CNS Neuroscience & Therapeutics,
Год журнала:
2025,
Номер
31(3)
Опубликована: Март 1, 2025
A
previous
report
suggests
that
phytol
(PHY)
may
exert
its
antidepressant
effects
in
mice,
possibly
through
GABAA
receptor
interaction
pathways.
We
aimed
to
check
effect
with
possible
molecular
mechanisms
behavioral
and
silico
studies.
For
this,
adult
mice
were
randomly
divided
into
different
groups
(n
=
6),
namely
control
(vehicle),
standards
(DZP:
diazepam
at
2
mg/kg,
FLU:
flumazenil
0.1
FLUX:
fluoxetine
20
mg/kg),
PHY
(25,
50,
75
combined
(PHY-75
DZP-2
and/or
FLU-0.1,
FLUX-20).
Thirty
minutes
after
treatment,
each
animal
was
subjected
tail
suspension
forced
swimming
tests,
their
immobility
time
(IMT)
counted
for
5
min.
In
studies
performed
the
α1,
α2,
α3,
α5,
γ2
subunits
5HT1A
investigate
mechanisms.
Additionally,
vitro
GABA
activity
of
reference
drugs
also
by
using
colorimetric
method.
The
results
demonstrated
DZP
significantly
(p
<
0.05)
concentration-dependently
inhibited
GABA,
while
FLU
alone
or
combination
reversed
it.
dose-dependently
reduced
IMT
both
protocols,
FLUX-20
showed
lower
compared
DZP,
indicating
elevated
locomotion
mice.
It
a
value
male
animals
than
female
animals.
sexes,
mg/kg
increased
values
DZP-2,
reducing
this
parameter
FLU-0.1.
exhibited
higher
binding
affinities
α2
α3
receptors
-6.5,
-7.2
6.7
kcal/mol,
respectively.
Taken
together,
exerted
sedative-like
modulated
GABAergic
serotonergic
drug
FLUX.
be
potential
candidate
management
depression.
Frontiers in Chemistry,
Год журнала:
2024,
Номер
12
Опубликована: Июнь 25, 2024
Thymol
(THY),
as
the
natural
monoterpene
phenol,
acts
against
oxidative
stress
and
inflammatory
processes.
This
study
aimed
to
evaluate
anti-inflammatory
effects
possible
molecular
mechanisms
of
THY
via
formalin-induced
mouse
egg
albumin-induced
chick
models
alongside
docking
dynamic
(MD)
simulations.
(7.5,
15,
30
mg/kg)
was
investigated,
compared
celecoxib
ketoprofen
(42
mg/kg),
standards.
dose-dependently
significantly
(
p
<
0.05)
decreased
paw-licking
edema
diameter
parameters
in
formalin
(phases
I
II)
models.
Moreover,
(15
exerted
better
combination
with
standard
drug
than
alone
celecoxib.
In
silico
studies
demonstrated
elevated
binding
affinities
cyclooxygenase-2
(COX-2)
COX-1
enzyme,
ligand
binds
at
a
similar
location
where
interact.
The
results
MD
simulations
confirmed
stability
test
ligand.
on
Swiss
mice
young
chicks,
possibly
by
interacting
COX-2.
As
conclusion,
might
be
hopeful
candidate
for
management
disorders.
Chemistry & Biodiversity,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
ABSTRACT
Hinokitiol
(HK),
a
monoterpenoid
that
naturally
occurs
in
plants
belonging
to
the
Cupressaceae
family,
possesses
important
biological
activities,
including
an
anticancer
effect.
This
review
summarizes
its
potential
and
draws
possible
molecular
interventions.
In
addition,
it
evaluates
biopharmaceutical,
toxicological
properties,
clinical
application
of
HK
establish
viability
for
future
advancement
as
dependable
medication.
The
assessment
is
based
on
most
recent
information
available
from
various
databases.
Findings
demonstrate
substantial
therapeutic
advantages
against
diverse
types
cancer
(colon,
cervical,
breast,
bone,
endometrial,
liver,
prostate,
oral,
skin)
through
mechanisms.
induces
oxidative
stress,
cytotoxicity,
apoptosis,
cell‐cycle
arrest
at
G
S
phases,
autophagy
modulation
phosphatidylinositol
3‐kinase
(PI3K)/Akt/mammalian
target
rapamycin
(mTOR),
p38/ERK/MAPK,
nuclear
factor
kappa
B,
c‐Jun
N‐terminal
kinase
signaling
pathways.
