Deciphering the Functions of Raphe–Hippocampal Serotonergic and Glutamatergic Circuits and their Deficits in Alzheimer’s Disease
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1234 - 1234
Опубликована: Янв. 30, 2025
Subcortical
innervation
of
the
hippocampus
by
raphe
nucleus
is
essential
for
emotional
and
cognitive
control.
The
two
major
afferents
from
to
originate
serotonergic
glutamatergic
neurons,
which
control
hippocampal
inhibitory
network,
theta
activity,
synaptic
plasticity
have
been
extensively
explored
in
growing
body
literature,
whereas
those
circuits
received
little
attention.
Notably,
both
between
are
disrupted
Alzheimer's
disease
(AD),
may
contribute
initiation
progression
behavioral
psychological
symptoms
dementia.
Thus,
deciphering
mechanism
underlying
abnormal
raphe-hippocampal
AD
crucial
prevent
dementia-associated
symptoms.
In
this
review,
we
summarize
anatomical,
neurochemical,
electrophysiological
diversity
nuclei
as
well
architecture
circuitry.
We
then
elucidate
subcortical
activity
their
role
regulation
emotion
cognition.
Additionally,
present
an
overview
pathogenesis
analyze
available
therapies
that
can
potentially
be
used
clinically
alleviate
neuropsychiatric
decline
course.
Язык: Английский
The interaction between neurotransmitter receptor activity and amyloid-β pathology in Alzheimer's disease
Journal of Alzheimer s Disease,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 19, 2025
The
accumulation
of
amyloid-β
(Aβ)
peptides
is
a
hallmark
Alzheimer's
disease
(AD).
Central
to
AD
pathology
the
production
Aβ
through
amyloidogenic
processing
protein
precursor
(AβPP)
by
β-secretase
(BACE-1)
and
γ-secretase.
Recent
studies
have
shifted
focus
from
plaque
deposits
more
toxic
soluble
oligomers.
One
significant
way
in
which
impair
neuronal
information
influencing
neurotransmitter
receptor
function.
These
receptors,
including
adrenergic,
acetylcholine,
dopamine,
5-HT,
glutamate,
gamma-aminobutyric
acid
(GABA)
play
crucial
role
regulating
synaptic
transmission,
underlies
perceptual
cognitive
functions.
This
review
explores
how
interacts
with
these
key
receptors
interactions
contribute
neural
dysfunction
AD.
Moreover,
we
examine
agonists
antagonists
influence
pathology,
offering
new
perspectives
on
potential
therapeutic
strategies
curb
progression
effectively
improve
patients’
quality
life.
Язык: Английский
Targeting the Serotonergic System in the Treatment of Neurodegenerative Diseases – Emerging Therapies and Unmet Challenges#
Pharmacological Reviews,
Год журнала:
2025,
Номер
unknown, С. 100071 - 100071
Опубликована: Май 1, 2025
Язык: Английский
Caveolae with serotonin and NMDA receptors as promising targets for the treatment of Alzheimer’s disease
Moeka Nakashima,
Naoko Suga,
Akari Fukumoto
и другие.
International Journal of Physiology Pathophysiology and Pharmacology,
Год журнала:
2024,
Номер
16(5), С. 96 - 110
Опубликована: Янв. 1, 2024
Alzheimer's
disease
is
the
most
general
type
of
cognitive
impairments.
Until
recently,
strategies
that
prevent
its
clinical
progression
have
remained
more
elusive.
Consequently,
research
direction
should
be
for
finding
effective
neuroprotective
agents.
It
has
been
suggested
oxidative
stress,
mitochondrial
injury,
and
inflammation
level
might
lead
to
brain
cell
death
in
many
neurological
disorders.
Therefore,
several
autophagy-targeted
bioactive
compounds
may
promising
candidate
therapeutics
prevention
damage.
Interestingly,
some
risk
genes
are
expressed
within
cells,
which
linked
cholesterol
metabolism,
lipid
transport,
endocytosis,
exocytosis
and/or
caveolae
formation,
suggesting
a
fruitful
therapeutic
target
improve
This
review
would
highlight
latest
advances
technologies
treatment
disease.
In
particular,
paradigm
serotonin
N-methyl-d-aspartate
(NMDA)
receptors
agonist/antagonist
structure
possibly
impairment.
cellular
membrane
biophysics
our
understanding
pathology
dysfunction
associated
with
Here,
this
purpose
therapy
open
potential
move
care
toward
disease-modifying
certain
benefits
patients.
Язык: Английский