Cholecystokinin neurotransmission in the central nervous system: Insights into its role in health and disease
BioFactors,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 22, 2024
Abstract
Cholecystokinin
(CCK)
plays
a
key
role
in
various
brain
functions,
including
both
health
and
disease
states.
Despite
the
extensive
research
conducted
on
CCK,
there
remain
several
important
questions
regarding
its
specific
brain.
As
result,
existing
body
of
literature
subject
is
complex
sometimes
conflicting.
The
primary
objective
this
review
article
to
provide
comprehensive
overview
recent
advancements
understanding
central
nervous
system
with
emphasis
elucidating
CCK's
mechanisms
for
neuroplasticity,
exploring
interactions
other
neurotransmitters,
discussing
significant
involvement
neurological
disorders.
Studies
demonstrate
that
CCK
mediates
inhibitory
long‐term
potentiation
(iLTP)
excitatory
(eLTP)
Activation
GPR173
receptor
could
facilitate
iLTP,
while
B
(CCKBR)
facilitates
eLTP.
receptors'
expression
different
neurons
regulates
activity,
neurotransmitter
release,
plasticity,
emphasizing
modulating
function.
Furthermore,
pivotal
emotional
states,
Alzheimer's
disease,
addiction,
schizophrenia,
epileptic
conditions.
Targeting
cell
types
circuits
holds
promise
as
therapeutic
strategy
alleviating
these
Язык: Английский
Basolateral amygdala parvalbumin and cholecystokinin-expressing GABAergic neurons modulate depressive and anxiety-like behaviors
Translational Psychiatry,
Год журнала:
2024,
Номер
14(1)
Опубликована: Окт. 5, 2024
Язык: Английский
Understanding the neurobiological mechanisms of LPS‑induced memory impairment
Acta Neurobiologiae Experimentalis,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
In
recent
years,
growing
evidence
suggests
that
lipopolysaccharide
(LPS),
a
bacterial
endotoxin
found
in
the
outer
membrane
of
gram‑negative
bacteria,
can
influence
cognitive
functions,
particularly
memory
formation
and
retrieval.
However,
underlying
mechanisms
through
which
LPS
exerts
its
effects
on
remain
incompletely
understood.
This
review
used
various
electronic
databases,
including
PubMed,
Scopus,
Web
Science,
to
identify
relevant
studies
published
between
2000
2024.
Articles
were
selected
based
their
focus
LPS‑induced
impairments,
experimental
models,
molecular
pathways,
neurochemical
alterations.
administration
has
been
consistently
shown
disrupt
processes
both
animals
humans,
although
magnitude
duration
impairments
might
vary
depending
factors
such
as
dose,
timing,
context
exposure.
Several
potential
have
proposed
explain
deficits,
neuroinflammation,
alterations
synaptic
plasticity,
disruption
neurotransmitter
systems,
dysfunction
blood‑brain
barrier.
Moreover,
activate
immune
signaling
toll‑like
receptors,
interleukins,
microglia,
further
contribute
impairments.
Such
insights
may
pave
way
for
development
targeted
therapeutic
interventions
aimed
at
ameliorating
deficits
associated
with
conditions
involving
exposure,
infections,
sepsis,
neuroinflammatory
disorders.
Язык: Английский
The neuroprotective effects of cholecystokinin in the brain: antioxidant, anti-inflammatory, cognition, and synaptic plasticity
Reviews in the Neurosciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 20, 2025
Abstract
Cholecystokinin
(CCK)
is
a
major
neuropeptide
in
the
brain
that
functions
as
neurotransmitter,
hormone,
and
growth
factor.
The
peptide
its
receptors
are
widely
expressed
brain.
CCK
signaling
modulates
synaptic
plasticity
can
improve
or
impair
memory
formation,
depending
on
areas
studies
receptor
subtype
activated.
Studies
have
shown
series
of
animal
models
neurodegenerative
diseases
agonists
show
neuroprotective
effects
effectively
alleviate
oxidative
stress,
chronic
inflammation
central
nervous
system,
neuronal
plasticity,
prevent
loss,
cognitive
dysfunction
Alzheimer’s
disease
(AD)
model
mice
motor
activity
Parkinson’s
disease.
In
addition,
plays
important
roles
amygdala
to
regulate
anxiety
depressive
states.
Activation
interneurons
inhibition
excitatory
neurons
levels.
This
review
summarizes
formation
cholecystokinin
analogs
neurological
such
Alzheimer
disease,
amygdala.
Язык: Английский
CB1 Receptor Signaling: Linking Neuroplasticity, Neuronal Types, and Mental Health Outcomes
Neurochemistry International,
Год журнала:
2025,
Номер
unknown, С. 105938 - 105938
Опубликована: Фев. 1, 2025
Язык: Английский
Sleep links hippocampal propensity for epileptiform activity to its viscerosensory inputs
Frontiers in Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Март 13, 2025
The
development
of
a
seizure
relies
on
two
factors.
