Is H19 RNA a Useful Marker of Acromegaly and Its Complications? A Preliminary Study DOI Creative Commons
Małgorzata Rolla, Aleksandra Jawiarczyk-Przybyłowska, Katarzyna Kolačkov

и другие.

Biomedicines, Год журнала: 2023, Номер 11(4), С. 1211 - 1211

Опубликована: Апрель 19, 2023

Acromegaly is a rare endocrine disorder caused by somatotroph pituitary adenoma. Besides its typical symptoms, it contributes to the development of cardiovascular, metabolic, and bone comorbidities. H19 RNA long non-coding suspected be involved in tumorigenesis, cancer progression, metastasis. novel biomarker for diagnosis monitoring neoplasms. Moreover, there might an association between cardiovascular metabolic diseases. We enrolled 32 acromegaly patients 25 controls. investigated whether whole blood expression associated with acromegaly. Correlations tumour dimension, invasiveness, biochemical hormonal parameters were evaluated. analysed coincidence comorbidities expression. In results, we did not observe statistically significant difference There no correlations adenoma size infiltration patients' statuses. group, hypertension, goitre, cholelithiasis observed more frequently. The was factor contributing occurrence dyslipidaemia, cholelithiasis. found patients. To conclude, relevant marker higher risk related Cholelithiasis

Язык: Английский

The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases DOI Creative Commons
Denise Busscher, Reinier A. Boon, Rio P. Juni

и другие.

Clinical Science, Год журнала: 2022, Номер 136(15), С. 1157 - 1178

Опубликована: Авг. 1, 2022

Abstract Cardiovascular diseases are the leading cause of death and debility worldwide. Various molecular mechanisms have been studied to better understand development progression cardiovascular pathologies with hope eradicate these diseases. With advancement sequencing technology, it is revealed that majority our genome non-coding. A growing body literature demonstrates critical role long non-coding RNAs (lncRNAs) as epigenetic regulators gene expression. LncRNAs can regulate cellular biological processes through various distinct mechanisms. The abundance lncRNAs in system indicates their significance physiology pathology. LncRNA H19, particular, a highly evolutionarily conserved lncRNA enriched cardiac vascular tissue, underlining its importance maintaining homeostasis system. In this review, we discuss versatile function H19 types We highlight current on demonstrate how dysregulation induces pathophysiology.

Язык: Английский

Процитировано

46
The emerging roles of long non-coding RNA (lncRNA) H19 in gynecologic cancers DOI Creative Commons
Majid Ghasemian,

Mojtaba Zehtabi,

Mahrokh Abouali Gale Dari

и другие.

BMC Cancer, Год журнала: 2024, Номер 24(1)

Опубликована: Янв. 2, 2024

Long non-coding RNA (lncRNA) H19 has gained significant recognition as a pivotal contributor to the initiation and advancement of gynecologic cancers, encompassing ovarian, endometrial, cervical, breast cancers. exhibits complex array mechanisms, demonstrating dualistic effects on tumorigenesis it can function both an oncogene tumor suppressor, contingent upon specific context type cancer being investigated. In ovarian cancer, promotes growth, metastasis, chemoresistance through modulation key signaling pathways interaction with microRNAs. Conversely, in endometrial acts suppressor by inhibiting proliferation, inducing apoptosis, regulating epithelial-mesenchymal transition. Additionally, been implicated cervical where influences cell invasion, immune evasion. Moreover, potential diagnostic prognostic biomarker for its expression levels correlating clinical parameters patient outcomes. Understanding functional roles cancers is crucial development targeted therapeutic strategies personalized treatment approaches. Further investigation into intricate molecular mechanisms underlying H19's involvement malignancies warranted fully unravel implications. This review aims elucidate various malignancies.

Язык: Английский

Процитировано

9
Role of primary aging hallmarks in Alzheimer´s disease DOI Creative Commons
Jin Zhao, Jisen Huai

Theranostics, Год журнала: 2022, Номер 13(1), С. 197 - 230

Опубликована: Ноя. 29, 2022

Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely threatens health of elderly and causes significant economic social burdens.The AD are complex include heritable but mostly aging-related factors.The primary aging hallmarks genomic instability, telomere wear, epigenetic changes, loss protein stability, play a dominant role in process.Although closely associated with process, underlying mechanisms involved pathogenesis have not been well characterized.This review summarizes available literature about their roles pathogenesis.By analyzing published literature, we attempted to uncover possible aberrant markers related enzymes, transcription factors, proteostasis AD.In particular, importance oxidative stress-induced DNA methylation methylation-directed histone modifications highlighted.A molecular network gene regulatory elements that undergoes dynamic change age may underlie age-dependent pathogenesis, can be used as new drug target treat AD.

Язык: Английский

Процитировано

29
Dendrimers in the context of targeting central nervous system disorders DOI

Forum Palan,

Bappaditya Chatterjee

Journal of Drug Delivery Science and Technology, Год журнала: 2022, Номер 73, С. 103474 - 103474

Опубликована: Май 31, 2022

Язык: Английский

Процитировано

17
Emerging Roles of miRNA, lncRNA, circRNA, and Their Cross-Talk in Pituitary Adenoma DOI Creative Commons
Wentao Wu, Lei Cao, Yanfei Jia

и другие.

Cells, Год журнала: 2022, Номер 11(18), С. 2920 - 2920

Опубликована: Сен. 19, 2022

Pituitary adenoma (PA) is a common intracranial tumor without specific biomarkers for diagnosis and treatment. Non-coding RNAs (ncRNAs), including microRNAs (miRNA), long non-coding RNA (lncRNA), circular (circRNA), regulate variety of cellular processes, such as cell proliferation, differentiation, apoptosis. Increasing studies have shown that the dysregulation ncRNAs, especially cross-talk between lncRNA/circRNA miRNA, related to pathogenesis, diagnosis, prognosis PA. Therefore, ncRNAs can be considered promising In this review, we summarize roles from different specimens (i.e., tissues, biofluids, cells, exosomes) in multiple subtypes PA highlight important advances understanding contribution (e.g., competing endogenous RNAs) disease.

