Flavour and Fragrance Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
ABSTRACT
In
this
study,
the
mechanism
of
Forsythia
suspensa
essential
oil
(FSEO)
on
cognitive
disorders
was
investigated
based
network
pharmacology
and
animal
experiments.
The
common
targets
AD
diseases
main
components
FSEO
were
collected
through
GeneCards,
PubChem,
STRING
other
databases,
protein–protein
interaction
(PPI)
maps
established.
GO
functional
enrichment
analysis
KEGG
pathway
performed
using
DAVID
Metascape
results
verified
scopolamine
(SCO)
impairment
mouse
model.
pharmacological
showed
that
involved
107
potential
therapeutic
targets,
among
which
MAPK1,
MAPK3
ESR1
core
closely
related
to
regulatory
pathways
MAPK
cascade,
5‐hydroxytryptaminergic
synapses,
dopaminergic
synapses
oxidoreductase
activity.
experiments
improved
cognitively
impaired
behaviours,
reduced
central
cholinergic
neuron
damage
oxidative
stress
in
brain
increased
content
monoamine
transmitters
brain.
Animal
further
validated
analysis.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(5), С. 615 - 615
Опубликована: Май 10, 2024
The
relapse
rate
of
substance
abusers
is
high,
and
addiction
rehabilitation
adjunct
drugs
need
to
be
developed
urgently.
There
have
been
numerous
reports
on
blocking
the
formation
addiction,
but
studies
that
can
alleviate
withdrawal
symptoms
are
very
limited.
Both
dopamine
transporter
(DAT)
hypothesis
D3
receptor
(D3R)
proposed.
DAT
activators
reduce
extracellular
level,
D3R
antagonists
neuron’s
sensitivity
dopamine,
both
which
may
exacerbate
subsequently.
partial
agonist
SK608
has
biased
signaling
properties
via
G-protein-dependent
pathway
did
not
induce
desensitization
and,
thus,
a
promising
drug
for
symptoms.
Drugs
serotoninergic
neurons
or
GABAergic
anti-inflammatory
auxiliary
effects
treatments.
promote
structural
synaptic
plasticity
also
discussed.
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Ноя. 22, 2024
Methamphetamine
(METH)
is
one
of
the
most
widely
abused
illicit
drugs
globally.
Despite
its
widespread
abuse,
effects
methamphetamine
on
brain
and
precise
mechanisms
underlying
addiction
remain
poorly
understood.
Elucidating
these
biological
developing
effective
treatments
utmost
importance.
Researchers
have
adopted
a
multi-faceted
approach,
combining
studies
at
genetic,
molecular,
organ,
individual
levels,
to
explore
epigenetic
changes
that
use
brings
an
organism
from
both
micro
macro
perspectives.
They
utilize
comparative
analysis
experimental
animal
data
clinical
cases
ascertain
differences
identify
potential
targets
for
translating
METH
research
setting.
Recent
demonstrated
regulation
plays
pivotal
role
in
neural
mechanisms,
encompassing
DNA
methylation,
histone
modifications
(such
as
acetylation
methylation),
ubiquitination,
phosphorylation,
non-coding
RNA.
These
factors
influence
individual’s
susceptibility
response
by
regulating
expression
specific
genes.
Specifically,
has
been
observed
cause
alterations
methylation
status,
which
turn
affects
genes
associated
with
neuroreward
pathways,
leading
function
structure.
Furthermore,
significant
implications
neurotoxicity
addiction.
For
instance,
H3
modify
chromatin
structure,
consequently
influencing
transcriptional
activity
Non-coding
RNAs,
including
microRNAs
(miRNAs)
long
RNAs
(lncRNAs),
also
play
interacting
messenger
(mRNAs)
gene
expression.
To
further
advance
our
understanding,
researchers
employ
advanced
technologies
such
high-throughput
sequencing,
immunoprecipitation
sequencing
(ChIP-seq),
RNA
(RNA-seq)
comprehensively
analyze
models
human
subjects.
enable
markers
their
functional
consequences.
This
article
reviews
discusses
future
treatment
strategies,
particularly
development
targeting
By
deepening
comprehension
regulatory
it
anticipated
targeted
therapeutic
strategies
may
be
devised
reverse
addiction,
thus
enhancing
efficacy
paving
way
this
domain.
Future Pharmacology,
Год журнала:
2024,
Номер
4(1), С. 115 - 138
Опубликована: Янв. 29, 2024
Addiction
is
a
complex
brain
disease
influenced
by
genetic,
environmental,
and
neurological
factors.
