Systematical Comparison Reveals Distinct Brain Transcriptomic Characteristics in Depression Models Induced by Gut Microbiota Dysbiosis and Chronic Stress
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 17, 2025
Язык: Английский
Temporomandibular disorders and mental health: shared etiologies and treatment approaches
Jiamin Wan,
Jiu Lin,
Tingfeng Zha
и другие.
The Journal of Headache and Pain,
Год журнала:
2025,
Номер
26(1)
Опубликована: Март 12, 2025
The
biopsychosocial
model
suggests
that
temporomandibular
disorders
(TMDs)
often
coexist
with
mental
health
disorders,
particularly
depression
and
anxiety,
affecting
a
significant
portion
of
the
global
population.
interplay
between
TMDs
contributes
to
complex
comorbidity,
perpetuating
cycle
mutual
influence
reinforcement.
This
review
investigates
neurobiological
mechanisms
epidemiological
evidence
supporting
shared
etiology
exploring
potential
vulnerabilities
bidirectional
causal
relationships.
Shared
may
stem
from
genetic
epigenetic
predispositions,
psychosocial
factors,
behavioral
aspects.
Inflammatory
cytokines,
neurotransmitters,
neurotrophins,
neuropeptides
play
pivotal
roles
in
both
peripheral
central
sensitization
as
well
neuroinflammation.
Brain
imaging
studies
suggest
exhibit
overlapping
brain
regions
indicative
reward
processing
deficits
anomalies
within
triple
network
model.
Future
research
efforts
are
crucial
for
developing
comprehensive
understanding
underlying
confirming
reciprocal
effects
disorders.
provides
valuable
insights
oral
healthcare
professionals,
stressing
importance
optimizing
treatment
strategies
individuals
dealing
concurrent
issues
through
personalized,
holistic,
multidisciplinary
approach.
Язык: Английский
Altered neurovascular coupling in depression with childhood maltreatment
Progress in Neuro-Psychopharmacology and Biological Psychiatry,
Год журнала:
2025,
Номер
unknown, С. 111348 - 111348
Опубликована: Апрель 1, 2025
Язык: Английский
Seed-based resting-state connectivity as a neurosignature in fibromyalgia and depression: a narrative systematic review
Frontiers in Human Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Апрель 28, 2025
Background
Major
depressive
disorder
(MDD)
often
co-occur
with
fibromyalgia
(FM),
and
both
conditions
have
been
associated
impaired
resting
state
functional
connectivity
(rs-FC).
The
present
systematic
review
aims
to
summarize
the
evidence
on
rs-FC
in
individuals
MDD
FM
compared
healthy
controls
explore
overlapping
patterns
their
relationships
clinical
symptoms.
Methods
A
search
of
EMBASE,
PubMed,
Scopus
ScienceDirect
databases
was
conducted
according
PRISMA
guidelines.
Studies
were
included
that
addressed
using
seed-based
analysis
patients
HC.
Methodological
quality
risk
bias
assessed
a
13-point
checklist
adapted
from
previous
neuroimaging
meta-analyzes.
Results
total
33
articles
(17
16
FM).
sample
comprised
1,877
individuals,
including
947
930
controls,
mean
age
39.83
years.
seeds
categorized
into
six
neural
networks.
Shared
disruptions
across
studies
identified
key
circuits,
decreased
between
insula
anterior
cingulate
cortex
(ACC),
middle
frontal
gyrus
(MFG),
superior
(SFG),
putamen.
Increased
FC
observed
dorsolateral
prefrontal
(DLPFC)
ACC,
as
well
thalamus
precuneus.
Decreased
insula-ACC
correlated
greater
pain
intensity
catastrophizing
more
severe
symptoms
MDD.
Unique
also
observed:
FM-specific
changes
involved
periaqueductal
gray,
hypothalamus,
thalamus,
indicating
modulation
emotional
processing.
In
contrast,
MDD-specific
primarily
reward,
salience,
default
mode
networks,
reflecting
regulation.
showed
considerable
heterogeneity
selection
study
designs,
which
limits
feasibility
meta-analyses
underlines
need
for
standardized
methods.
Findings
This
provides
information
about
distinct
mechanisms
MDD,
suggesting
potentially
presence
potential
neurosignature
reflects
shared
emotion
regulation
networks
while
highlighting
unique
pathways
underlying
respective
pathophysiology.
Язык: Английский
Integrated analysis of transcriptional changes in major depressive disorder: Insights from blood and anterior cingulate cortex
Heliyon,
Год журнала:
2024,
Номер
10(8), С. e28960 - e28960
Опубликована: Апрель 1, 2024
Major
depressive
disorder
(MDD)
was
involved
in
widely
transcriptional
changes
central
and
peripheral
tissues.
While,
previous
studies
focused
on
single
tissues,
making
it
difficult
to
represent
systemic
molecular
throughout
the
body.
Thus,
there
is
an
urgent
need
explore
biomarkers
with
intrinsic
correlation.
Язык: Английский
Role of Prefrontal Cortex Circuitry in Maintaining Social Homeostasis
Biological Psychiatry,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 1, 2024
Язык: Английский
Disruptions in segregation mechanisms in fMRI-based brain functional network predict the major depressive disorder condition
Chaos Solitons & Fractals,
Год журнала:
2024,
Номер
188, С. 115566 - 115566
Опубликована: Окт. 1, 2024
Язык: Английский
Giant Fusiform Cells of the Brain: Discovery, Identification, and Probable Functions
Cytology and Genetics,
Год журнала:
2024,
Номер
58(5), С. 411 - 427
Опубликована: Сен. 20, 2024
Язык: Английский
Modulation effects of repetitive transcranial magnetic stimulation on target and indirect target nodes in patients with major depressive disorder
Jiayu Pan,
Keming Ren,
Jiashu Yao
и другие.
Journal of Psychiatric Research,
Год журнала:
2024,
Номер
180, С. 147 - 153
Опубликована: Окт. 12, 2024
Язык: Английский
The Habenula in Mood Disorders: A Scoping Review of Human Studies
Опубликована: Апрель 10, 2024
In
animal
models,
the
habenula
has
been
identified
as
a
key
structure
involved
in
depression.
Thanks
to
recent
technological
advancements,
burgeoning
body
of
work
also
investigated
context
human
mood
disorders.
This
scoping
review
aims
synthesize
findings
from
studies
that
pertain
and
its
relationship
with
The
was
conducted
according
PRISMA
guidelines.
literature
search
performed
PubMed
yielded
93
articles,
which
50
articles
were
included
review.
We
found
evidence
for
baseline
habenular
hyperactivity
depression
is
mixed.
As
resting-state
functional
connectivity
(RSFC)
studies,
they
mainly
inconsistent
across
studies.
Moreover,
we
no
indicating
disorders
are
linked
changes
volume
habenula.
order
enhance
replicability
findings,
given
small
size
habenula,
higher
image
resolution
larger
samples
recommended
future
Язык: Английский