One
is
the
existence
an
overexcitable
neuronal
network
and
other
trigger
that
switches
normal
activity
into
paroxysmal
state.
While
mechanisms
local
overexcitation
have
been
focus
many
studies,
process
triggering
remains
poorly
understood.
We
suggest
that,
apart
from
known
exteroceptive
sources
reflex
epilepsy
such
as
visual,
auditory
or
olfactory
signals,
there
range
interoceptive
triggers,
which
are
relevant
for
in
Temporal
Lobe
Epilepsy
(TLE).
hypothesis
proposed
here
aims
to
explain
prevalence
epileptic
sleep
drowsiness
states
provide
detailed
mechanism
seizures
triggered
by
signals.
Язык: Английский
Unraveling the Role of Cholecystokinin in Epilepsy: Mechanistic Insight Into Neuroplasticity.
Neurochemistry International,
Год журнала:
2024,
Номер
180, С. 105870 - 105870
Опубликована: Сен. 28, 2024
Язык: Английский
Unraveling the Influence of Litter Size, Maternal Care, Exercise, and Aging on Neurobehavioral Plasticity and Dentate Gyrus Microglia Dynamics in Male Rats
Brain Sciences,
Год журнала:
2024,
Номер
14(5), С. 497 - 497
Опубликована: Май 15, 2024
This
study
explores
the
multifaceted
influence
of
litter
size,
maternal
care,
exercise,
and
aging
on
rats’
neurobehavioral
plasticity
dentate
gyrus
microglia
dynamics.
Body
weight
evolution
revealed
a
progressive
increase
until
maturity,
followed
by
decline
during
aging,
with
larger
litters
exhibiting
lower
weights
initially.
Notably,
exercised
rats
from
smaller
displayed
higher
body
mature
aged
stages.
The
volumes
showed
no
significant
differences
among
groups,
except
for
sedentary
litters,
which
exhibited
reduction.
Maternal
care
varied
significantly
based
large
dams
showing
frequencies
caregiving
behaviors.
Behavioral
assays
highlighted
detrimental
impact
lifestyle
reduced
care/large
spatial
memory,
mitigated
exercise
in
litters.
microglial
dynamics
layers
age-related
changes
modulated
size
exercise.
Exercise
interventions
microgliosis
associated
particularly
rats.
These
findings
underscore
complex
interplay
between
early-life
experiences,
dynamics,
outcomes
aging.
Язык: Английский
Impact of Masticatory Activity and Rehabilitation on Astrocyte Morphology Across the Molecular Layer of the Dentate Gyrus: Insights from the Outer, Medial, and Inner Sublayers and Their Relationship with Spatial Learning and Memory
Annals of Anatomy - Anatomischer Anzeiger,
Год журнала:
2024,
Номер
unknown, С. 152356 - 152356
Опубликована: Ноя. 1, 2024
The
dentate
gyrus
plays
a
crucial
role
in
learning
and
spatial
memory,
particularly
its
middle
third
molecular
layer,
which
receives
the
primary
afferent
input
via
medial
perforant
path.
Interestingly,
changes
masticatory
activity
are
described
to
affect
this
region
with
visible
astrogliosis,
release
of
pro-inflammatory
cytokines
oxidative
stress,
affecting
synaptic
physiology,
cognition.
This
study
aimed
investigate
impact
altered
on
memory
young
Swiss
albino
mice,
correlating
these
effects
morphological
astrocytes.
mice
were
divided
into
three
groups:
Hard
diet
pellets
(HD),
hard
diet/soft
(HD/SD,
reduced
activity),
HD/SD/HD
(rehabilitated).
Morris
water
maze
test
was
used
measure
escape
latency,
while
three-dimensional
microscopic
reconstruction
methods
provided
morphometric
data
Hierarchical
clustering
analysis
validated
existence
four
subtypes
decreasing
complexity
(AST1,
AST2,
AST3,
AST4),
outer,
middle,
inner
thirds
layer.
Changes
affected
number
distribution
astrocytes
excepting
AST3
Canonical
discriminant
function
indicated
that
variable
most
influencing
cluster
formation.
Correlation
tests
between
latency
for
each
animal
group
showed
significant
correlation
large
effect
size
60%
[Pearson's
R:
0.605,
p
<
0.001]
HD
third,
disrupted
by
activity.
morphotype
linear
functions
0.624,
disappeared
reduction
activity,
nor
restored
rehabilitation.
finding
not
observed
outer
layers,
supporting
contribution
memory.
Group
comparison
also
revealed
differentially
impacts
astrocyte
subpopulations
Data
validate
influence
suggest
association
tasks
female
mice.
Further
research
underlying
mechanisms
relationships
is
essential
identify
potential
therapeutic
targets
cognitive
disorders
develop
effective
interventions
preserve
function.
Язык: Английский