Citronellal Exerts Sedative‐Like Effects and Augments Diazepam's Action in Swiss Mice, Possibly Through the GABAergic Pathway DOI Creative Commons
Muhammad Torequl Islam, Md. Sakib Al Hasan,

Emon Mia

и другие.

Brain and Behavior, Год журнала: 2025, Номер 15(3)

Опубликована: Март 1, 2025

ABSTRACT Introduction Citronellal (CTL), a monoterpenoid, exhibits notable neurological activity, including anxiolytic, and anticonvulsant effects, primarily through GABAergic pathways. Our current study aimed to explore CTL's sedative potential using in vitro, vivo, silico approaches the pathway. Methods The vitro activity of CTL was assessed via colorimetric assay, while acute toxicity evaluated Swiss mice per OECD guidelines with doses up 2000 mg/kg establish safety margins. Sedative effects were thiopental sodium (TS, 40 mg/kg)‐induced sleep protocols. administered at 62.5, 125, 250 doses, alone or combined diazepam (DZP, 2 mg/kg) flumazenil (FLU, 0.1 mg/kg). studies also performed GABA A receptors (α1 β2 subunits) investigate possible molecular mechanism. Results results demonstrated that exhibited significantly concentration‐dependent activity. Acute tests indicated high margin (no behavioral physiological abnormalities dose). Additionally, ( p < 0.05) dose‐dependently reduced latency augmented duration animals, compared control group. It decreased increased DZP‐2 reducing this parameter FLU‐0.1. In studies, binding affinities (BAs) receptor –5.6 kcal/mol. Conclusion potent strong profile interaction subunits).

Язык: Английский

Therapeutic Efficacy Studies on the Monoterpenoid Hinokitiol in the Treatment of Different Types of Cancer DOI Creative Commons
Md. Shimul Bhuia, Raihan Chowdhury, Meher Afroz

и другие.

Chemistry & Biodiversity, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

ABSTRACT Hinokitiol (HK), a monoterpenoid that naturally occurs in plants belonging to the Cupressaceae family, possesses important biological activities, including an anticancer effect. This review summarizes its potential and draws possible molecular interventions. In addition, it evaluates biopharmaceutical, toxicological properties, clinical application of HK establish viability for future advancement as dependable medication. The assessment is based on most recent information available from various databases. Findings demonstrate substantial therapeutic advantages against diverse types cancer (colon, cervical, breast, bone, endometrial, liver, prostate, oral, skin) through mechanisms. induces oxidative stress, cytotoxicity, apoptosis, cell‐cycle arrest at G S phases, autophagy modulation phosphatidylinositol 3‐kinase (PI3K)/Akt/mammalian target rapamycin (mTOR), p38/ERK/MAPK, nuclear factor kappa B, c‐Jun N‐terminal kinase signaling pathways. Furthermore, this compound exhibits good oral bioavailability with excellent plasma clearance. Clinical uses without any significant negative effects. A thorough study pertinent data suggests may serve viable candidate developing novel therapies. Consequently, more extensive studies are necessary evaluate treatment efficacy, safety, long‐term hazards.

Язык: Английский

Процитировано

1

Anxiolytic Activity of Morellic Acid: Modulation of Diazepam's Anxiolytic Effects, Possibly Through GABAergic Interventions DOI Creative Commons
Md. Shimul Bhuia,

Tanzila Akter Eity,

Raihan Chowdhury

и другие.

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(2)

Опубликована: Фев. 1, 2025

ABSTRACT Background Numerous studies suggest that morellic acid (MOR), highly available in Garcinia plants, has different physiological activities, including anti‐cancer, anti‐oxidant, and anti‐microbial activity. Aim In this investigation, we aimed to demonstrate the anxiolytic activity, along with mechanism behind activity of MOR, using vivo silico studies. Methods For this, used doses MOR (5 10 mg/kg) administered drug intraperitoneally Swiss albino mice (male female). Diazepam (DZP), a positive allosteric modulator GABA A receptor, was as control at dose 2 mg/kg (i.p), vehicle group. test, various test protocols are assess behavioral patterns mice, swing, hole cross, light–dark testing, open field testing. Results This investigation revealed remarkably reduced locomotor dose‐dependent manner produced calming behaviors like DZP. However, findings showed combination DZP synergistically locomotion compared single therapy. On other hand, from computational study, result demonstrated exhibited highest binding scores (−9.2 kcal/mol) towards receptor α3 subunit −7.6 kcal/mol α2 receptor. Whereas, −6.6 −7.3 docking affinity FLU exerted −6.2 −6.3 subunits, respectively. The ligand interacted by forming hydrogen hydrophobic bonds. Conclusion it is recommended more precise comprehensive preclinical investigations be required exact effects conduct clinical trials determine efficacy safety.

