid metabolism. Colocalisation further prioritised 10 genetically likely harbouring shared causal variants, displaying high deleterious or regulatory potential. These variants found within close proximity genes, such as SLC39A8 HLA-DRB1 , can be targeted by supplements already drugs, including omega-3/6 fatty acids, immunomodulatory, antihypertensive, cholesterol-lowering drugs. Overall, our findings underscore landscape IR-neuropsychiatric multimorbidity, advocating an integrated disease model offering novel insights research treatment strategies this domain. Highlights correlations. Both Enrichment immune, signalling pathways, among others. Pinpointed regions. Identified therapeutic targets, e.g., HLA-DRB1, drug repurposing.
Язык: Английский
Процитировано
7
Nutrients, Год журнала: 2025, Номер 17(4), С. 613 - 613
Опубликована: Фев. 8, 2025
Objectives: Comorbid diabetes is an important factor in the treatment of major psychiatric disorders. However, a substantial proportion diabetic patients remain undetected by routine indices such as blood glucose and HbA1c. This study tried to estimate rates unidentified or prediabetic using 75 g oral tolerance test (OGTT). Methods: Participants were 25 with depressive disorder (MDD), 28 bipolar (BP), 26 schizophrenia, psychiatrically normal controls. They all Japanese, showed non-diabetic levels (<126 mg/dL) HbA1c (<6.0%). Results: Relatively high mellites (DM)-type abnormality (32% MDD, 21.4% BP 42.3% schizophrenia v. 10.7% controls). The difference between control groups was statistically significant (p = 0.008). When abnormal metabolism defined state (either glycemia, impaired fast glycemia tolerance) DM type OGTT, it more frequently seen than controls (64% 46.4% 46.2% 35.7% Individuals higher values compared those < 0.001) 0.021) states. Conclusions: results suggest that relatively proportions for metabolism, indicating importance OGTT even if
Язык: Английский
Процитировано
1
JAMA Pediatrics, Год журнала: 2024, Номер unknown
Опубликована: Окт. 14, 2024
Importance Glucagon-like peptide 1 receptor agonists (GLP1R) are increasingly being used for the treatment of obesity in adolescents. It is currently unknown whether GLP1R associated with suicidal ideation or attempts this population. Objective To investigate association between initiation and adolescents obesity. Design, Setting, Participants Retrospective propensity score–matched cohort study using electronic health records from TriNetX global federated network December 2019 June 2024. The analysis included data 120 care organizations, mainly USA. were aged 12 to 18 years a diagnosis evidence an antiobesity prescription lifestyle intervention without within following year. Cohorts balanced baseline demographic characteristics, psychiatric medications comorbidities, diagnoses socioeconomic status access score matching. Exposure Initial (study cohort) (control cohort). Main Outcomes Measures Incidence based on International Statistical Classification Diseases Related Health Problems, Tenth Revision codes recorded patient during months follow-up. Diagnoses upper respiratory tract infections (URTI) as negative control outcomes, gastrointestinal symptoms (GI) positive outcomes. Results A total 4052 concomitant identified 50 112 cohort. Propensity matching resulted 3456 participants each Prescription was 33% reduced risk over follow-up (1.45% vs 2.26%; hazard ratio [HR], 0.67; 95% CI, 0.47-0.95; P = .02) higher rate GI (6.9% 5.4%; HR, 1.41; 1.12-1.78; .003) but no difference rates URTI diagnoses. Conclusions Relevance In study, prescribed had lower incidence compared matched patients not who treated intervention. These results suggest favorable safety profile detected reduction HRs among suggests potential avenues future research.
Язык: Английский
Процитировано
5
Frontiers in Psychiatry, Год журнала: 2023, Номер 14
Опубликована: Июль 28, 2023
Triglyceride glucose (TyG) index has been suggested as an alternative indicator of insulin resistance (IR); however, the association between TyG and suicide attempts (SA) in major depressive disorder (MDD) is unclear. The aim this study was to investigate relationship SA Chinese patients with first-episode drug-naïve (FEDN) MDD.This cross-sectional enrolled 1,718 FEDN MDD aged 34.9 ± 12.4 years from First Hospital Shanxi Medical University (Taiyuan, Province, China) September 2016 December 2018. Multivariable binary logistic regression analysis used estimate risk SA. A two-piecewise linear model threshold effects if non-linearity associations existed. Interaction stratified analyses were performed based on sex, education, marital status, comorbid anxiety, psychotic symptoms.Multivariable revealed that positively associated after adjusting for confounders (OR = 1.35, 95% CI: 1.04-1.75, p 0.03). Smoothing plots also showed a nonlinear SA, inflection point being 9.29. On right point, positive detected 3.47, 1.81 6.66, < 0.001), while no significant observed left side 1.14, 0.79 1.66, 0.476).The non-linear exhibited effect MDD. When greater than 9.29, they correlation.
Язык: Английский
Процитировано
10