Temporal and Geographic Variability of International Urinary Phthalates in Humans: A Systematic Review and Meta-Analysis of Biomonitoring Data DOI Creative Commons

Jonathan M Acevedo,

Linda G. Kahn, Kristyn A. Pierce

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

Abstract Phthalates are endocrine-disrupting chemicals (EDCs) that alter hormone functions throughout the lifespan. Growing awareness of adverse health effects phthalate exposure has led to regulating certain phthalates in United States, Canada, and Europe. However, international comparisons urinary metabolite concentrations as biomarkers sparse, few studies have controlled for cohort-specific variables like pregnancy. We aimed examine trends monoester non-occupationally exposed populations globally, excluding locations where representative data already available at country level. systematically reviewed published between 2000 2023 reported concentrations. examined changes across time, controlling region, age, pregnancy status, using mixed-effects meta-regression models with without a quadratic term time. identified heterogeneity Cochran’s Q-statistic I 2 index, adjusting it trim-and-fill method. The final analytic sample consisted 216 studies. Significant differences were observed regions, age groups, pregnant non-pregnant cohorts. Our significant non-linear trend time Mono-n-butyl Mono-isononyl concentration internationally Eastern Pacific Asia (EPA). also associations Mono(2-ethyl-5-hydroxyhexyl) phthalate, Mono(2-carboxymethylhexyl) Mono(3-carboxypropyl) and/or EPA, along Mono(2-ethylhexyl) Mono-carboxy-isononyl Mono-ethyl phthalate. Additionally, showed negative linear association Latin America Africa. Heterogeneity was high, indicating potential bias our results. findings indicate need increased exposure. Further analysis attributable disease burden cost regional levels, especially low- middle-income countries, is essential understanding these other EDCs impact on population economy. Highlights Some levels significantly differed by status. Many had from 2023. MnBP MiNP increased, driven Most metabolites’ declined overall region-specific over There insufficient many regions.

Язык: Английский

The Autism Spectrum Disorder and Its Possible Origins in Pregnancy DOI Open Access
Rayane Martins Botelho, Ana Lúcia M. Silva, Alexandre Urban Borbely

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2024, Номер 21(3), С. 244 - 244

Опубликована: Фев. 20, 2024

Autism Spectrum Disorder (ASD) belongs to the group of neurodevelopmental disorders, and has a high prevalence, affecting 1 in 100 children according data from World Health Organization (WHO). To be diagnosed with ASD, child must have persistent deficits communication social interactions, restricted repetitive patterns behavior, interests, or activities. Despite its etiology ASD is still uncertain, multifactorial characteristics, including those associated gestational period, where maternal exposure biological, chemical, physical hazards occurs, some which already been proposed as causes outcomes. Since pregnancy requires balance between maternal–fetal binomial, breakdown this caused by such environmental can lead altered fetal neurodevelopment, ASD. With firmly mind, review aims compile most recent on that may development help health professionals identify risk factors act for prevention management

Язык: Английский

Процитировано

8
Modulation effects of folic acid and vitamin D on the relationships between prenatal cumulative phthalate exposure and preschoolers’ emotional and behavioral problems DOI Creative Commons
L Chen, Xin Chen, Han Chen

и другие.

Environment International, Год журнала: 2025, Номер 196, С. 109284 - 109284

Опубликована: Янв. 22, 2025

The results of current population-based studies exploring the effects prenatal phthalate exposure on children's behavioral problems are not completely consistent. In addition, it is clear whether vitamins improve phthalate-induced health risks. This study was based Ma'anshan Birth Cohort, which included 2910 mother-child pairs. To assess behavior, we used Strengths and Difficulties Questionnaire (SDQ). A latent category growth model to scores each subscale SDQ. Quantile g-computation Bayesian kernel machine regression were applied analyze effect cumulative exposure. Prenatal associated with "borderline abnormal emotional symptoms" trajectory (β = 0.146, 95 % CI -0.0003, 0.292), affecting girls more in areas, boys conduct areas. There an interaction between folic acid supplementation, vitamin D levels mixtures risk behavior children, reflected mainly prosocial problems. increased symptoms there sex differences. duration supplementation level can affect emotion behavior.

