Biochemical Journal, Год журнала: 2025, Номер 482(11), С. 721 - 739
Опубликована: Май 28, 2025
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor symptoms including tremor, rigidity, and bradykinesia as well degeneration of dopamine (DA) neurons in the substantia nigra pars compacta (SNc). A minority PD cases are familial caused single genetic mutation. One most common PD-causing genes leucine-rich repeat kinase 2 (LRRK2), which causes an autosomal dominant that presents very similarly to sporadic PD. Pathogenic mutations LRRK2 increase its activity, indicated both autophosphorylation phosphorylation substrates. To date, mechanism(s) elevated activity induces DA neuron has not been fully elucidated. potential mechanism may involve role on mitochondria, mitochondrial dysfunction linked pathogenesis, exciting recent evidence connected pathogenic multiple aspects associated with disease. In this review, we discuss current knowledge implicating energetics, oxidative stress, genome integrity, fission/fusion, mitophagy, ion/protein transport PD, examine play mediating effects therapeutics being investigated for treatment
Язык: Английский