Bamboo Leaf Flavonoids from Phyllostachys glauca McClure Suppress the Progression of Alzheimer’s Disease Induced by Circadian Rhythm Disruption Through Regulating Hif3α/Rab7/TNFα/IL1β Pathway

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3169 - 3169

Опубликована: Март 29, 2025

Circadian rhythm disruption is a modifiable risk factor for Alzheimer’s disease (AD) progression, marked by neuroinflammation, oxidative stress, and amyloid-β (Aβ) accumulation. Hypoxia-inducible 3α (Hif3α) has emerged as key regulator of inflammatory pathways. To evaluate the impacts circadian on AD progression investigate therapeutic potential bamboo leaf flavonoids (BLFs), C57BL/6N mice (normal mice) APP/PS1 transgenic (AD were exposed to via randomized light exposure in vivo model. Then, BLFs administered assess effects organ damage. Next, Nissl body staining Aβ protein immunohistochemistry performed brain pathology. Through transcriptome sequencing, factors related pathway screened out. In vitro, molecular mechanisms explored PC12 cells treated with Aβ42 Hif3α siRNA fragments. Results demonstrated that increased stress early liver kidney damage degrees, greater severity mice. partially reversed reduced deposition. Transcriptome analysis revealed upregulation circadian-disrupted mice, linked inflammation stress. knockdown normalized expression, which could be regulated suppressed progression. conclusion, exacerbated regulating Hif3α/Rab7/TNFα/IL1β pathway. offered neuroprotection roles mitigating damage, highlighting promising target therapy biomarker development.

Язык: Английский

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Association between hemoglobin-to-red blood cell distribution width ratio and cognitive function in older US adults: a cross-sectional study based on the NHANES 2011–2014

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Апрель 14, 2025

Introduction The hemoglobin-to-red blood cell distribution width ratio (HRR) is acknowledged as a promising new prognostic biomarker. Nevertheless, investigations into its connection with cognitive function have yielded unclear results. Aim This study aimed to investigate the association between and in older adults United States. Methods utilized data obtained from NHANES database, encompassing years 2011 2014. participant cohort consisted of elderly individuals aged 60 older, all whom underwent thorough assessments function, hemoglobin levels, red width. We employed weighted logistic regression analysis, along restricted cubic spline (RCS) curves subgroup analyses, rigorously evaluate function. Results encompassed total 2,520 participants, mean age 69.44 ± 6.76 years. After adjusting for multiple covariates, analysis indicated significant linear impairment HRR Specifically, each one-unit increase was associated an 82% reduction probability among participants (OR = 0.18, 95% CI: 0.04–0.78). relationship remained exist after categorized tertiles. Participants highest tertile exhibited 42% lower likelihood compared those lowest 0.58; 0.37–0.91, p 0.022). To validate robustness our findings, we conducted which consistently demonstrated stable results across evaluated groups. Conclusion cross-sectional revealed negative correlation

Язык: Английский

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Homocysteine Mediates Cognitive Inflexibility Induced by Stress via Targeting PIN1

Brain Sciences, Год журнала: 2025, Номер 15(4), С. 416 - 416

Опубликована: Апрель 19, 2025

Increasing evidence shows that HCY plays an important role in stress-induced cognitive dysfunction, and significantly promotes the decline of function. Stress has been reported to cause elevated hippocampus mice. Cognitive flexibility refers ability individuals quickly adjust their neurobehavioral strategies different situations or solve tasks. This study aims explore impairment induced by stress its possible regulatory mechanism. First, we examined changes protein mRNA levels effector molecule, PIN1, during The results show can a mice lead increase PIN1. Moreover, through use vitro experiments, found could induce PIN1 expression neurons. Further vivo experiments were used investigate effect VitB on evaluated therapeutic flexibility. decreased plasma hippocampus, alleviated flexibility, reduced These suggest be inhibited regulating content HCY. Collectively, our findings highlight aimed at improving treatment for impairments

Язык: Английский

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The protective effects of Araucaria angustifolia (Bertol.) on neurodegeneration induced by LPS and kynurenine exposure in BV-2 microglial cells

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Май 30, 2025

Язык: Английский

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