Medicina,
Год журнала:
2025,
Номер
61(3), С. 547 - 547
Опубликована: Март 20, 2025
Alzheimer’s
disease
(AD),
the
most
prevalent
form
of
dementia,
is
marked
by
progressive
cognitive
decline,
affecting
memory,
language,
orientation,
and
behavior.
Pathological
hallmarks
include
extracellular
amyloid
plaques
intracellular
tau
tangles,
which
disrupt
synaptic
function
connectivity.
Neural
oscillations,
rhythmic
synchronization
neuronal
activity
across
frequency
bands,
are
integral
to
processes
but
become
dysregulated
in
AD,
contributing
network
dysfunction
memory
impairments.
Targeting
these
oscillations
has
emerged
as
a
promising
therapeutic
strategy.
Preclinical
studies
have
demonstrated
that
specific
modulations
can
restore
oscillatory
balance,
improve
plasticity,
reduce
pathology.
In
animal
models,
interventions,
such
gamma
entrainment
using
sensory
stimulation
transcranial
alternating
current
(tACS),
shown
efficacy
enhancing
modulating
neuroinflammatory
responses.
Clinical
trials
reported
improvements
with
repetitive
magnetic
(rTMS)
deep
brain
(DBS),
particularly
when
targeting
key
hubs
memory-related
networks,
default
mode
(DMN)
frontal–parietal
network.
Moreover,
gamma-tACS
been
linked
increased
cholinergic
enhanced
connectivity,
correlated
improved
outcomes
AD
patients.
Despite
advancements,
challenges
remain
optimizing
parameters,
individualizing
treatment
protocols,
understanding
long-term
effects.
Emerging
approaches,
including
pulse
(TPS)
closed-loop
adaptive
neuromodulation,
hold
promise
for
refining
strategies.
Integrating
neuromodulation
pharmacological
lifestyle
interventions
may
maximize
benefits.
Continued
interdisciplinary
efforts
essential
refine
approaches
translate
them
into
clinical
practice,
advancing
potential
neural
oscillation-based
therapies
AD.
NeuroImage,
Год журнала:
2024,
Номер
289, С. 120550 - 120550
Опубликована: Фев. 20, 2024
Visual
crowding
is
the
difficulty
in
identifying
an
object
when
surrounded
by
neighbouring
flankers,
representing
a
bottleneck
for
perception.
Crowding
arises
not
only
from
activity
of
visual
areas
but
also
parietal
and
fronto-parietal
network
activity.
Parietal
would
provide
dorsal-to-ventral
guidance
identification
modulate
attentional
resolution.
Several
studies
highlighted
relevance
beta
oscillations
(15-25
Hz)
these
other
connatural
phenomena.
In
present
study,
we
investigated
differential
contribution
cortex
resolution
crowding.
During
task
with
letter
stimuli,
high-definition
transcranial
Alternating
Current
Stimulation
(tACS)
band
(18
was
delivered
bilaterally
on
sites,
right
network,
sham
regime.
Resting-state
EEG
recorded
before
after
stimulation
to
measure
tACS-induced
aftereffects.
The
influence
reduced
tACS
sites.
this
condition,
power
stimulation.
Furthermore,
magnitude
aftereffects
varied
as
function
individual
differences
oscillations.
Results
corroborate
link
between
crowding,
providing
fundamental
insights
brain
rhythms
underlying
perception
suggesting
that
can
induce
plastic
changes
areas.
Remarkably,
findings
open
new
possibilities
neuromodulatory
interventions
disorders
characterised
abnormal
such
dyslexia.
Integrative Psychological and Behavioral Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 20, 2024
Abstract
The
concept
of
free
will
has
challenged
physicists,
biologists,
philosophers,
and
other
professionals
for
decades.
constrained
disorder
principle
(CDP)
is
a
fundamental
law
that
defines
systems
according
to
their
inherent
variability.
It
provides
mechanisms
adapting
dynamic
environments.
This
work
examines
the
CDP's
perspective
concerning
various
theories.
