Possible GABAkine‐Mediated Sedative‐Like Antidepressant Effects of Phytol: Molecular Interventions Through In Vitro, In Vivo and In Silico Approaches DOI Creative Commons
Muhammad Torequl Islam, Jannatul Ferdous, Md. Sakib Al Hasan

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(3)

Опубликована: Март 1, 2025

A previous report suggests that phytol (PHY) may exert its antidepressant effects in mice, possibly through GABAA receptor interaction pathways. We aimed to check effect with possible molecular mechanisms behavioral and silico studies. For this, adult mice were randomly divided into different groups (n = 6), namely control (vehicle), standards (DZP: diazepam at 2 mg/kg, FLU: flumazenil 0.1 FLUX: fluoxetine 20 mg/kg), PHY (25, 50, 75 combined (PHY-75 DZP-2 and/or FLU-0.1, FLUX-20). Thirty minutes after treatment, each animal was subjected tail suspension forced swimming tests, their immobility time (IMT) counted for 5 min. In studies performed the α1, α2, α3, α5, γ2 subunits 5HT1A investigate mechanisms. Additionally, vitro GABA activity of reference drugs also by using colorimetric method. The results demonstrated DZP significantly (p < 0.05) concentration-dependently inhibited GABA, while FLU alone or combination reversed it. dose-dependently reduced IMT both protocols, FLUX-20 showed lower compared DZP, indicating elevated locomotion mice. It a value male animals than female animals. sexes, mg/kg increased values DZP-2, reducing this parameter FLU-0.1. exhibited higher binding affinities α2 α3 receptors -6.5, -7.2 6.7 kcal/mol, respectively. Taken together, exerted sedative-like modulated GABAergic serotonergic drug FLUX. be potential candidate management depression.

Язык: Английский

GabaAergic sedative prospection of sclareol-linalool co-treatment: An antagonistic intervention through in vivo and in silico studies DOI
Muhammad Torequl Islam, Md. Sakib Al Hasan, Jannatul Ferdous

и другие.

Neuroscience Letters, Год журнала: 2024, Номер unknown, С. 138060 - 138060

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

9

Anti-inflammatory effects of thymol: an emphasis on the molecular interactions through in vivo approach and molecular dynamic simulations DOI Creative Commons
Muhammad Torequl Islam, Mehedi Hasan Bappi, Md. Shimul Bhuia

и другие.

Frontiers in Chemistry, Год журнала: 2024, Номер 12

Опубликована: Июнь 25, 2024

Thymol (THY), as the natural monoterpene phenol, acts against oxidative stress and inflammatory processes. This study aimed to evaluate anti-inflammatory effects possible molecular mechanisms of THY via formalin-induced mouse egg albumin-induced chick models alongside docking dynamic (MD) simulations. (7.5, 15, 30 mg/kg) was investigated, compared celecoxib ketoprofen (42 mg/kg), standards. dose-dependently significantly ( p &lt; 0.05) decreased paw-licking edema diameter parameters in formalin (phases I II) models. Moreover, (15 exerted better combination with standard drug than alone celecoxib. In silico studies demonstrated elevated binding affinities cyclooxygenase-2 (COX-2) COX-1 enzyme, ligand binds at a similar location where interact. The results MD simulations confirmed stability test ligand. on Swiss mice young chicks, possibly by interacting COX-2. As conclusion, might be hopeful candidate for management disorders.

Язык: Английский

Процитировано

7

Therapeutic Efficacy Studies on the Monoterpenoid Hinokitiol in the Treatment of Different Types of Cancer DOI Creative Commons
Md. Shimul Bhuia, Raihan Chowdhury, Meher Afroz

и другие.

Chemistry & Biodiversity, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

ABSTRACT Hinokitiol (HK), a monoterpenoid that naturally occurs in plants belonging to the Cupressaceae family, possesses important biological activities, including an anticancer effect. This review summarizes its potential and draws possible molecular interventions. In addition, it evaluates biopharmaceutical, toxicological properties, clinical application of HK establish viability for future advancement as dependable medication. The assessment is based on most recent information available from various databases. Findings demonstrate substantial therapeutic advantages against diverse types cancer (colon, cervical, breast, bone, endometrial, liver, prostate, oral, skin) through mechanisms. induces oxidative stress, cytotoxicity, apoptosis, cell‐cycle arrest at G S phases, autophagy modulation phosphatidylinositol 3‐kinase (PI3K)/Akt/mammalian target rapamycin (mTOR), p38/ERK/MAPK, nuclear factor kappa B, c‐Jun N‐terminal kinase signaling pathways. Furthermore, this compound exhibits good oral bioavailability with excellent plasma clearance. Clinical uses without any significant negative effects. A thorough study pertinent data suggests may serve viable candidate developing novel therapies. Consequently, more extensive studies are necessary evaluate treatment efficacy, safety, long‐term hazards.