Язык: Английский

Процитировано

16
Aucubin Promotes Osteogenic Differentiation and Facilitates Bone Formation through the lncRNA-H19 Driven Wnt/β-Catenin Signaling Regulatory Axis DOI Creative Commons
Yongxin Mai, Zhipeng Li,

Fengxiang Pang

и другие.

Stem Cells International, Год журнала: 2024, Номер 2024(1)

Опубликована: Янв. 1, 2024

Traditional Chinese medicine

Язык: Английский

Процитировано

3
Up-regulation of long non-coding RNA H19 ameliorates renal tubulointerstitial fibrosis by reducing lipid deposition and inflammatory response through regulation of the microRNA-130a-3p/long-chain acyl-CoA synthetase 1 axis DOI Creative Commons
Yali Jiang,

Feng Ma,

Jing Wang

и другие.

Non-coding RNA Research, Год журнала: 2024, Номер 9(4), С. 1120 - 1132

Опубликована: Май 9, 2024

Long non-coding RNA (lncRNA) H19 is an extensively studied lncRNA that related to numerous pathological changes. Our previous findings have documented serum levels are decreased in patients with chronic kidney disorder and reduction closely correlated renal tubulointerstitial fibrosis, essential step developing end-stage disease. Nonetheless, the precise function mechanism of fibrosis not fully comprehended. The present work utilized a mouse model unilateral ureteral obstruction (UUO) transforming growth factor-β1 (TGF-β1)-stimulated HK-2 cells investigate possible role were investigated. Levels kidneys mice UUO stimulated TGF-β1. Up-regulation remarkably relieved injury, inflammation triggered by UUO. Moreover, increase reduced epithelial-to-mesenchymal transition (EMT) induced Notably, up-regulation lipid accumulation triacylglycerol content TGF-β1-stimulated cells, accompanied long-chain acyl-CoA synthetase 1 (ACSL1). was identified as sponge microRNA-130a-3p, through which modulates expression ACSL1. overexpression microRNA-130a-3p reversed H19-induced increases suppressive effects on EMT, diminished ACSL1 silencing or overexpression. Overall, showed ameliorated reducing deposition via modulation microRNA-130a-3p/ACSL1 axis.

Язык: Английский

Процитировано

3
Long noncoding RNA H19 knockdown promotes angiogenesis via IMP2 after ischemic stroke DOI Creative Commons
Liyuan Zhong, Junfen Fan, Feng Yan

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(8)

Опубликована: Авг. 1, 2024

This study aimed to explore the effects of long noncoding RNA (lncRNA) H19 knockdown on angiogenesis and blood-brain barrier (BBB) integrity following cerebral ischemia/reperfusion (I/R) elucidate their underlying regulatory mechanisms.

Язык: Английский

Процитировано

3
H19/miR‐484 axis serves as a candidate biomarker correlated with autism spectrum disorder DOI Open Access
Yancai Li, Chunlong Liu,

Qianqi Jin

и другие.

International Journal of Developmental Neuroscience, Год журнала: 2025, Номер 85(1)

Опубликована: Янв. 3, 2025

Abstract Background Autism spectrum disorder (ASD) appears to be a common neurological developmental deficit in pediatric patients, resulting tremendous burden on society. Purpose The article aimed explore early diagnostic markers for ASD. Methods Levels of long non‐coding RNA (lncRNA) H19 and microRNA‐484 (miR‐484) were detected using fluorescence quantitative polymerase chain reaction (PCR). Spearman method was applied the correlation analysis with ASD severity. To evaluate role miR‐484 diagnosis, receiver operator characteristic (ROC) curve plotted. Luciferase reporter assay used confirm targeting relationship between miR‐484. functions pathways related target genes annotated by Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analysis. Results Elevated levels which positively correlated disease MiR‐484 showed decreasing trend while it negatively Both can distinguish cases from controls an AUC 0.878 0.868, respectively. determined miR‐484., their combination highest value (AUC = 0.906). GO KEGG demonstrated targeted development ASD, EIF4G2 SMARCA2 main core genes. Conclusion dysregulated patients both associated combined represented high

Язык: Английский

Процитировано

0
Cell-Free Nucleic Acids for Early Diagnosis of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis DOI Open Access
Xiaodan Zhang, Yuzhou Cai, Brian Sit

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1530 - 1530

Опубликована: Фев. 12, 2025

Rapid identification of acute ischemic stroke (AIS) is challenging in both pre-hospital and hospital settings. We aimed to identify the most promising cell-free nucleic acids (cfNAs) as diagnostic biomarkers for IS within 72 h from symptom onset. searched PubMed, Web Science, EMBASE, Cochrane Library published articles that evaluated blood cfNAs early diagnosis AIS until 10 May 2023. The performances individual were pooled by random-effects meta-analysis based on fold change biomarkers' level between non-AIS patients. Of 2955 records, 66 reporting 143 different met inclusion criteria. median sample size was 110, 21.4% studies performed validation. Among selected high-quality studies, miR-106b-5p, miR-124, miR-155, lncRNA H19, cfDNA showed good performance. Data four involving 355 patients 97 controls meta-analysis, which a significant (pooled ratio 1.48, 95% confidence interval 1.23-1.79, p < 0.001). This review highlights cfDNA, H19 are diagnosis, further research needed verification.

Язык: Английский

Процитировано

0