Consciousness and Cognition, Год журнала: 2024, Номер 127, С. 103803 - 103803
Опубликована: Дек. 28, 2024
Язык: Английский
Antioxidants, Год журнала: 2024, Номер 13(4), С. 393 - 393
Опубликована: Март 25, 2024
The aging of the global population has increased prevalence neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic quercetin, demonstrates potential for brain health. Limited research been conducted on therapeutic applications BM in This systematic review aims to project BM’s beneficial role disorders. anti-apoptotic antioxidant actions can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, increase neuroprotection. included twenty-two clinical trials demonstrated that reduce Nuclear Factor-κB phosphorylation, emotional cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, psychiatric problems. Moreover, levels pro-inflammatory biomarkers oxidative stress. Here, we highlight provides notable benefits serve a complementary approach care patients conditions associated adds growing interest natural products their by improving our understanding mechanisms underlying function neurodegeneration informing development new strategies diseases.
Язык: Английский
Процитировано
39
Translational Psychiatry, Год журнала: 2024, Номер 14(1)
Опубликована: Янв. 15, 2024
Abstract Fear-induced bradycardia, a transient heartbeat deceleration following exposure to threat, is physiological index observable in humans, especially fear conditioning experiments. While gaining interest recent years, it still currently underemployed neuroscientific research compared more popular indices. Besides its use research, could also constitute valuable resource clinical psychiatry setting, as many disorders are characterized by altered heart rate responses. However, differences fear-induced bradycardia may be subtended genetic interindividual differences, thus suggesting precaution when recommending the setting. Here, we discussed first endeavors that aimed at clarifying underpinnings of variations, which suggest individual have role defining characteristics Given this, translating measurements setting must implemented with caution. Future this field will aim identifying these even further, allowing for precise interventions.
Язык: Английский
Процитировано
27
Biomedicines, Год журнала: 2024, Номер 12(3), С. 574 - 574
Опубликована: Март 5, 2024
Neurodegeneration poses a significant challenge for the fields of neuroscience and medicine, as it is underlying cause development advancement numerous neurodegenerative psychiatric disorders [...]
Язык: Английский
Процитировано
25
Advances in Clinical and Experimental Medicine, Год журнала: 2024, Номер 33(4), С. 321 - 326
Опубликована: Март 21, 2024
A harmonic brain-body communication is fundamental to individual wellbeing and the basis of human cognition behavior.In last 2 decades, interaction between brain body functioning has become a central area study for neurologists neuroscientists in clinical non-clinical contexts.Indeed, axis dysfunctions occur many psychiatric, neurological neurodegenerative diseases.This editorial will focus on recent advances future therapeutic perspectives studying interactions health diseases.
Язык: Английский
Процитировано
22
Biomedicines, Год журнала: 2024, Номер 12(3), С. 613 - 613
Опубликована: Март 8, 2024
Neuroscience, neurology, and psychiatry are rapidly evolving fields that aim to understand the complex mechanisms underlying brain function dysfunction, as well develop effective interventions for various neurological psychiatric disorders [...]
Язык: Английский
Процитировано
19
Biomedicines, Год журнала: 2024, Номер 12(5), С. 1083 - 1083
Опубликована: Май 13, 2024
Welcome to
Язык: Английский
Процитировано
17
Опубликована: Март 5, 2024
Delve into the dynamic realms of neuroscience, neurology, and psychiatry with this groundbreaking editorial, unveiling intricate mechanisms brain function dysfunction. Explore latest advancements in molecular biology, genetics, epigenetics, pharmacology, neuroimaging that are revolutionizing our understanding neurological psychiatric disorders. Uncover challenges gaps translating cutting-edge research practical clinical applications, aiming to enhance lives patients their families. Discover pivotal role neuroplasticity reshaping brain's adaptability throughout life, alongside promising potential non-invasive stimulation techniques like transcranial magnetic direct current stimulation. Embark on a journey innovation collaboration as researchers clinicians strive bridge gap between bench bedside, offering hope for improved diagnosis, prevention, treatment complex conditions. Join us exploration transformative ideas novel interventions hold key brighter future individuals society.