Язык: Английский

Процитировано

1

Modulatory Sedative Activity of Abrine on Diazepam in Thiopental Sodium Mediated Sleeping Mice: An In Vivo Approach with Receptor Binding Affinity of GABAergic Transmission DOI
Jannatul Ferdous, Md. Shimul Bhuia, Raihan Chowdhury

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(37)

Опубликована: Сен. 30, 2024

Abstract The current study aims to assess the effects of abrine (ABR) in thiopental sodium (TS)‐induced sleeping mice and explore sedative impacts compound by using vivo silico investigations. ABR (5 10 mg k −1 g, i.p.) diazepam (DZP) (2 were administered experimental animals either single or combined. TS (20 was induce sleep, latency with duration observed for 3 h. investigation conducted predict role gamma‐aminobutyric acid A (GABA ) receptor process evaluate pharmacokinetics toxicity. Results showed that (10 g) significantly ( p < 0.05) decreased period (8.20 ± 1.85 min) enhanced sleep (187.8 8.87 comparison control group. Additionally, co‐treatments DZP remarkably reduced (4.40 0.24 increased (201.40 5.89 compared therapy. molecular docking indicated has a binding affinity −7.4 kcal/mol GABA receptor. In conclusion, provides strong synergistic efficacy on TS‐induced via GABAergic system.

Язык: Английский

Процитировано

6

Assessment of sedative activity of Chrysin: Behavioral approach with pharmacokinetics, toxicological profile and molecular docking DOI
Md. Sakib Al Hasan, Md. Shimul Bhuia, Salehin Sheikh

и другие.

Sleep Medicine, Год журнала: 2024, Номер 126, С. 88 - 96

Опубликована: Дек. 8, 2024

Язык: Английский

Процитировано

5

Daidzin enhances memory and the antischizophrenia drug olanzapine's effects, possibly through the 5‐HT2A and D2 receptor interaction pathways DOI
Muhammad Torequl Islam, Raihan Chowdhury, Md. Shimul Bhuia

и другие.

Drug Development Research, Год журнала: 2024, Номер 85(6)

Опубликована: Сен. 1, 2024

Schizophrenia affects identification and disturbs our thinking motivational capacity. Long-term use of daidzin (DZN) is evident to enhance attention memory in experimental animals. This study aimed investigate the effect DZN on Swiss mice. To check animals' attention, identification, thinking, ability, we performed behavioral studies using marble burying, dust removal, trained swimming protocols. For this, a total 36 male albino mice were randomly divided into six groups, consisting 6 animals each group, as follows: control (vehicle), DZN-1.25, DZN-2.5, DZN-5 mg/kg, olanzapine (OLN)-2, combination DZN-1.25 with OLN-2. Additionally, silico are also understand possible molecular mechanisms behind this neurological effect. Findings suggest that dose-dependently significantly (p < .05) increased burying removed while reducing time reach target point. was found OLN's .05), possibly via agonizing its activity In findings has strong binding affinities -10.1 -10.4 kcal/mol against human serotonin 2 A (5-HT

Язык: Английский

Процитировано

4

Therapeutic Promises of Ferulic Acid and its Derivatives on Hepatic damage Related with Oxidative Stress and Inflammation: A Review with Mechanisms DOI
Md. Shimul Bhuia, Raihan Chowdhury, Manik Chandra Shill

и другие.

Chemistry & Biodiversity, Год журнала: 2024, Номер 21(7)

Опубликована: Май 17, 2024

Ferulic acid (FA) is a naturally occurring phenolic compound commonly found in the plant Ferula communis. This study aims to investigate hepatoprotective effect of FA and its derivatives (methyl ferulic trans-ferulic acid) against oxidative stress inflammation-related hepatotoxicity due toxicants based on results different non-clinical preclinical tests. For this, data was collected from reliable electronic databases such as PubMed, Google Scholar, ScienceDirect, etc. The this investigation demonstrated that have potent effects damage. findings also revealed these protective are antioxidant anti-inflammatory chemical compound. analogues significantly inhibit free radical generation hinder proinflammatory markers inflammatory enzymes, resulting diminished cytotoxic apoptotic hepatocyte death. compounds prevent intracellular lipid accumulation provide effects.

Язык: Английский

Процитировано

4

Anxiolytic-like effect of daidzin possibly through GABAA receptor α2 and α3 subunits interaction pathway: in vivo and in silico studies DOI
Muhammad Torequl Islam, Abdullah Al Shamsh Prottay, Md. Showkoth Akbor

и другие.

Pharmacological Research - Natural Products, Год журнала: 2024, Номер unknown, С. 100090 - 100090

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

4

Phytol exerts sedative-like effects and modulates the diazepam and flumazenil’s action, possibly through the GABAA receptor interaction pathway DOI
Muhammad Torequl Islam, Jannatul Ferdous, Md. Sakib Al Hasan

и другие.

Neuroscience Letters, Год журнала: 2024, Номер 842, С. 138007 - 138007

Опубликована: Сен. 30, 2024

Язык: Английский

Процитировано

4

Unveiling the anxiolytic and analgesic effects of citronellal in Swiss mice: in vivo and in silico insights into COX and GABAA receptor pathways DOI
Muhammad Torequl Islam, Md. Sakib Al Hasan, Raihan Chowdhury

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

Язык: Английский

Процитировано

4