Cytokine & Growth Factor Reviews, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Therapeutic Advances in Gastroenterology, Год журнала: 2025, Номер 18
Опубликована: Янв. 1, 2025
Colorectal cancer (CRC) remains a leading cause of cancer-related deaths worldwide, with its progression intricately linked to gut microbiota dysbiosis. Disruptions in microbial homeostasis contribute tumor initiation, immune suppression, and inflammation, establishing the as key therapeutic target. Fecal transplantation (FMT) has emerged transformative approach restore balance, enhance responses, reshape microenvironment. This review explores mechanisms underlying FMT’s potential, evaluates advantages over other microbiota-based interventions, addresses challenges such donor selection, safety concerns, treatment standardization. Looking forward, integration FMT into personalized CRC therapies requires robust clinical trials identification predictive biomarkers optimize efficacy safety.
Язык: Английский
Процитировано
0
Microorganisms, Год журнала: 2025, Номер 13(4), С. 814 - 814
Опубликована: Апрель 3, 2025
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and neuronal loss, affecting millions worldwide. Emerging evidence highlights the oral microbiome—a complex ecosystem of bacteria, fungi, viruses, protozoa as significant factor in health. Dysbiosis microbiome contributes to systemic inflammation, disrupts blood–brain barrier, promotes neuroinflammation, processes increasingly implicated pathogenesis AD. This review examines mechanisms linking dysbiosis through oral–brain oral–gut–brain axis. These interconnected pathways enable bidirectional communication between cavity, gut, brain via neural, immune, endocrine signaling. Oral pathogens, such Porphyromonas gingivalis, along with virulence factors, including lipopolysaccharides (LPS) gingipains, contribute while metabolic byproducts, short-chain fatty acids (SCFAs) peptidoglycans, further exacerbate immune activation. Additionally, this explores influence external diet, pH balance, medication use, smoking, alcohol consumption, hygiene, on microbial diversity stability, highlighting their role shaping outcomes. The dynamic interplay gut microbiomes reinforces importance homeostasis preserving neurological interventions, probiotics, prebiotics, dietary modifications, offer promising strategies support function reduce risk diseases, AD, maintaining diverse microbiome. Future longitudinal research needed identify long-term impact cognition.
Язык: Английский
Процитировано
0
Indian Journal of Neurotrauma, Год журнала: 2025, Номер unknown
Опубликована: Апрель 4, 2025
Abstract Introduction Traumatic brain injury (TBI) induces systemic alterations, including gut microbiome dysbiosis, increased intestinal permeability, and neuroinflammatory responses. This review explores the bidirectional gut-brain interactions, focusing on inflammation, potential therapeutic interventions. Materials Methods A comprehensive of preclinical human studies was conducted to assess microbiota changes following TBI. Key findings microbial shifts, markers, strategies were analyzed. Results Experimental animal models demonstrate that TBI leads loss short-chain fatty acid-producing bacteria, bacterial translocation due impaired barrier function. These alterations exacerbate cascades, microglial activation, cytokine release, oxidative stress. Dysbiosis-induced metabolic shifts influence tryptophan metabolism kynurenine pathway contributing excitotoxicity neurodegeneration. Human reveal persistent imbalances in severe patients, correlating with inflammation prolonged recovery. Conclusion Despite growing evidence linking neuroinflammation secondary injury, challenges remain translating clinical applications. Heterogeneity experimental models, variability assessment techniques, gaps mechanistic understanding hinder standardization. Emerging microbiome-targeted therapies, probiotics, offer promising avenues for modulating improving neurological recovery post-TBI. Further research is needed establish causal relationships, optimize strategies, evaluate long-term outcomes.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(8), С. 3658 - 3658
Опубликована: Апрель 12, 2025
This narrative review presents the role of antioxidants in regulating gut microbiota and impact on gut–brain axis, with a particular focus neurodegenerative diseases, such as Alzheimer’s (AD) Parkinson’s disease (PD). These diseases are characterised by cognitive decline, motor dysfunction, neuroinflammation, all which significantly exacerbated oxidative stress. elucidates contribution damage to progression explores potential mitigate these pathological processes through modulation associated pathways. Based recent studies retrieved from reputable databases, including PubMed, Web Science, Scopus, this article outlines mechanisms influence health exert neuroprotective effects. Specifically, it discusses how antioxidants, polyphenols, vitamins, flavonoids, contribute reduction reactive oxygen species (ROS) production thereby promoting neuronal survival minimising brain. In addition, modulating key molecular pathways involved stress NF-κB, Nrf2, MAPK, PI3K/AKT pathways, regulate ROS generation, inflammatory cytokine expression, antioxidant responses essential for maintaining cellular homeostasis both central nervous system. complex relationship between gut-derived metabolites, stress, highlighting dysbiosis—an imbalance microbiota—can exacerbate accelerating AD PD. The also examines short-chain fatty acids (SCFAs) produced beneficial bacteria attenuate neuroinflammation damage. Furthermore, therapeutic microbiota-targeted interventions, delivery probiotics prebiotics, innovative strategies restore microbial support brain health. By synthesising current knowledge interplay underlying neurodegeneration, highlights promise antioxidant-based interventions mitigating progression. It need further research into antioxidant-rich dietary microbiota-focused therapies promising avenues prevention treatment diseases.
Язык: Английский
Процитировано
0
Cytokine & Growth Factor Reviews, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0