Язык: Английский
Процитировано
16
Frontiers in Bioscience-Landmark, Год журнала: 2025, Номер 30(1)
Опубликована: Янв. 20, 2025
Backgrounds: Memory and emotion are especially vulnerable to psychiatric disorders such as post-traumatic stress disorder (PTSD), which is linked disruptions in serotonin (5-HT) metabolism. Over 90% of the 5-HT precursor tryptophan (Trp) metabolized via Trp-kynurenine (KYN) metabolic pathway, generates a variety bioactive molecules. Dysregulation KYN metabolism, particularly low levels kynurenic acid (KYNA), appears be neuropsychiatric disorders. The majority KYNA produced by aadat (kat2) gene-encoded mitochondrial kynurenine aminotransferase (KAT) isotype 2. Little known about consequences deleting enzyme gene. Methods: In CRISPR/Cas9-induced knockout (kat2-/-) mice, we examined effects on emotion, memory, motor function, Trp its metabolite levels, activities plasma urine 8-week-old males compared wild-type mice. Results: Transgenic mice showed more depressive-like behaviors forced swim test, but not tail suspension, anxiety, or memory tests. They also had fewer center field corner entries, shorter walking distances, jumping counts open test. Plasma generally consistent with those urine: antioxidant KYNs, 5-hydroxyindoleacetic acid, indole-3-acetic were lower; KATs, kynureninase, monoamine oxidase/aldehyde dehydrogenase lower, 3-monooxygenase was higher; oxidative excitotoxicity indices higher. displayed depression-like behavior learned helplessness model, emotional indifference, deficits, coupled decrease KYNA, shift metabolism toward KYN-3-hydroxykynurenine partial gut microbial Trp-indole pathway metabolite. Conclusions: This first evidence that gene induces uniquely experiences despair, appear associated excitatory neurotoxic stresses. may lead development double-hit preclinical model despair-based depression, better understanding these complex conditions, effective therapeutic strategies elucidating relationship between PTSD pathogenesis.
Язык: Английский
Процитировано
2
Cells, Год журнала: 2024, Номер 13(13), С. 1098 - 1098
Опубликована: Июнь 25, 2024
Migraine is a debilitating neurological disorder characterized by recurring episodes of throbbing headaches that are frequently accompanied sensory disturbances, nausea, and sensitivity to light sound [...]
Язык: Английский
Процитировано
13
Опубликована: Апрель 12, 2024
Alzheimer's disease (AD) is a stealthy and progressive neurological disorder that leading cause of dementia in the global elderly population, imposing significant burden on both society. Currently, condition treated with medications alleviate symptoms. Nonetheless, these drugs may not consistently produce desired results can serious side effects. Hence, there vigorous pursuit alternative options to enhance quality life for patients. Ginkgo biloba (GB), an herb historical use traditional medicine, contains bioactive compounds such as terpenoids (Ginkgolides A, B, C), polyphenols, organic acids, flavonoids (quercetin, kaempferol, isorhamnetin). These are associated anti-inflammatory, antioxidant, neuroprotective properties, making them valuable cognitive health. A systematic search across three databases using specific keywords GB AD yielded 1702 documents, selection 15 clinical trials synthesis. In eleven studies, extract/EGb 761® was shown improve function, neuropsychiatric symptoms, functional abilities types. four however, were no differences between GB-treated placebo groups. Significant improvements observed scores obtained from Mini-Mental State Examination (MMSE), Short Cognitive Performance Test (SKT), Neuropsychiatric Inventory (NPI). While majority synthesized show has promising potential conditions, more research needed determine optimal dosages, effective delivery methods, appropriate pharmaceutical formulations. Furthermore, thorough assessment adverse effects, exploration long-term implications, investigation into drug interactions critical aspects must be carefully evaluated future studies.
Язык: Английский
Процитировано
12