The role of brain derived neurotrophic factor in central nervous system

Frontiers in Aging Neuroscience, Год журнала: 2022, Номер 14

Опубликована: Сен. 8, 2022

Brain derived neurotrophic factor (BDNF) has multiple biological functions which are mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) and p75 neurotrophin receptor, involving in physiological pathological processes throughout life. The diverse presence activity BDNF indicate its potential role pathogenesis, progression treatment both neurological psychiatric disorders. This review is to provide a comprehensive assessment current knowledge future directions BDNF-associated research central nervous system (CNS), with an emphasis on as well effects CNS diseases, including depression, Alzheimer’s disease, Parkinson’s Huntington’s amyotrophic lateral sclerosis, cerebral ischemic stroke.

Язык: Английский

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The role of polyunsaturated fatty acids in neuronal signaling in depression and cognitive processes

Archives of Biochemistry and Biophysics, Год журнала: 2023, Номер 737, С. 109555 - 109555

Опубликована: Фев. 24, 2023

Язык: Английский

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Postsynaptic Proteins at Excitatory Synapses in the Brain—Relationship with Depressive Disorders

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(19), С. 11423 - 11423

Опубликована: Сен. 28, 2022

Depressive disorders (DDs) are an increasingly common health problem that affects all age groups. DDs pathogenesis is multifactorial. However, it was proven stress one of the most important environmental factors contributing to development these conditions. In recent years, there has been growing interest in role glutamatergic system context pharmacotherapy DDs. Thus, become explore functioning excitatory synapses and pharmacological treatment psychiatric (including DDs). This knowledge may lead description new mechanisms depression indicate potential targets for illness. An synapse a highly complex very dynamic structure, containing vast number proteins. review aimed discuss detail key postsynaptic proteins (e.g., NMDAR, AMPAR, mGluR5, PSD-95, Homer, NOS etc.) systematize about changes occur clinical course after antidepressant treatment. addition, discussion on use ligands and/or modulators at presented.

Язык: Английский

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Regulatory Molecules of Synaptic Plasticity in Anxiety Disorder

International Journal of General Medicine, Год журнала: 2023, Номер Volume 16, С. 2877 - 2886

Опубликована: Июль 1, 2023

Abstract: Synaptic plasticity is the capacity of synaptic transmission between neurons to be strengthened or weakened. There are many signal molecules accumulated in presynaptic and postsynaptic membranes that can lead regulation involvement numerous neurological psychiatric diseases, including anxiety disorder. However, regulatory mechanisms development disorder have not been well summarized. This review mainly aims discuss biological functions plasticity-related disorder, with a particular focus on metabotropic glutamate receptors, brain-derived neurotrophic factor, hyperpolarization-activated cyclic nucleotide–gated channels, density 95. The summarized will provide insight into novel neuroplasticity modifications for targeted therapy anxiety. Keywords: plasticity, anxiety, mGluRs, BDNF, HCN, PSD95

Язык: Английский

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Physicochemical Principles of Adhesion Mechanisms in the Brain

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(6), С. 5070 - 5070

Опубликована: Март 7, 2023

The brain functions through neuronal circuits and networks that are synaptically connected. This type of connection can exist due to physical forces interact stabilize local contacts in the brain. Adhesion is a fundamental phenomenon allows different layers, phases, tissues connect. Similarly, synaptic connections stabilized by specialized adhesion proteins. review discusses basic chemical properties adhesion. Cell molecules (CAMs) such as cadherins, integrins, selectins, immunoglobulin family cell (IgSF) will be discussed, their role physiological pathological function. Finally, CAMs at synapse described. In addition, methods for studying presented.

Язык: Английский

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Changes in working memory induced by lipopolysaccharide administration in mice are associated with metabotropic glutamate receptors 5 and contrast with changes induced by cyclooxygenase-2: Involvement of postsynaptic density protein 95 and down syndrome cell adhesion molecule

Neuropeptides, Год журнала: 2023, Номер 100, С. 102347 - 102347

Опубликована: Май 9, 2023

Язык: Английский

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Cyclooxygenase-2 inhibition affects the ratio of GluN2A/GluN2B receptor subunits through interaction with mGluR5 in the mouse brain

Neuropeptides, Год журнала: 2024, Номер 104, С. 102409 - 102409

Опубликована: Янв. 17, 2024

Язык: Английский

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