Frontiers in Medicine,
Год журнала:
2024,
Номер
11
Опубликована: Июнь 27, 2024
Objectives
To
investigate
the
value
of
interpretable
machine
learning
model
and
nomogram
based
on
clinical
factors,
MRI
imaging
features,
radiomic
features
to
predict
Ki-67
expression
in
primary
central
nervous
system
lymphomas
(PCNSL).
Materials
methods
images
information
92
PCNSL
patients
were
retrospectively
collected,
which
divided
into
53
cases
training
set
39
external
validation
according
different
medical
centers.
A
3D
brain
tumor
segmentation
was
trained
nnU-NetV2,
two
prediction
models,
Random
Forest
(RF)
incorporating
SHapley
Additive
exPlanations
(SHAP)
method
multivariate
logistic
regression,
proposed
for
task
status
prediction.
Results
The
mean
dice
Similarity
Coefficient
(DSC)
score
0.85.
On
task,
AUC
RF
0.84
(95%
CI:0.81,
0.86;
p
<
0.001),
a
3%
improvement
compared
nomogram.
Delong
test
showed
that
z
statistic
difference
between
models
1.901,
corresponding
0.057.
In
addition,
SHAP
analysis
Rad-Score
made
significant
contribution
decision.
Conclusion
this
study,
we
developed
used
an
preoperative
patients,
improved
task.
Clinical
relevance
statement
represents
degree
active
cell
proliferation
is
important
prognostic
parameter
associated
with
outcomes.
Non-invasive
accurate
level
preoperatively
plays
role
targeting
treatment
selection
patient
stratification
management
thereby
improving
prognosis.
Physics in Medicine and Biology,
Год журнала:
2024,
Номер
69(2), С. 025012 - 025012
Опубликована: Янв. 10, 2024
Abstract
Coronary
vessel
segmentation
plays
a
pivotal
role
in
automating
the
auxiliary
diagnosis
of
coronary
heart
disease.
The
continuity
and
boundary
accuracy
segmented
vessels
directly
affect
subsequent
processing.
Notably,
during
segmentation,
with
severe
stenosis
can
easily
cause
errors
breakage,
resulting
isolated
islands.
To
address
these
issues,
we
propose
novel
multi-scale
U-shaped
transformer
aggregation
topology
preservation
(UT-BTNet)
for
angiography.
Specifically,
considering
characteristics
vessels,
first
develop
UT-BTNet
which
combines
advantages
convolutional
neural
networks
(CNN)
transformer,
is
able
to
effectively
extract
local
global
features
angiographic
images.
Secondly,
innovatively
employ
loss
topological
two
stages,
addition
traditional
losses.
In
stage,
adopted,
has
effect
aggregation.
second
applied
preserve
after
network
converges.
experiment,
metrics
Dice
intersection
over
union
(IoU),
specifically
(BIoU)
Betti
error
evaluate
results.
results
show
that
0.9291,
IoU
0.8687,
BIoU
0.5094,
0.3400.
Compared
other
state-of-the-art
methods,
achieves
better
results,
while
ensuring
indicating
its
potential
clinical
value.
Diagnostics,
Год журнала:
2024,
Номер
14(12), С. 1213 - 1213
Опубликована: Июнь 7, 2024
Deep
learning
has
attained
state-of-the-art
results
in
general
image
segmentation
problems;
however,
it
requires
a
substantial
number
of
annotated
images
to
achieve
the
desired
outcomes.
In
medical
field,
availability
is
often
limited.
To
address
this
challenge,
few-shot
techniques
have
been
successfully
adapted
rapidly
generalize
new
tasks
with
only
few
samples,
leveraging
prior
knowledge.
paper,
we
employ
gradient-based
method
known
as
Model-Agnostic
Meta-Learning
(MAML)
for
segmentation.
MAML
meta-learning
algorithm
that
quickly
adapts
by
updating
model’s
parameters
based
on
limited
set
training
samples.
Additionally,
use
an
enhanced
3D
U-Net
foundational
network
our
models.
The
convolutional
neural
specifically
designed
We
evaluate
approach
TotalSegmentator
dataset,
considering
four
tasks:
liver,
spleen,
right
kidney,
and
left
kidney.
demonstrate
facilitates
rapid
adaptation
using
images.