Язык: Английский

Процитировано

0
Heavy metals and phthalate contamination in prenatal vitamins and folic acid supplements DOI
Hannah Gardener,

Jaclyn Bowen,

Sean P. Callan

и другие.

Environmental Research, Год журнала: 2025, Номер unknown, С. 121255 - 121255

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Beyond Infections: Exploring Immune-Mediated Pathways Linking Cannabis and Emerging Environmental Contaminants to Neurodevelopmental Outcomes DOI

T. L. Doolittle,

Natalia Duque‐Wilckens

Advances in experimental medicine and biology, Год журнала: 2025, Номер unknown, С. 281 - 309

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Association between prenatal phthalate exposure and ano-genital indices among offsprings in an Israeli cohort DOI Creative Commons
Itai Gueta, J. Megan Ross,

Revital Sheinberg

и другие.

Heliyon, Год журнала: 2024, Номер 10(13), С. e33633 - e33633

Опубликована: Июнь 25, 2024

BackgroundIn-utero phthalate exposure was shown to be associated with shortened anogenital distance (AGD) in male newborns, but findings among female are inconsistent. While pregnant women Israel is widespread, no study has examined the association offspring AGD. The objective of current investigate between maternal phthalates urinary concentration and AGD at time delivery a birth cohort Israel.MethodsWe measured spot monobutyl (MBP), monobenzyl (MBzP), mono-2-ethyl-5-carboxypentyl (MECPP), mono-2-ethyl-5-hydroxyhexylphthalate (MEHHP), mono-2-ethyl-5-oxohexyl (MEOHP) presenting room Shamir Medical Center Israel. Birthweight, length were all newborns using standardized protocol. Each measurement adjusted weight (ano-genital index). Confounders included socio-demographic characteristics, comorbidities obstetrical history. Univariate multivariate analyses assessed associations phthalates, confounders AGD.ResultsOverall, 193 mother infant analyzed. All born term had normal Apgar scores. Mean age 32 ±4.7 years old. pregnancy week 3183 ±498 grams 39 ±1.3, respectively. Median (IQR) creatinine (ug/g) 3.96 (2.2-6.6), 1.22 (0.7-2), 10.84 (7-20.4), 6.36 (3.3-11.2) 0.64 (0.4-1.1) for MBP, MBzP, MECPP, MEHHP MEOHP, comparison showed significant higher than median MBzP concentration, Ano-Fourchetal index (AFI: 4.4 vs. 4.1, p=0.037) Ano-clitoral (ACI: 11.5 10.4, p=0.032) infants. Total ≥ 26.25 ug/g significantly smaller penile width (3.5 3.7, p=0.022), ACI (11.6 10.3, p=0.013) trend towards significance AFI (4.3 p=0.055). Following linear regression only PWI remained total concentration.ConclusionsMaternal not AGD, inversely width.

Язык: Английский

Процитировано

1
Associations between Urinary Phthalate Metabolites with BDNF and Behavioral Function among European Children from Five HBM4EU Aligned Studies DOI Creative Commons
Elena Salamanca‐Fernández, Lydia Espín-Moreno, Alicia Olivas-Martínez

и другие.