Per
CDP,
lack
intentions,
"freedom"
select
act
built
into
design.
embedded
within
response
range
determined
by
boundaries
systems'
built-in
self-generating
mechanism
enables
cope
with
perturbations.
According
neither
dualism
nor
an
unknown
metaphysical
apparatus
dictates
choices.
Brain
variability
facilitates
cognitive
adaptation
complex,
unpredictable
situations
across
Human
behaviors
decisions
reflect
underlying
physical
in
brain
organs
dealing
noises.
Choices
are
not
predetermined
but
ongoing
processes
prssu½res.
Malfunctions
disease
states
characterized
inappropriate
variability,
reflecting
inability
respond
adequately
Incorporating
CDP-based
interventions
can
overcome
malfunctions
improve
decision
processes.
second-generation
artificial
intelligence
platforms
being
evaluated
augment
personal
development,
wellness,
health.
Scientific Reports,
Год журнала:
2023,
Номер
13(1)
Опубликована: Авг. 18, 2023
Abstract
A
normative
electrographic
activity
map
could
be
a
powerful
resource
to
understand
normal
brain
function
and
identify
abnormal
activity.
Here,
we
present
using
scalp
EEG
in
terms
of
relative
band
power.
In
this
exploratory
study
investigate
its
temporal
stability,
similarity
other
imaging
modalities,
explore
potential
clinical
application.
We
constructed
maps
dynamics
from
17
healthy
controls
source-localised
resting-state
recordings.
then
correlated
these
with
those
acquired
MEG
intracranial
their
similarity.
Lastly,
use
the
lateralise
regions
epilepsy.
Spatial
patterns
powers
were
broadly
consistent
previous
literature
stable
across
Scalp
most
similar
modalities
alpha
band,
relatively
bands.
Towards
application
epilepsy,
found
ipsilateral
epileptogenic
hemisphere.
power
are
spatially
time,
keeping
results.
Normative
mapping
is
feasible
may
potentially
clinically
useful
Future
studies
larger
sample
sizes
high-density
now
required
for
validation.
NeuroImage,
Год журнала:
2023,
Номер
284, С. 120424 - 120424
Опубликована: Окт. 30, 2023
Magnetoencephalography
and
electroencephalography
(M/EEG)
seed-based
connectivity
analysis
requires
the
extraction
of
measures
from
regions
interest
(ROI).
M/EEG
ROI-derived
source
activity
can
be
treated
in
different
ways.
It
is
possible,
for
instance,
to
average
each
ROI's
time
series
prior
calculating
measures.
Alternatively,
one
compute
maps
element
ROI
dimensionality
reduction
obtain
a
single
map.
The
impact
these
strategies
on
results
still
unclear.
Here,
we
address
this
question
within
large
MEG
resting
state
cohort
(N=113)
simulated
data.
We
consider
68
ROIs
(Desikan-Kiliany
atlas),
two
(phase
locking
value-PLV,
its
imaginary
counterpart-
ciPLV),
three
frequency
bands
(theta
4-8
Hz,
alpha
9-12
beta
15-30
Hz).
compare
four
methods:
(i)
mean,
or
(ii)
PCA
seed
before
computing
connectivity,
map
(iii)
average,
(iv)
maximum
after
seed.
Hierarchical
clustering
then
applied
outputs
across
multiple
strategies,
followed
by
direct
contrasts
methods.
Finally,
are
validated
using
set
realistic
simulations.
show
that
ROI-based
vary
remarkably
terms
magnitude
spatial
distribution.
Dimensionality
procedures
conducted
more
similar
each-other,
while
approach
most
dissimilar
other
approaches.
Although
differences
methods
consistent
bands,
they
influenced
metric
size.
Greater
were
observed
ciPLV
than
PLV,
larger
ROIs.
Realistic
simulations
confirmed
aggregation
generally
accurate
but
have
lower
specificity
(higher
rate
false
positive
connections).
Though
computationally
demanding,
should
preferred
when
higher
sensitivity
desired.
