Impact of Physical Activity, Sedentary Behavior, and Basal Metabolic Rate on PTSD, Depression, and Emotional Instability DOI Creative Commons

Tianyi Lyu,

Haonan Qian,

Sung-Pil Chung

и другие.

Brain Sciences, Год журнала: 2024, Номер 14(11), С. 1071 - 1071

Опубликована: Окт. 27, 2024

Objective: This study aimed to investigate the potential associations between physical activity, sedentary behavior, and basal metabolic rate (BMR) with post-traumatic stress disorder (PTSD), major depressive (MDD), emotional instability (EI) using bidirectional Mendelian randomization (MR). Additionally, it sought identify key molecular mechanisms underlying through a comprehensive bioinformatic analysis. Methods: MR analyses utilizing genome-wide association (GWAS) data were conducted estimate effects of BMR on PTSD, MDD, EI. Sensitivity performed assess robustness findings. Concurrently, analysis was executed gene expression datasets (GSE53987 GSE21138) derived from emotionally unstable patients. encompassed differential differentially expressed genes (DEGs), followed by an functional enrichment uncover pathways associated Results: The revealed that increased activity may have protective effect against albeit inconsistent MDD Sedentary behavior demonstrated minimal or identified 114 DEGs EI, YWHAB, SRRM2, MST1, HDAC10, HSPA1A highlighted as significant genes. these unveiled potentially involved in pathology instability. Conclusions: Physical appears protect whereas its EI are less definitive. findings offer deeper understanding pinpointing specific serve therapeutic targets. Further research is warranted elucidate intricate interactions mechanisms.

Язык: Английский

Dreams and Nightmares in Early Pregnancy: A Comparative Study with a Control Group DOI Creative Commons
Serena Scarpelli, Marta Spinoni, Maurizio Gorgoni

и другие.

Nature and Science of Sleep, Год журнала: 2025, Номер Volume 17, С. 851 - 864

Опубликована: Май 1, 2025

This study investigated dream characteristics in women during the first trimester of pregnancy compared to a group non-pregnant women, aiming identify variables associated with observed differences. A sample 100 pregnant their was control age-matched women. Participants completed online questionnaires assess activity, sleep quality, depressive symptoms, and sociodemographic variables. Controlling for socio-demographic variables, statistical comparisons revealed that reported fewer nightmares showed less interest activity Ordinal logistic regression being group, greater attention dreams, presence higher frequency lucid dreaming were significant predictors more frequent nightmares. Moderation analysis no interaction between status attitude. Contrary expectations, first-trimester had than However, results are coherent finding parasomnia-like events decrease pregnancy. The rapid hormonal changes specific emotional features this stage gestation may explain lower as our group. Moreover, we confirmed crucial role attitude recalling nightmares, suggesting some stable, trait-like contribute nightmare experiences independently status. Our also confirmed, according Continuity hypothesis, symptoms Also, association be interpreted an attempt cope unpleasant emotions. Longitudinal studies needed examine how evolves across stages.

Язык: Английский

Процитировано

0

Exploring the role of dreams: insights from recent studies DOI
Serena Scarpelli, Valentina Alfonsi, Luigi De Gennaro

и другие.

Current Opinion in Pulmonary Medicine, Год журнала: 2024, Номер 30(6), С. 583 - 588

Опубликована: Авг. 8, 2024

Purpose of review Dreaming has only recently become a topic scientific research. This updates current findings on dream studies, emphasizing recent research the neural mechanisms dreaming. Additionally, it summarizes new evidence functional role dreams, including insights from studies dreams and nightmares during coronavirus disease 2019 (COVID-19) pandemic. Recent advances basis mental activity sleep have shifted towards dream-related phenomena, such as experiences in relation to parasomnias hypnagogic hallucinations. Although some are consistent with main models explaining recall (i.e., continuity hypothesis; activation hypothesis), results contrast parieto-occipital region experience. Moreover, – related COVID-19 pandemic underlined that could express emotion regulation processes well provide simulation reality prepare for future dangerous or social interactions. Summary Overall, we highlighted intricate interplay between brain regions dreaming suggest serve multiple functions, reflecting waking-life simulating adaptive responses threats. Understanding bases functions can valuable into human health, nevertheless, further is needed.

Язык: Английский

Процитировано

1

Impact of Physical Activity, Sedentary Behavior, and Basal Metabolic Rate on PTSD, Depression, and Emotional Instability DOI Creative Commons

Tianyi Lyu,

Haonan Qian,

Sung-Pil Chung

и другие.

Brain Sciences, Год журнала: 2024, Номер 14(11), С. 1071 - 1071

Опубликована: Окт. 27, 2024

Objective: This study aimed to investigate the potential associations between physical activity, sedentary behavior, and basal metabolic rate (BMR) with post-traumatic stress disorder (PTSD), major depressive (MDD), emotional instability (EI) using bidirectional Mendelian randomization (MR). Additionally, it sought identify key molecular mechanisms underlying through a comprehensive bioinformatic analysis. Methods: MR analyses utilizing genome-wide association (GWAS) data were conducted estimate effects of BMR on PTSD, MDD, EI. Sensitivity performed assess robustness findings. Concurrently, analysis was executed gene expression datasets (GSE53987 GSE21138) derived from emotionally unstable patients. encompassed differential differentially expressed genes (DEGs), followed by an functional enrichment uncover pathways associated Results: The revealed that increased activity may have protective effect against albeit inconsistent MDD Sedentary behavior demonstrated minimal or identified 114 DEGs EI, YWHAB, SRRM2, MST1, HDAC10, HSPA1A highlighted as significant genes. these unveiled potentially involved in pathology instability. Conclusions: Physical appears protect whereas its EI are less definitive. findings offer deeper understanding pinpointing specific serve therapeutic targets. Further research is warranted elucidate intricate interactions mechanisms.

Язык: Английский

Процитировано

0