Birch Sap Preserves Memory Function in Rats by Enhancing Cerebral Blood Flow and Modulating the Presynaptic Glutamatergic System in the Hippocampus DOI Open Access

Chaochao Huang,

Tzu‐Kang Lin,

Chia-Chuan Chang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5009 - 5009

Опубликована: Май 22, 2025

As the average age of population increases, memory impairment has become an increasingly prevalent issue. This study investigates effects 14 days oral birch sap administration on functions in healthy rats using Morris water maze (MWM) test and explores underlying mechanisms. A compositional analysis revealed that soap is rich polysaccharides, specifically a low-molecular weight polysaccharide (MW 1.29 kDa), exhibits no hepatotoxicity or renal toxicity at tested dose. The results from MWM demonstrated time distance required to reach platform were significantly shorter sap-treated group compared control group, suggesting supports preservation. Moreover, treated with showed improved cerebral blood flow rats. Additionally, hippocampal nerve terminals (synaptosomes), exhibited significant increase evoked glutamate release, as well elevated levels presynaptic proteins, including vesicular transporter 1 (VGluT1), synaptophysin, synaptobrevin, synaptotagmin, syntaxin, synapsin I, 25 kDa synaptosome-associated protein (SNAP-25). Transmission electron microscopy also notable number synaptic vesicles synaptosomes birch-sap-treated These findings suggest enhances glutamatergic flow, contributing its memory-preserving

Язык: Английский

Ketogenic Diet-Induced Alterations in Neuronal Signaling-Related Proteins are Not Due to Differences in Synaptosome Protein Levels DOI Creative Commons

Rachel Fletcher,

Meagan Hoppe,

Joseph A. McQuail

и другие.

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

Язык: Английский

Процитировано

0
Birch Sap Preserves Memory Function in Rats by Enhancing Cerebral Blood Flow and Modulating the Presynaptic Glutamatergic System in the Hippocampus DOI Open Access

Chaochao Huang,

Tzu‐Kang Lin,

Chia-Chuan Chang

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5009 - 5009

Опубликована: Май 22, 2025

As the average age of population increases, memory impairment has become an increasingly prevalent issue. This study investigates effects 14 days oral birch sap administration on functions in healthy rats using Morris water maze (MWM) test and explores underlying mechanisms. A compositional analysis revealed that soap is rich polysaccharides, specifically a low-molecular weight polysaccharide (MW 1.29 kDa), exhibits no hepatotoxicity or renal toxicity at tested dose. The results from MWM demonstrated time distance required to reach platform were significantly shorter sap-treated group compared control group, suggesting supports preservation. Moreover, treated with showed improved cerebral blood flow rats. Additionally, hippocampal nerve terminals (synaptosomes), exhibited significant increase evoked glutamate release, as well elevated levels presynaptic proteins, including vesicular transporter 1 (VGluT1), synaptophysin, synaptobrevin, synaptotagmin, syntaxin, synapsin I, 25 kDa synaptosome-associated protein (SNAP-25). Transmission electron microscopy also notable number synaptic vesicles synaptosomes birch-sap-treated These findings suggest enhances glutamatergic flow, contributing its memory-preserving

Язык: Английский

Процитировано

0