Brain and Behavior,
Год журнала:
2025,
Номер
15(3)
Опубликована: Март 1, 2025
ABSTRACT
Introduction
Citronellal
(CTL),
a
monoterpenoid,
exhibits
notable
neurological
activity,
including
anxiolytic,
and
anticonvulsant
effects,
primarily
through
GABAergic
pathways.
Our
current
study
aimed
to
explore
CTL's
sedative
potential
using
in
vitro,
vivo,
silico
approaches
the
pathway.
Methods
The
vitro
activity
of
CTL
was
assessed
via
colorimetric
assay,
while
acute
toxicity
evaluated
Swiss
mice
per
OECD
guidelines
with
doses
up
2000
mg/kg
establish
safety
margins.
Sedative
effects
were
thiopental
sodium
(TS,
40
mg/kg)‐induced
sleep
protocols.
administered
at
62.5,
125,
250
doses,
alone
or
combined
diazepam
(DZP,
2
mg/kg)
flumazenil
(FLU,
0.1
mg/kg).
studies
also
performed
GABA
A
receptors
(α1
β2
subunits)
investigate
possible
molecular
mechanism.
Results
results
demonstrated
that
exhibited
significantly
concentration‐dependent
activity.
Acute
tests
indicated
high
margin
(no
behavioral
physiological
abnormalities
dose).
Additionally,
(
p
<
0.05)
dose‐dependently
reduced
latency
augmented
duration
animals,
compared
control
group.
It
decreased
increased
DZP‐2
reducing
this
parameter
FLU‐0.1.
In
studies,
binding
affinities
(BAs)
receptor
–5.6
kcal/mol.
Conclusion
potent
strong
profile
interaction
subunits).
Chemistry & Biodiversity,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
ABSTRACT
Hinokitiol
(HK),
a
monoterpenoid
that
naturally
occurs
in
plants
belonging
to
the
Cupressaceae
family,
possesses
important
biological
activities,
including
an
anticancer
effect.
This
review
summarizes
its
potential
and
draws
possible
molecular
interventions.
In
addition,
it
evaluates
biopharmaceutical,
toxicological
properties,
clinical
application
of
HK
establish
viability
for
future
advancement
as
dependable
medication.
The
assessment
is
based
on
most
recent
information
available
from
various
databases.
Findings
demonstrate
substantial
therapeutic
advantages
against
diverse
types
cancer
(colon,
cervical,
breast,
bone,
endometrial,
liver,
prostate,
oral,
skin)
through
mechanisms.
induces
oxidative
stress,
cytotoxicity,
apoptosis,
cell‐cycle
arrest
at
G
S
phases,
autophagy
modulation
phosphatidylinositol
3‐kinase
(PI3K)/Akt/mammalian
target
rapamycin
(mTOR),
p38/ERK/MAPK,
nuclear
factor
kappa
B,
c‐Jun
N‐terminal
kinase
signaling
pathways.
Furthermore,
this
compound
exhibits
good
oral
bioavailability
with
excellent
plasma
clearance.
Clinical
uses
without
any
significant
negative
effects.
A
thorough
study
pertinent
data
suggests
may
serve
viable
candidate
developing
novel
therapies.
Consequently,
more
extensive
studies
are
necessary
evaluate
treatment
efficacy,
safety,
long‐term
hazards.
CNS Neuroscience & Therapeutics,
Год журнала:
2025,
Номер
31(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Background
Numerous
studies
suggest
that
morellic
acid
(MOR),
highly
available
in
Garcinia
plants,
has
different
physiological
activities,
including
anti‐cancer,
anti‐oxidant,
and
anti‐microbial
activity.
Aim
In
this
investigation,
we
aimed
to
demonstrate
the
anxiolytic
activity,
along
with
mechanism
behind
activity
of
MOR,
using
vivo
silico
studies.
Methods
For
this,
used
doses
MOR
(5
10
mg/kg)
administered
drug
intraperitoneally
Swiss
albino
mice
(male
female).
Diazepam
(DZP),
a
positive
allosteric
modulator
GABA
A
receptor,
was
as
control
at
dose
2
mg/kg
(i.p),
vehicle
group.
test,
various
test
protocols
are
assess
behavioral
patterns
mice,
swing,
hole
cross,
light–dark
testing,
open
field
testing.
Results
This
investigation
revealed
remarkably
reduced
locomotor
dose‐dependent
manner
produced
calming
behaviors
like
DZP.
However,
findings
showed
combination
DZP
synergistically
locomotion
compared
single
therapy.
On
other
hand,
from
computational
study,
result
demonstrated
exhibited
highest
binding
scores
(−9.2
kcal/mol)
towards
receptor
α3
subunit
−7.6
kcal/mol
α2
receptor.
Whereas,
−6.6
−7.3
docking
affinity
FLU
exerted
−6.2
−6.3
subunits,
respectively.
The
ligand
interacted
by
forming
hydrogen
hydrophobic
bonds.
Conclusion
it
is
recommended
more
precise
comprehensive
preclinical
investigations
be
required
exact
effects
conduct
clinical
trials
determine
efficacy
safety.
Drug Development Research,
Год журнала:
2024,
Номер
85(6)
Опубликована: Сен. 1, 2024
Schizophrenia
affects
identification
and
disturbs
our
thinking
motivational
capacity.
Long-term
use
of
daidzin
(DZN)
is
evident
to
enhance
attention
memory
in
experimental
animals.
This
study
aimed
investigate
the
effect
DZN
on
Swiss
mice.
To
check
animals'
attention,
identification,
thinking,
ability,
we
performed
behavioral
studies
using
marble
burying,
dust
removal,
trained
swimming
protocols.
For
this,
a
total
36
male
albino
mice
were
randomly
divided
into
six
groups,
consisting
6
animals
each
group,
as
follows:
control
(vehicle),
DZN-1.25,
DZN-2.5,
DZN-5
mg/kg,
olanzapine
(OLN)-2,
combination
DZN-1.25
with
OLN-2.
Additionally,
silico
are
also
understand
possible
molecular
mechanisms
behind
this
neurological
effect.
Findings
suggest
that
dose-dependently
significantly
(p
<
.05)
increased
burying
removed
while
reducing
time
reach
target
point.
was
found
OLN's
.05),
possibly
via
agonizing
its
activity
In
findings
has
strong
binding
affinities
-10.1
-10.4
kcal/mol
against
human
serotonin
2
A
(5-HT
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(7)
Опубликована: Май 17, 2024
Ferulic
acid
(FA)
is
a
naturally
occurring
phenolic
compound
commonly
found
in
the
plant
Ferula
communis.
This
study
aims
to
investigate
hepatoprotective
effect
of
FA
and
its
derivatives
(methyl
ferulic
trans-ferulic
acid)
against
oxidative
stress
inflammation-related
hepatotoxicity
due
toxicants
based
on
results
different
non-clinical
preclinical
tests.
For
this,
data
was
collected
from
reliable
electronic
databases
such
as
PubMed,
Google
Scholar,
ScienceDirect,
etc.
The
this
investigation
demonstrated
that
have
potent
effects
damage.
findings
also
revealed
these
protective
are
antioxidant
anti-inflammatory
chemical
compound.
analogues
significantly
inhibit
free
radical
generation
hinder
proinflammatory
markers
inflammatory
enzymes,
resulting
diminished
cytotoxic
apoptotic
hepatocyte
death.
compounds
prevent
intracellular
lipid
accumulation
provide
effects.
