bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 22, 2024

The environment, especially social features, plays a key role in shaping the development of brain, notably during adolescence. To better understand variation brain-environment coupling and its associated outcomes, we identified ''envirotypes,'' or different patterns environment experience, Adolescent Brain Cognitive Development Study by hierarchically clustering subjects. Two focal clusters, which accounted for 89.3% all participants, differed significantly on eight out nine youth-report quality measures, representing almost perfect complements. We then applied tools from network neuroscience to show envirotypes are with whole brain functional connectivity. Differences were distributed across but prominent Default Somatomotor Hand systems these clusters. Finally, examined how change over suite outcomes. resulting dynamic along dimensions stability quality, outcomes diverged based stability. Specifically, stable, high envirotype was most easily distinguished improving envirotype, while unstable worst Altogether, our findings represent significant contributions both developmental neuroscience, emphasizing variability dynamicity consequences.

Язык: Английский