Psychostimulants,
cocaine,
methamphetamine
influence
different
cell
types
in
regions,
with
focus
on
the
neurons
responsible
for
rewarding
effects
nucleus
accumbens
(NAc)
ventral
tegmental
area
(VTA).
Known
markers
psychostimulant-induced
neuronal
plasticity
combination
droplet-based
high-throughput
single-cell
sequencing
divided
heterogeneity
of
populations
NAc
VTA
into
clusters,
where
all
cells
same
type
do
not
respond
equally
to
exposure
psychostimulants.
To
explain
as
changes
amplitude
phase
shifts
gene
expression,
we
focused
epigenetic
mechanisms
DNA
chromatin
modifications,
well
accessibility.
We
also
comment
epitranscriptomics
novel
approach
study
messenger
RNA
posttranslational
modification,
which
regulates
translation
potentially
localized
transcription
synapses
order
address
molecular
chains
that
connect
addiction
from
expression
synaptic
and,
finally,
plasticity.
American Journal of Psychiatry,
Год журнала:
2024,
Номер
181(11), С. 958 - 972
Опубликована: Окт. 9, 2024
Substance
use
disorder
(SUD)
is
common
in
psychiatric
patients
and
has
a
negative
impact
on
health
well-being.
However,
SUD
often
goes
untreated,
there
need
for
psychiatrists,
of
all
specialties,
to
address
this
pervasive
clinical
problem.
In
review,
the
authors'
goal
provide
resource
that
describes
treatments
SUD,
using
neuroscience
as
framework.
They
discuss
effect
pharmacotherapy
craving,
intoxication,
withdrawal
its
ability
interrupt
cycle
substance
SUD.
The
stress
reviewed,
including
medications
targeting
neurotransmitter
systems
activated
by
alarm
fear.
Neuroplasticity
promising
mechanism,
ketamine,
psilocybin,
transcranial
magnetic
stimulation
(TMS),
are
discussed.
authors
conclude
listing
resources
practice
guidelines
physicians
interested
learning
more
about
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 30, 2024
ABSTRACT
Proteomic
analysis
of
human
cerebral
organoids
may
reveal
how
psychedelics
regulate
biological
processes,
shedding
light
on
drug-induced
changes
in
the
brain.
This
study
elucidates
proteomic
alterations
induced
by
lysergic
acid
diethylamide
(LSD)
organoids.
By
employing
high-resolution
mass
spectrometry-based
proteomics,
we
quantitatively
analyzed
differential
abundance
proteins
exposed
to
LSD.
Our
findings
indicate
proteostasis,
energy
metabolism,
and
neuroplasticity-related
pathways.
Specifically,
LSD
exposure
led
protein
synthesis,
folding,
autophagy,
proteasomal
degradation,
suggesting
a
complex
interplay
regulation
neural
cell
function.
Additionally,
observed
modulation
glycolysis
oxidative
phosphorylation,
crucial
for
cellular
management
synaptic
In
support
data,
complementary
experiments
demonstrated
LSD’s
potential
enhance
neurite
outgrowth
vitro,
confirming
its
impact
neuroplasticity.
Collectively,
our
results
provide
comprehensive
insight
into
molecular
mechanisms
through
which
affect
neuroplasticity
potentially
contribute
therapeutic
effects
neuropsychiatric
disorders.
Proteomic
analysis
of
human
cerebral
organoids
may
reveal
how
psychedelics
regulate
biological
processes,
shedding
light
on
drug-induced
changes
in
the
brain.
This
study
elucidates
proteomic
alterations
induced
by
lysergic
acid
diethylamide
(LSD)
organoids.
By
employing
high-resolution
mass
spectrometry-based
proteomics,
we
quantitatively
analyzed
differential
abundance
proteins
exposed
to
LSD.
Our
findings
indicate
proteostasis,
energy
metabolism,
and
neuroplasticity-related
pathways.
Specifically,
LSD
exposure
led
protein
synthesis,
folding,
autophagy,
proteasomal
degradation,
suggesting
a
complex
interplay
regulation
neural
cell
function.
Additionally,
observed
modulation
glycolysis
oxidative
phosphorylation,
crucial
for
cellular
management
synaptic
In
support
data,
complementary
experiments
demonstrated
LSD's
potential
enhance
neurite
outgrowth
vitro,
confirming
its
impact
neuroplasticity.
Collectively,
our
results
provide
comprehensive
insight
into
molecular
mechanisms
through
which
affect
neuroplasticity
potentially
contribute
therapeutic
effects
neuropsychiatric
disorders.
