Journal of Ethnopharmacology, Год журнала: 2025, Номер 350, С. 120036 - 120036
Опубликована: Май 25, 2025
Язык: Английский
Chemico-Biological Interactions, Год журнала: 2025, Номер 412, С. 111459 - 111459
Опубликована: Март 5, 2025
Язык: Английский
Процитировано
1
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(42), С. 56744 - 56761
Опубликована: Окт. 11, 2024
During the process of photoaging in skin, Succinylated type I collagen has a significant effect on reversing damage caused by UVB radiation, with regulation cellular ferroptosis being one its important pathophysiological mechanisms. Specifically, reduces expression key cell cycle regulators P16, P21, and P53, as well ferroptosis-related factor Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4), induced radiation cells tissues. Meanwhile, it increases factors Glutathione Peroxidase (GPX4) Solute Carrier 7 11 (SLC7A11), which inhibit ferroptosis. Additionally, our study also reveals impact levels malondialdehyde (MDA), glutathione (GSH), reactive oxygen species (ROS) tissues, directly affecting cells' ability to cope oxidative stress. This further suggests that may improve skin through various pathways, including regulating ferroptosis, antioxidation, promoting synthesis, protecting barrier, reducing pigmentation, inhibiting inflammatory responses, contributing maintaining healthy youthful skin.
Язык: Английский
Процитировано
6
Molecular Neurobiology, Год журнала: 2024, Номер unknown
Опубликована: Авг. 7, 2024
Cognitive impairment associated with diabetes and Alzheimer's disease has become a major health issue affecting older individuals, morbidity rates growing acutely each year. Ferroptosis is novel form of cell death that triggered by iron-dependent lipid peroxidation. A body evidence suggests strong correlation between the progression cognitive diabetes, disease, ferroptosis. The pharmacological modulation ferroptosis could be promising therapeutic intervention for disease. In this review, we summarize on in context provide detailed insights into function potential action pathways Furthermore, discuss importance natural products improving new clinical treatment.
Язык: Английский
Процитировано
4
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 179, С. 117319 - 117319
Опубликована: Авг. 27, 2024
Metabolic diseases (MetD) such as diabetes mellitus, obesity, and hyperlipidemia have become global health challenges. As a naturally occurring plant component, puerarin has been verified to possess wide range of pharmacological effects including lowering blood glucose, improving insulin resistance, regulating lipid metabolism, which attracted extensive attention in recent years, its potential the treatment MetD highly acclaimed. In addition, exhibited antioxidant, anti-inflammatory, cardiovascular protective effects, are great significance prevention MetD. This article comprehensively summarizes research progress explores mechanisms, clinical applications, future perspectives. More importantly, this review provided list involved molecular mechanims treating puerarin. Taking into account these conclusions, it may provide strong foundation for optimized use patients suffering from
Язык: Английский
Процитировано
3
Chinese medicine and natural products, Год журнала: 2025, Номер 05(01), С. e23 - e29
Опубликована: Март 1, 2025
Abstract Alzheimer's disease (AD) is a neurodegenerative that affects cognitive abilities in the elderly. Puerarin plays an important role prevention and treatment of AD. It exerts potential therapeutic effects multiple aspects, including regulating expression amyloid β-protein (Aβ), inhibiting abnormal phosphorylation microtubule-associated protein-τ (Tau), scavenging free radicals, resisting oxidation, metal metabolism to maintain cholinergic system stability, improving mitochondrial dysfunction, inflammation. However, specific mechanisms by which puerarin protects cortical neurons brain are not fully explored. Hypothetical pathways still require further scientific verification.
Язык: Английский
Процитировано
0
Journal of Ethnopharmacology, Год журнала: 2025, Номер 350, С. 120036 - 120036
Опубликована: Май 25, 2025
Язык: Английский
Процитировано
0