Given
remarkable
procedures,
caution
warranted
comparing
studies
applying
Brain Communications,
Год журнала:
2024,
Номер
6(4)
Опубликована: Янв. 1, 2024
Abstract
Electrophysiologic
disturbances
due
to
neurodegenerative
disorders
such
as
Alzheimer’s
disease
and
Lewy
Body
are
detectable
by
scalp
EEG
can
serve
a
functional
measure
of
severity.
Traditional
quantitative
methods
analysis
often
require
an
a-priori
selection
clinically
meaningful
features
susceptible
bias,
limiting
the
clinical
utility
routine
EEGs
in
diagnosis
management
disorders.
We
present
data-driven
tensor
decomposition
approach
extract
top
6
spectral
spatial
representing
commonly
known
sources
activity
during
eyes-closed
wakefulness.
As
part
their
neurologic
evaluation
at
Mayo
Clinic,
11
001
patients
underwent
12
176
routine,
standard
10–20
studies.
From
these
raw
EEGs,
we
developed
algorithm
based
on
posterior
alpha
eye
movement
automatically
select
awake-eyes-closed
epochs
estimated
average
power
density
(SPD)
between
1
45
Hz
for
each
channel.
then
created
three-dimensional
(3D)
(record
×
channel
frequency)
applied
canonical
polyadic
six
factors.
further
identified
independent
cohort
meeting
consensus
criteria
mild
cognitive
impairment
(30)
or
dementia
(39)
with
Bodies
(31)
similarly
aged
cognitively
normal
controls
(36).
evaluated
ability
factors
differentiating
subgroups
using
Naïve
Bayes
classification
assessed
linear
associations
factor
loadings
Kokmen
short
test
mental
status
scores,
fluorodeoxyglucose
(FDG)
PET
uptake
ratios
CSF
Disease
biomarker
measures.
Factors
represented
biologically
brain
activities
including
rhythm,
anterior
delta/theta
rhythms
centroparietal
beta,
which
correlated
patient
age
dysrhythmia
grade.
These
were
also
able
distinguish
from
moderate
high
degree
accuracy
(Area
Under
Curve
(AUC)
0.59–0.91)
(AUC
0.61).
Furthermore,
relevant
performance,
metabolism
AB42
measures
subgroup.
This
study
demonstrates
that
approaches
population-level
without
artefact
rejection
channels
frequency
bands.
With
continued
development,
may
improve
memory
care
assisting
early
identification
different
causes
impairment.
Neurophysiologie Clinique,
Год журнала:
2025,
Номер
55(3), С. 103056 - 103056
Опубликована: Янв. 30, 2025
The
activity
profile
of
the
posterior
insula
in
neuropathic
pain
(NeP)
remains
largely
unexplored.
To
address
this
and
examine
its
modulation
by
somatosensory
stimulation,
we
recorded
local
field
potentials
(LFP)
awake
patients
with
NeP
undergoing
deep
brain
stimulation
(DBS)
electrode
implantation
to
posterior-superior
(PSI)
for
analgesic
purposes.
Six
(one
woman;
32-45
years),
experiencing
refractory
peripheral
having
previously
responded
non-invasive
PSI
underwent
stereotactic
DBS
electrodes
as
part
a
phase
II
clinical
trial.
averaged
power
frequencies
LFP
their
peaks
were
calculated
during
rest
under
thermal
painful
mechanical
non-painful
stimulation.
At
rest,
amplitude
within
delta
(average
min-max.:
2.2
Hz;
1.3-3.7)
theta
(6.1
Hz,
varying
between
5.7
6.8
Hz)
bands
identified.
Compared
both
tonic
painful,
led
similar
mean
decreases
gamma
(-24.46
±
70.56,
-19.56
3.08;
respectively).
Painful
stimuli
caused
an
increase
all
other
frequency
bands,
mainly
alpha
beta
ranges,
while
above
4Hz.
was
associated
significantly
greater
variability,
frequency,
compared
nonpainful
resting
state
chronic
characterized
predominant
oscillations.
innocuous
opposite
spectral
changes,
much
larger
variability
across
whole
spectrum
stimuli,
relative