Toxics, Год журнала: 2024, Номер 12(9), С. 642 - 642

Опубликована: Авг. 31, 2024

Based on toxicological evidence, children’s exposure to phthalates may contribute altered neurodevelopment and abnormal regulation of brain-derived neurotrophic factor (BDNF). We analyzed data from five aligned studies the Human Biomonitoring for Europe (HBM4EU) project. Ten phthalate metabolites protein BDNF levels were measured in urine samples 1148 children aged 6–12 years Italy (NACII-IT cohort), Slovakia (PCB-SK Hungary (InAirQ-HU cohort) Norway (NEBII-NO). Serum was also available 124 Slovenian (CRP-SLO cohort). Children’s total, externalizing internalizing behavioral problems assessed using Child Behavior Checklist at 7 age (only NACII-IT Adjusted linear negative binomial regression models fitted, together with weighted quantile sum (WQS) assess mixture associations. Results showed that, boys but not girls cohort, each natural-log-unit increase mono-n-butyl (MnBP) Mono(2-ethyl-5-oxohexyl) (MEOHP) cross-sectionally associated higher [incidence rate ratio (IRR): 1.20; 95% CI: 1.02, 1.42 1.26; 1.03, 1.55, respectively]. A suggestive association observed per tertile whole population (WQS—IRR = 1.15; 0.97, 1.36) (IRR 0.96, 1.49). In NACII-IT, PCB-SK, InAirQ-HU NEBII-NO cohorts together, urinary strongly levels, WQS confirming a (percent change (PC) 25.9%; 17.6, 34.7), (PC 18.6%; 7.92, 30.5) mainly among 36.0%; 24.3, 48.9). Among CRP-SLO boys, ∑DINCH concentration lower serum (PC: −8.8%; −16.7, −0.3). predicted worse scores all (IRR: 1.00, 1.32). suggest that (1) di-n-butyl (DnBP) di(2-ethylhexyl) (DEHP) is more (2) DINCH associate systemic (3) concentrations (although caution needed since possibility “urine bias” could explain these associations noncausal terms identified) (4) predict problems. Given this first study examine relationship between metabolite biomarkers, future are validate

Язык: Английский

Процитировано

1
Natural products modulate phthalate-associated miRNAs and targets DOI Creative Commons

Ya-Ting Chuang,

Ching‐Yu Yen,

Tsu‐Ming Chien

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 284, С. 117015 - 117015

Опубликована: Сен. 11, 2024

Язык: Английский

Процитировано

1
Oxidative stress as a potential mechanism linking gestational phthalates exposure to cognitive development in infancy DOI

Kaegan Ortlund,

Susan L. Schantz,

Andréa Aguiar

и другие.

Neurotoxicology and Teratology, Год журнала: 2024, Номер 106, С. 107397 - 107397

Опубликована: Окт. 2, 2024

Язык: Английский

Процитировано

1
Temporal and Geographic Variability of International Urinary Phthalates in Humans: A Systematic Review and Meta-Analysis of Biomonitoring Data DOI Creative Commons

Jonathan M Acevedo,

Linda G. Kahn, Kristyn A. Pierce

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 11, 2024

Abstract Phthalates are endocrine-disrupting chemicals (EDCs) that alter hormone functions throughout the lifespan. Growing awareness of adverse health effects phthalate exposure has led to regulating certain phthalates in United States, Canada, and Europe. However, international comparisons urinary metabolite concentrations as biomarkers sparse, few studies have controlled for cohort-specific variables like pregnancy. We aimed examine trends monoester non-occupationally exposed populations globally, excluding locations where representative data already available at country level. systematically reviewed published between 2000 2023 reported concentrations. examined changes across time, controlling region, age, pregnancy status, using mixed-effects meta-regression models with without a quadratic term time. identified heterogeneity Cochran’s Q-statistic I 2 index, adjusting it trim-and-fill method. The final analytic sample consisted 216 studies. Significant differences were observed regions, age groups, pregnant non-pregnant cohorts. Our significant non-linear trend time Mono-n-butyl Mono-isononyl concentration internationally Eastern Pacific Asia (EPA). also associations Mono(2-ethyl-5-hydroxyhexyl) phthalate, Mono(2-carboxymethylhexyl) Mono(3-carboxypropyl) and/or EPA, along Mono(2-ethylhexyl) Mono-carboxy-isononyl Mono-ethyl phthalate. Additionally, showed negative linear association Latin America Africa. Heterogeneity was high, indicating potential bias our results. findings indicate need increased exposure. Further analysis attributable disease burden cost regional levels, especially low- middle-income countries, is essential understanding these other EDCs impact on population economy. Highlights Some levels significantly differed by status. Many had from 2023. MnBP MiNP increased, driven Most metabolites’ declined overall region-specific over There insufficient many regions.

Язык: Английский

Процитировано

0