NIR‐Assisted MgO‐Based Polydopamine Nanoparticles for Targeted Treatment of Parkinson's Disease through the Blood–Brain Barrier

Advanced Healthcare Materials, Год журнала: 2022, Номер 11(23)

Опубликована: Сен. 25, 2022

The blood-brain barrier (BBB) is a major limiting factor that prevents the treatment of Parkinson's disease (PD). In present study, MgOp@PPLP nanoparticles are explored by using MgO as substrate, polydopamine shell, wrapping anti-SNCA plasmid inside, and modifying polyethylene glycol, lactoferrin, puerarin on surface to improve hydrophilicity, brain targeting antioxidant properties particles, respectively. exhibits superior near-infrared radiation (NIR) response. Under guidance photothermal effect, these particles capable penetrating BBB be taken up neuronal cells exert gene therapy therapy. both in vivo vitro models PD, good neuroprotective effects. Therefore, combined with noninvasive NIR radiation, nanoplatform biocompatibility becomes an ideal material combat neurodegenerative diseases.

Язык: Английский

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Cytokine Storm and Neuropathological Alterations in Patients with Neurological Manifestations of COVID-19

Current Alzheimer Research, Год журнала: 2022, Номер 19(9), С. 641 - 657

Опубликована: Авг. 1, 2022

Abstract: The COVID-19 pandemic is caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2), a pathogen with neuroinvasive potential. Neurological manifestations include loss of smell and taste, headache, dizziness, stroke, potentially fatal encephalitis. Several studies found elevated proinflammatory cytokines, such as TNF-α, IFN-γ, IL-6 IL-8, IL- 10 IL-16, IL-17A, IL-18 in severely critically ill patients may persist even after apparent recovery from infection. Biomarker on CSF plasma serum have also shown high level IL-6, intrathecal IgG, neurofilament light chain (NFL), glial fibrillary acidic protein (GFAP), tau protein. Emerging evidence matter has established concept COVID-19-associated neuroinflammation, context cytokine storm. While short-term implications this condition are extensively documented, its longterm yet to be understood. association aforementioned cytokines pathogenesis neurodegenerative diseases, including Alzheimer's disease, Parkinson's Huntington's amyotrophic lateral sclerosis, increase patients' risk developing diseases. Analysis biomarkers can contribute early detection disease's exacerbation, monitoring neurological disease devising scales, identifying treatment targets.

Язык: Английский

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Drug reprofiling history and potential therapies against Parkinson’s disease

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Окт. 26, 2022

Given the high whittling down rates, costs, and moderate pace of new medication, revelation, improvement, repurposing “old” drugs to treat typical uncommon illnesses is progressively becoming an appealing proposition. Drug way toward utilizing existing medications in treating diseases other than purposes they were initially designed for. Faced with scientific economic challenges, prospect discovering medication indications enticing pharmaceutical sector. Medication can be used at various stages drug development, although it has shown most promising when previously been tested for safety. We describe strategies Parkinson’s disease, which a neurodegenerative condition that primarily affects dopaminergic neurons substantia nigra. also discuss obstacles faced by community suggest approaches solve these challenges so medicine reach its full potential.

Язык: Английский

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Influence of the Gut Microbiota on the Development of Neurodegenerative Diseases

Mediators of Inflammation, Год журнала: 2022, Номер 2022, С. 1 - 12

Опубликована: Сен. 30, 2022

Neurodegenerative disorders are marked by neuronal death over time, causing a variety of cognitive and motor dysfunctions. Protein misfolding, neuroinflammation, mitochondrial protein clearance system dysfunction have all been identified as common pathways leading to neurodegeneration in recent decades. An altered microbiome the gut, which is considered play central role diseases well health, has recently another potential feature seen neurodegenerative disorders. array microbial molecules that released digestive tract may mediate gut-brain connections permeate many organ systems, including nervous system. Furthermore, findings from clinical preclinical trials suggest microbiota gut plays critical part interplay misbalance composition be linked etiology neurological (majorly health problems); underlying mechanism still unknown. The review aims consider association between disorders, add our understanding significance mechanisms underlie it. Knowing behind microbiome’s abundance will provide us with new insights could lead novel therapeutic strategies.

