Pathology - Research and Practice, Год журнала: 2023, Номер 242, С. 154330 - 154330
Опубликована: Янв. 21, 2023
Язык: Английский
Developmental Neuroscience, Год журнала: 2022, Номер 44(4-5), С. 331 - 343
Опубликована: Янв. 1, 2022
Therapeutic hypothermia (TH) is now a standard treatment for infants with moderate-to-severe neonatal encephalopathy (NE), and improves brain damage on neuroimaging neurodevelopmental outcomes. Critically, effective neuroprotection, should be started within 6 h from birth. There compelling evidence to suggest that proportion of mild NE have material risk developing poor This cohort increasingly being offered TH, despite lack trial its benefit. In current practice, need diagnosed birth therapeutic treatment, compared retrospective grading in the pre-hypothermia era. presents challenges as dynamic disorder can worsen or resolve over time. Neurological symptoms difficult discern first few hours after birth, confounded by analgesics anesthetic treatment. Using enrolment criteria, significant number would benefit are not treated, vice versa, some receive when will limited. Better biomarkers needed further improve management these neonates. present review, we examine latest research, highlight central limitation most biomarkers: their predictive value consistently greatest neuroprotective therapies no longer effective.
Язык: Английский
Процитировано
11
Cell & Bioscience, Год журнала: 2024, Номер 14(1)
Опубликована: Июнь 25, 2024
Abstract Polyamines (PA) are polycations with pleiotropic functions in cellular physiology and pathology. In particular, PA have been involved the regulation of cell homeostasis proliferation participating control fundamental processes like DNA transcription, RNA translation, protein hypusination, autophagy modulation ion channels. Indeed, their dysregulation has associated to inflammation, oxidative stress, neurodegeneration cancer progression. Accordingly, intracellular levels, derived from balance between uptake, biosynthesis, catabolism, need be tightly regulated. Among mechanisms that fine-tune metabolic enzymes, emerging findings highlight importance noncoding RNAs (ncRNAs). ncRNAs, microRNA, long circRNA most studied as regulators gene expression mRNA metabolism alteration frequently reported pathological conditions, such progression brain diseases. this review, we will discuss role ncRNAs genes, a particular emphasis on changes observed health disorders.
Язык: Английский
Процитировано
2
Experimental Neurology, Год журнала: 2022, Номер 352, С. 114032 - 114032
Опубликована: Март 5, 2022
Язык: Английский
Процитировано
8
Scientific Reports, Год журнала: 2023, Номер 13(1)
Опубликована: Июнь 7, 2023
Wilson's disease (WD) is an autosomal recessive disorder with a genetic basis. The predominant non-motor symptom of WD cognitive dysfunction, although the specific regulatory mechanism remains unclear. Tx-J mice, 82% sequence homology ATP7B gene to human gene, are considered most suitable model for WD. This study employs deep sequencing investigate differences in RNA transcript profiles, both coding and non-coding, as well functional characteristics network involved impairment. function tx-J mice was evaluated using Water Maze Test (WMT). Long non-coding (lncRNA), circular (circRNA), messenger (mRNA) profiles were analyzed hippocampal tissue identify differentially expressed RNAs (DE-RNAs). Subsequently, DE-RNAs used construct protein-protein interaction (PPI) networks, DE-circRNAs lncRNAs-associated competing endogenous (ceRNA) expression coding-noncoding co-expression (CNC) networks. To elucidate their biological functions pathways, PPI ceRNA networks subjected Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway analysis. A total 361 mRNAs (DE-mRNAs), comprising 193 up-regulated 168 down-regulated mRNAs, 2627 long (DE-lncRNAs), consisting 1270 1357 lncRNAs, 99 (DE-circRNAs), 68 31 circRNAs, observed group when compared control group. analyses revealed that DE-mRNAs enriched cellular processes, calcium signaling mRNA surveillance pathways. In contrast, DE-circRNAs-associated covalent chromatin modification, histone axon guidance, whereas DE-lncRNAs-associated dendritic spine, regulation cell morphogenesis differentiation, pathway. presented lncRNA, circRNA, mice. Furthermore, constructed PPI, ceRNA, CNC findings significant comprehending genes associated These results also offer valuable information diagnosis treatment
Язык: Английский
Процитировано
3
Pathology - Research and Practice, Год журнала: 2023, Номер 242, С. 154330 - 154330
Опубликована: Янв. 21, 2023
Язык: Английский
Процитировано
3