Experimental Neurology, Год журнала: 2024, Номер 385, С. 115134 - 115134
Опубликована: Дек. 29, 2024
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Май 29, 2024
Despite substantial evidence emphasizing the pleiotropic benefits of exercise for prevention and treatment various diseases, underlying biological mechanisms have not been fully elucidated. Several attributed to signaling molecules that are released in response by different tissues such as skeletal muscle, cardiac adipose, liver tissue. These molecules, which collectively termed exerkines, form a heterogenous group bioactive substances, mediating inter-organ crosstalk well structural functional tissue adaption. Numerous scientific endeavors focused on identifying characterizing new mediators with properties. Additionally, some investigations molecular targets exerkines cellular cascades trigger adaption processes. A detailed understanding tissue-specific downstream effects is crucial harness health-related mediated improve targeted programs health disease. Herein, we review current vivo exerkine-induced signal transduction across multiple target highlight preventive therapeutic value exerkine diseases. By aspects research, provide comprehensive overview (i) underpinnings secretion, (ii) receptor-dependent receptor-independent adaption, (iii) clinical implications these disease treatment.
Язык: Английский
Процитировано
12
Molecular Medicine, Год журнала: 2025, Номер 31(1)
Опубликована: Фев. 7, 2025
Abstract Engaging in activity has proven to have beneficial effects on different facets of well-being, such as conditions related the deterioration nervous system. Non-coding RNAs (ncRNAs) and exosomal ncRNAs associated with vesicles been recognized influencers gene expression cell signaling, potentially contributing positive impact physical neurodegenerative conditions. It is hypothesized that exercise-induced changes ncRNA may regulate key processes involved neuroprotection, including neuroinflammation, oxidative stress, protein aggregation, synaptic function. Exercise shown promise preventing diseases (NDs), are emerging potential mediators these benefits. In review, we explored how play a role enhancing impacts disorders for future treatments. Research studies, both preclinical clinical, documented use various exercises their treatment NDs compiled enlisted from PubMed database, spanning time period year 2000 up current time. Studies show manipulating specific or harnessing cargo could be utilized therapeutic strategies treating NDs. conclusion, studies suggest exercise modalities, aerobic, resistance, high-intensity interval training, can modulate context The altered profiles contribute neuroprotective observed interventions. However, more research needed fully understand underlying mechanisms further explore signatures biomarkers targets disorders.
Язык: Английский
Процитировано
1
Complementary Therapies in Clinical Practice, Год журнала: 2025, Номер 59, С. 101968 - 101968
Опубликована: Март 11, 2025
Язык: Английский
Процитировано
1
Translational Psychiatry, Год журнала: 2025, Номер 15(1)
Опубликована: Апрель 11, 2025
Abstract Frontotemporal dementia is a debilitating neurodegenerative disorder characterized by frontal and temporal lobe degeneration, resulting in behavioral changes, language difficulties, cognitive decline. In this study, smallRNA sequencing was conducted on postmortem brain tissues obtained from the of FTD patients with GRN , MAPT or C9ORF72 mutations. Our analysis identified miR-129-5p as consistently deregulated across all analyzed mutation conditions regions. Functional investigations in-vitro models revealed novel role astrocytes, where its loss led to neuroinflammation impaired neuronal support functions, including reduced glutamate uptake. Depletion astrocytes also resulted spines altered network activity cell culture system. These findings highlight potential therapeutic target diseases sheds light pathogenesis.
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Апрель 19, 2024
Abstract Frontotemporal dementia is a debilitating neurodegenerative disorder characterized by frontal and temporal lobe degeneration, resulting in behavioral changes, language difficulties, cognitive decline. In this study, smallRNA sequencing was conducted on postmortem brain tissues obtained from FTD patients with GRN , MAPT or C9ORF72 mutations, focusing the lobes. Our analysis identified miR-129-5p as consistently deregulated across all mutation conditions regions. Functional investigations revealed novel role of astrocytes, where its loss led to neuroinflammation impaired neuronal support functions, including reduced glutamate uptake. Depletion astrocytes resulted spines altered network activity. These findings highlight potential therapeutic target diseases also sheds light pathogenesis.
Язык: Английский
Процитировано
2
Experimental Neurology, Год журнала: 2024, Номер 385, С. 115134 - 115134
Опубликована: Дек. 29, 2024
Язык: Английский
Процитировано
0