10-shot
settings,
achieved
mean
dice
coefficients
93.70%,
85.98%,
81.20%,
89.58%
kidney
segmentation,
respectively.
five-shot
sittings,
Dice
90.27%,
83.89%,
77.53%,
87.01%
Finally,
assess
effectiveness
proposed
dataset
collected
from
local
hospital.
Employing
90.62%,
79.86%,
79.87%,
78.21%
This
chapter
analyzes
the
evolving
landscape
of
medical
image
analysis,
with
a
particular
emphasis
on
research-driven
incorporation
deep
learning
models.
The
paradigm
change
caused
by
these
models
is
investigated
in
consideration
its
applicability
disease
detection,
diagnosis,
and
treatment
planning.
focuses
crucial
function
segmentation
detecting
characterizing
anomalies
across
various
imaging
modalities.
From
clinical
significance
to
precision
medicine,
impacts
precise
are
special
role
specific
plans
actions
because
problems
that
exist
this
field,
such
as
limited
data
availability
computation
limits,
proposes
collaborative
techniques
address
them.
aims
solve
present
constraints
envisioning
future
defined
advanced
augmentation,
domain
adaptation,
multi-modal
fusion,
paving
way
for
more
robust
widely
applicable
analysis.
overall
goal
encourage
responsible
development
implementation,
which
will
lead
improvements
patient
outcomes
healthcare
diagnostics
Neurocomputing,
Год журнала:
2024,
Номер
577, С. 127379 - 127379
Опубликована: Фев. 6, 2024
Despite
the
extensive
utilization
of
deep
learning
in
medical
image
segmentation,
achieved
accuracy
remains
inadequate
for
clinical
requirements
due
to
scarcity
annotated
data,
which
constrains
acquisition
anatomical
knowledge.
Leveraging
information
is
particularly
advantageous
especially
multi-modal
and
cross-domain
tasks.
To
better
capture
represent
structures,
we
propose
a
Swin
Transformer-based
structure-aware
network,
AnatSwin,
adopts
unique
approach
by
utilizing
label
images
as
inputs.
Compared
with
gray-scale
images,
devoid
intensity
information,
explicitly
enhance
representation
shape
spatial
tissue
relationships,
offering
valuable
resources
structures
effectively
allowing
model
concentrate
on
understanding
morphological
relationship
cues.
AnatSwin
follows
an
encoder–decoder
architecture,
where
encoder
incorporates
two
branches
that
share
weights.
The
Swin-Transformer
block
serves
basic
unit
encoder,
accepting
both
template
(representing
correct
structure)
pseudo
(generated
registration
model)
In
order
facilitate
efficient
interaction
among
features
at
same
hierarchy,
attention-based
feature
(FI)
introduced.
FI
enhances
model's
ability
structure
promoting
interactions
within
branches.
Furthermore,
decoder
employs
blocks
learn
relationships
between
ultimately
improving
segmentation
performance.
Experimental
evaluations
demonstrate
proposed
outperforms
state-of-the-art
models,
highlighting
its
significant
potential
well
optimizing
tasks
related
segmentation.
This
work
signifies
promising
step
forward
addressing
challenges
paves
way
further
advancements
field.
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Март 27, 2025
Introduction
Accurate
segmentation
of
lesion
tissues
in
medical
microscopic
hyperspectral
pathological
images
is
crucial
for
enhancing
early
tumor
diagnosis
and
improving
patient
prognosis.
However,
the
complex
structure
indistinct
boundaries
present
significant
challenges
achieving
precise
segmentation.
Methods
To
address
these
challenges,
we
propose
a
novel
method
named
BE-Net.
It
employs
multi-scale
strategy
edge
operators
to
capture
fine
details,
while
incorporating
information
entropy
construct
attention
mechanisms
that
further
strengthen
representation
relevant
features.
Specifically,
first
Laplacian
Gaussian
operator
convolution
boundary
feature
extraction
block,
which
encodes
gradient
through
improved
detection
emphasizes
channel
weights
based
on
weighting.
We
designed
grouped
module
optimize
fusion
process
between
encoder
decoder,
with
goal
details
emphasizing
representations.
Finally,
spatial
block
guide
model
most
important
locations
regions.
Result
evaluate
BE-Net
image
datasets
gastric
intraepithelial
neoplasia
mucosal
intestinal
metaplasia.
Experimental
results
demonstrate
outperforms
other
state-of-the-art
methods
terms
accuracy
preservation.
Discussion
This
advance
has
implications
field
MHSIs
Our
code
freely
available
at
https://github.com/sharycao/BE-NET
.