Язык: Английский

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Relationship between sleep disorders and neuropsychiatric symptoms in Parkinson's disease: A narrative review

Acta Facultatis Medicae Naissensis, Год журнала: 2022, Номер 39(3), С. 259 - 274

Опубликована: Янв. 1, 2022

Aim: The objective of this narrative review was to describe the versatile links between mental status and sleep in patients with Parkinson's disease. Methods: We searched randomized controlled studies, observational meta-analyses, systematic reviews, case reports written English PubMed during 2015 - 2021. Additionally, ensure completeness review, a second, more in-depth literature search performed using same electronic database inquiries increased specificity. Results: information on pathophysiology, epidemiology, clinical features risk factors extracted formed basis for review. Despite how widespread disorders disease are, there is no about their association neuropsychiatric symptoms, such as depression, anxiety, impulse control disorders, apathy, cognitive impairment psychosis. In we described relationships these non-motor symptoms disease, timeline occurrence, gap knowledge perspectives further research. suppose that early treatment can reduce incidence extent symptoms. Conclusion: have demonstrated multiple, multidirectional However, some them remain unexplored. be applied study possibility influencing through correction different stages

Язык: Английский

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Influence of sleep quality, excessive daytime sleepiness, circadian features and motor subtypes on depressive symptoms in Parkinson’s disease

Sleep Medicine, Год журнала: 2024, Номер 125, С. 57 - 64

Опубликована: Ноя. 15, 2024

Язык: Английский

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ALEXITHYMIA IN PARKINSON'S DISEASE: A META-ANALYSIS

American Journal of Geriatric Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

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Serum Level of Brain-Derived Neurotrophic Factor and Thrombotic Type Are Predictive of Cognitive Impairment in the Acute Period of Ischemic Strokes Patients

Neurology Research International, Год журнала: 2023, Номер 2023, С. 1 - 8

Опубликована: Март 15, 2023

40-70% of patients after a stroke, including mild one, may experience cognitive impairment. Brain-derived neurotrophic factor (BDNF) plays significant role in the pathogenesis and rehabilitation ischemic stroke also affects patients' recovery prognosis. An association between impairment poststroke period lower peripheral BDNF levels is known, but prognostic significance serum clinical characteristics for risk developing acute remains uncertain. We conducted prospective cohort study phase stroke. Clinical examination, assessment neurological status, neuropsychological testing, laboratory analyzes were performed on at 1 14 days The state functions was assessed by Mini-Mental State Examination scale. Quantification blood solid-phaseenzyme-linked immunosorbent assay (ELISA). found that within an we decrease severity compared to day onset disease before start treatment level with both first 14th day. However, during 2 weeks period, no changes detected, despite general improvement condition. In our study, almost half there reduction this prevalence over weeks. low thrombotic subtype can be factors which useful planning measures.

Язык: Английский

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Clinical features of minor hallucinations in different phenotypes of Parkinson’s disease: A cross-sectional study

Frontiers in Neurology, Год журнала: 2023, Номер 14

Опубликована: Март 24, 2023

Background Minor hallucinations (MHs) are the most common psychiatric symptom associated with Parkinson’s disease (PDPsy), but little is known about their characteristics in different motor phenotypes, especially postural instability gait difficulty (PIGD). The aim of this study was to explore clinical features MHs subtypes PD. Methods In cross-sectional study, 213 patients (PD) were recruited, and data obtained included comprehensive demographics, subtypes, scale scores, MH contents. Motor classified as tremor-dominant (TD), PIGD or indeterminate according Stebbins’ method. Results A total PD included: 90 (42.3%) TD patients, 98 (46.0%) 25 (11.7%) indeterminate. total, 70 (32.9%) experienced MHs. Compared phenotype, we found that phenotype had more severe nonmotor symptoms. They also a higher incidence visual illusions (VIs) shorter latency. Conclusion Our demonstrated compared MHs, VIs, which may lead (VHs). latency than suggesting an earlier onset worse prognosis.

Язык: Английский

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COGNITIVE AND MOTOR IMPAIRMENTS IN DIFFERENT MOTOR SUBTYPES OF PARKINSON DISEASE AND PATIENTS’ QUALITY OF LIFE

Bulletin of Problems Biology and Medicine, Год журнала: 2024, Номер 1(1), С. 247 - 247

Опубликована: Янв. 1, 2024

Connection of the publication with planned research works.The article is a fragment initiative works "The role sleep disorders and circadian rhythm in diagnosis, prognosis, rehabilitation complex treatment mental diseases nervous system" (state registration number 0124U000094), "Clinical, molecular genetic neurophysiological features course various forms Parkinson's disease" 0119U102848), "Study pathogenetic clock development metabolic systemic inflammation methods aimed at these processes" 0120U101166), funded by Ministry Health Ukraine.Introduction.Among neurodegenerative diseases, disease (PD) second most common.This caused pathogenic factors, among which important are progressive loss dopaminergic neurons compact part substantia nigra oxidative stress.The classic manifestations PD rigidity, bradykinesia, tremor, postural instability.In addition to motor symptoms, some patients also experience non-motor features, such as olfactory disturbances, visual abnormalities, excessive salivation, neuropsychiatric anxiety depression [1,2].Complications levodopa treatment, dyskinesias, dystonias, fluctuations, equally for clinical evaluation.The World Organization (WHO) defines quality life "a person's perception his or her situation context culture value systems he she lives, well relation goals, expectations, standards, concerns".Quality

Язык: Английский

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