Язык: Английский

Процитировано

1

Anti-arthritic potential of linalool: in vitro, in vivo, and in silico mechanistic insights for safer therapeutic applications DOI

S U Ahammed,

Raihan Chowdhury, Md. Sakib Al Hasan

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Язык: Английский

Процитировано

1

Caffeine and sclareol take the edge off the sedative effects of linalool, possibly through the GABAA interaction pathway: molecular insights through in vivo and in silico studies DOI
Muhammad Torequl Islam, Md. Sakib Al Hasan, Jannatul Ferdous

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Язык: Английский

Процитировано

1

Unveiling the anxiolytic and analgesic effects of citronellal in Swiss mice: in vivo and in silico insights into COX and GABAA receptor pathways DOI
Muhammad Torequl Islam, Md. Sakib Al Hasan, Raihan Chowdhury

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

Язык: Английский

Процитировано

6

Daidzin enhances memory and the antischizophrenia drug olanzapine's effects, possibly through the 5‐HT2A and D2 receptor interaction pathways DOI
Muhammad Torequl Islam, Raihan Chowdhury, Md. Shimul Bhuia

и другие.

Drug Development Research, Год журнала: 2024, Номер 85(6)

Опубликована: Сен. 1, 2024

Schizophrenia affects identification and disturbs our thinking motivational capacity. Long-term use of daidzin (DZN) is evident to enhance attention memory in experimental animals. This study aimed investigate the effect DZN on Swiss mice. To check animals' attention, identification, thinking, ability, we performed behavioral studies using marble burying, dust removal, trained swimming protocols. For this, a total 36 male albino mice were randomly divided into six groups, consisting 6 animals each group, as follows: control (vehicle), DZN-1.25, DZN-2.5, DZN-5 mg/kg, olanzapine (OLN)-2, combination DZN-1.25 with OLN-2. Additionally, silico are also understand possible molecular mechanisms behind this neurological effect. Findings suggest that dose-dependently significantly (p < .05) increased burying removed while reducing time reach target point. was found OLN's .05), possibly via agonizing its activity In findings has strong binding affinities -10.1 -10.4 kcal/mol against human serotonin 2 A (5-HT

Язык: Английский

Процитировано

5

Phytol exerts sedative-like effects and modulates the diazepam and flumazenil’s action, possibly through the GABAA receptor interaction pathway DOI
Muhammad Torequl Islam, Jannatul Ferdous, Md. Sakib Al Hasan

и другие.

Neuroscience Letters, Год журнала: 2024, Номер 842, С. 138007 - 138007

Опубликована: Сен. 30, 2024

Язык: Английский

Процитировано

5

Assessment of sedative activity of Chrysin: Behavioral approach with pharmacokinetics, toxicological profile and molecular docking DOI
Md. Sakib Al Hasan, Md. Shimul Bhuia, Salehin Sheikh

и другие.

Sleep Medicine, Год журнала: 2024, Номер 126, С. 88 - 96

Опубликована: Дек. 8, 2024

Язык: Английский

Процитировано

5

Therapeutic Promises of Ferulic Acid and its Derivatives on Hepatic damage Related with Oxidative Stress and Inflammation: A Review with Mechanisms DOI
Md. Shimul Bhuia, Raihan Chowdhury, Manik Chandra Shill

и другие.

Chemistry & Biodiversity, Год журнала: 2024, Номер 21(7)

Опубликована: Май 17, 2024

Ferulic acid (FA) is a naturally occurring phenolic compound commonly found in the plant Ferula communis. This study aims to investigate hepatoprotective effect of FA and its derivatives (methyl ferulic trans-ferulic acid) against oxidative stress inflammation-related hepatotoxicity due toxicants based on results different non-clinical preclinical tests. For this, data was collected from reliable electronic databases such as PubMed, Google Scholar, ScienceDirect, etc. The this investigation demonstrated that have potent effects damage. findings also revealed these protective are antioxidant anti-inflammatory chemical compound. analogues significantly inhibit free radical generation hinder proinflammatory markers inflammatory enzymes, resulting diminished cytotoxic apoptotic hepatocyte death. compounds prevent intracellular lipid accumulation provide effects.

Язык: Английский

Процитировано

4

Anxiolytic-like effect of daidzin possibly through GABAA receptor α2 and α3 subunits interaction pathway: in vivo and in silico studies DOI
Muhammad Torequl Islam, Abdullah Al Shamsh Prottay, Md. Showkoth Akbor

и другие.

Pharmacological Research - Natural Products, Год журнала: 2024, Номер unknown, С. 100090 - 100090

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

4