Furthermore,
this
compound
exhibits
good
oral
bioavailability
with
excellent
plasma
clearance.
Clinical
uses
without
any
significant
negative
effects.
A
thorough
study
pertinent
data
suggests
may
serve
viable
candidate
developing
novel
therapies.
Consequently,
more
extensive
studies
are
necessary
evaluate
treatment
efficacy,
safety,
long‐term
hazards.
Abstract
The
current
study
aims
to
assess
the
effects
of
abrine
(ABR)
in
thiopental
sodium
(TS)‐induced
sleeping
mice
and
explore
sedative
impacts
compound
by
using
vivo
silico
investigations.
ABR
(5
10
mg
k
−1
g,
i.p.)
diazepam
(DZP)
(2
were
administered
experimental
animals
either
single
or
combined.
TS
(20
was
induce
sleep,
latency
with
duration
observed
for
3
h.
investigation
conducted
predict
role
gamma‐aminobutyric
acid
A
(GABA
)
receptor
process
evaluate
pharmacokinetics
toxicity.
Results
showed
that
(10
g)
significantly
(
p
<
0.05)
decreased
period
(8.20
±
1.85
min)
enhanced
sleep
(187.8
8.87
comparison
control
group.
Additionally,
co‐treatments
DZP
remarkably
reduced
(4.40
0.24
increased
(201.40
5.89
compared
therapy.
molecular
docking
indicated
has
a
binding
affinity
−7.4
kcal/mol
GABA
receptor.
In
conclusion,
provides
strong
synergistic
efficacy
on
TS‐induced
via
GABAergic
system.
Drug Development Research,
Год журнала:
2024,
Номер
85(6)
Опубликована: Сен. 1, 2024
Schizophrenia
affects
identification
and
disturbs
our
thinking
motivational
capacity.
Long-term
use
of
daidzin
(DZN)
is
evident
to
enhance
attention
memory
in
experimental
animals.
This
study
aimed
investigate
the
effect
DZN
on
Swiss
mice.
To
check
animals'
attention,
identification,
thinking,
ability,
we
performed
behavioral
studies
using
marble
burying,
dust
removal,
trained
swimming
protocols.
For
this,
a
total
36
male
albino
mice
were
randomly
divided
into
six
groups,
consisting
6
animals
each
group,
as
follows:
control
(vehicle),
DZN-1.25,
DZN-2.5,
DZN-5
mg/kg,
olanzapine
(OLN)-2,
combination
DZN-1.25
with
OLN-2.
Additionally,
silico
are
also
understand
possible
molecular
mechanisms
behind
this
neurological
effect.
Findings
suggest
that
dose-dependently
significantly
(p
<
.05)
increased
burying
removed
while
reducing
time
reach
target
point.
was
found
OLN's
.05),
possibly
via
agonizing
its
activity
In
findings
has
strong
binding
affinities
-10.1
-10.4
kcal/mol
against
human
serotonin
2
A
(5-HT
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(7)
Опубликована: Май 17, 2024
Ferulic
acid
(FA)
is
a
naturally
occurring
phenolic
compound
commonly
found
in
the
plant
Ferula
communis.
This
study
aims
to
investigate
hepatoprotective
effect
of
FA
and
its
derivatives
(methyl
ferulic
trans-ferulic
acid)
against
oxidative
stress
inflammation-related
hepatotoxicity
due
toxicants
based
on
results
different
non-clinical
preclinical
tests.
For
this,
data
was
collected
from
reliable
electronic
databases
such
as
PubMed,
Google
Scholar,
ScienceDirect,
etc.
The
this
investigation
demonstrated
that
have
potent
effects
damage.
findings
also
revealed
these
protective
are
antioxidant
anti-inflammatory
chemical
compound.
analogues
significantly
inhibit
free
radical
generation
hinder
proinflammatory
markers
inflammatory
enzymes,
resulting
diminished
cytotoxic
apoptotic
hepatocyte
death.
compounds
prevent
intracellular
lipid
accumulation
provide
effects.
