Generative artificial intelligence and data augmentation for prognostic and health management: Taxonomy, progress, and prospects

Expert Systems with Applications, Год журнала: 2024, Номер 255, С. 124511 - 124511

Опубликована: Июнь 24, 2024

Язык: Английский

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Why the simplest explanation isn’t always the best

Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(52)

Опубликована: Дек. 20, 2023

Respiratory virus infections in humans are a significant global health concern, causing wide range of diseases with substantial morbidity and mortality worldwide. This underscores the urgent need for effective interventions to reduce ...Respiratory cause broad-spectrum that result annually To burden respiratory viral diseases, preventative therapeutic ...

Язык: Английский

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Editorial: Does Big Data Change Neuroscience?

Neuroscience Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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From discovery to innovation in physiological research

Experimental Physiology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 28, 2024

In 1953, Watson and Crick discovered the structure of DNA (Watson & Crick, 1953). Fifty years later, in 2003, human genome project was completed, with ∼92% sequenced (Collins et al., 2003). Between these two landmark achievements science lie numerous smaller discoveries innovations. One key events development polymerase chain reaction (PCR) technique (Saiki 1985). The basic principles were described a paper from 1971 (Kleppe 1971), but breakthrough is attributed to Kary Mullis. story goes that Mullis conceived idea using heat cycles amplify while driving one evening mountains California. His thoughts wandered, he visualized movement man-sized molecules; classic eureka moment (Mullis, 1990). However, method proved effective only after adjustments by his colleagues application Taq isolated bacterium Thermus aquaticus 1988). first identified hot springs Yellowstone National Park 1969 Thomas D. Brock (Chien 1976), naturally without knowing how much importance it would later have. Finally, increasing use PCR laboratories worldwide largely attributable commercial thermocycler. A fascinating aspect this mix discoveries, ideas innovations together form potential for groundbreaking research. polymerase, along radical, innovative PCR, milestones. Ultimately, incremental innovation thermocycler enabled large-scale analyses, culminating sequencing genome. It important recognize single or invention does not, on its own, constitute innovation. Innovation occurs when an developed implemented way fundamentally changes we do things. For example, light bulb invented 40 before Edison made relevant general use. Or consider where principal 15 applicable practical comes many forms (Table 1). Radical are well-known examples, also perspectives architectural This type not about physical architecture refers changing framework infrastructure around product concept (Henderson Clark, core aspects remain same, context transformed. value considering rely new inventions rather repurposing concepts other existing fields. example Uber. There nothing novel taxi driving, integrating into app-based service model represents significant Uber disruptive innovation, because caused massive disturbances established industry. research, could be continuous blood glucose monitoring. Although technology has existed decades, recent advances portability devices now allow field studies 24/7 data collection (Lee 2021). distinctions between different types rigid, most examples will embody characteristics multiple categories. Moreover, various terms used describe Nevertheless, recognizing traits valuable planning executing strategies, helping avoid exclusive focus challenging radical Prioritizing can drive steady progress year year. Regardless focus, crucial thinking permeates all levels organization, often involves questioning exploring paths may lead dead ends. element fostering encouraging divergent thinking, broad range possibilities, unconventional approaches looking beyond obvious. convergent essential, dynamic interplay drives ideas. Pursuing matter moments. very systematic search opportunity gaps procedures which work. Besides optimizations, found identifying pain points. Pain points typically as 'the problems, frustrations challenges customers face they interact your service'. might relate unattainable results, methods knowledge, obstacles overcome. time identify address methodically cross-disciplinary team yield surprisingly good results. prime company at SpaceX. need arises simple fact accomplish something unprecedented (something necessary yet exist), must extraordinarily innovative. goal sending hundreds Starships Mars requires mindset. To embed company, SpaceX formulated what call 'innovation algorithm', strategy designed promote optimizations accelerate (Running Algorithm: SpaceX's Approach Exponential Growth, www.youtube.com/watch?v=ZOWakxXjotg). directly parallels drawn rockets Mars. Two approach taken particularly notion rethinking constraints requirements: 'Make requirements less dumb. Challenge requirements.' Every research subject regulations, ethical guidelines specific procedural steps laboratory. essential follow rules, some stem outdated contexts, their original rationale forgotten overlooked. Re-examining sometimes reveal opportunities improvement. second principle is: 'Delete part process step', known as: 'The best no part.' Researchers aim incorporate streams analyses possible. more add, greater risk reducing efficiency errors. achieve objectives within available frame budget, eliminate unnecessary steps. Going back researchers had add enzyme each step thermosensitive destroyed cycle. That extremely consuming probably frustrating. Being able delete changed usability PCR. lies both optimizing processes achieving Looking fields outside physiological currently catalysed artificial intelligence (AI) large language models (LLMs) (Mariani 2023). AI LLMs have obvious applications communication, extracting information, writing code, etc., impressive performance warns us cautious, convenience triumph over stringency (Abdurahman 2024). uncertainty reason scepticism seen window full tool means clear. review Wang Chen (2024), cover being applied neuroscience potentially reshape landscapes extent remains uncertain, one's own spaces right blend challenges. conclusion, (or even old idea), true implementing profoundly impacts operate. foster effectively, supported leadership embedded organizational culture. cultural foundation includes willingness challenge norms accept inevitable pursuit succeed. balanced embraces than relying solely convergent, analytical thought. As industries, optimized rate generate knowledge make discoveries. Sole author. None declared. None.

Язык: Английский

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Retrieving and reconstructing conceptually similar images from fMRI with latent diffusion models and a neuro-inspired brain decoding model

Journal of Neural Engineering, Год журнала: 2024, Номер 21(4), С. 046001 - 046001

Опубликована: Июнь 17, 2024

Brain decoding is a field of computational neuroscience that aims to infer mental states or internal representations perceptual inputs from measurable brain activity. This study proposes novel approach relies on semantic and contextual similarity.

Язык: Английский

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