Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Год журнала: 2022, Номер 7(9), С. 849 - 851
Опубликована: Сен. 1, 2022
Язык: Английский
Trends in Cognitive Sciences, Год журнала: 2023, Номер 27(5), С. 433 - 445
Опубликована: Фев. 3, 2023
Язык: Английский
Процитировано
47
Biological Psychiatry, Год журнала: 2024, Номер 96(1), С. 57 - 66
Опубликована: Янв. 6, 2024
Background Serotonergic psychedelics, such as psilocybin, alter perceptual and cognitive systems that are functionally integrated with the amygdala. These changes can cognition emotions hypothesised to contribute their therapeutic utility. However, neural mechanisms of subcortical altered by psychedelics not well understood. Methods We used functional MRI resting state images collected during a randomised, double-blinded, placebo-controlled clinical trial 24 healthy adults under 0.2mg/kg psilocybin estimate directed (i.e., effective) between amygdala three large-scale resting-state networks involved in cognition. default mode network (DMN), salience (SN), central executive (CEN). Results found pattern decreased top-down effective connectivity from these Effective within DMN SN however increased CEN. were statistically associated behavioural measures emotion influence psilocybin. Conclusions Our findings suggest temporary signal attenuation is mechanistic RSN connectivity. significant for perception suggests targets research investigating efficacy psychedelic therapy internalising psychiatric disorders. More broadly, our study value quantifying brain's hierarchical organisation using identify important basic function how they give rise subjective experiences.
Язык: Английский
Процитировано
13
Frontiers in Psychiatry, Год журнала: 2024, Номер 15
Опубликована: Май 14, 2024
Intense interest surrounds current research on psychedelics, particularly regarding their potential in treating mental health disorders. Various studies suggest a link between the subjective effects produced by psychedelics and therapeutic efficacy. Neuroimaging evidence indicates an association of changes brain functional connectivity with psychedelics. We conducted review focusing connectivity. The focused four psychedelic drugs: ayahuasca, psilocybin LSD, entactogen MDMA. searches databases MEDLINE, Embase, APA PsycInfo Scopus from inception to Jun 2023 keywords related Using PRISMA framework, we selected 24 articles initial pool 492 for analysis. This scoping analysis investigated experiences healthy individuals. quantified through psychometric scales, revealing significant altered consciousness, mood elevation, mystical induced results indicated alterations consistent findings across substances decreased within default mode network increased sensory thalamocortical Correlations these neurophysiological were noted, suggesting basis psychedelics' neuropsychological impact. While result provides neural mechanism direct clinical is needed advance outcomes. Our serves as foundation further exploration
Язык: Английский
Процитировано
8
Human Brain Mapping, Год журнала: 2025, Номер 46(5)
Опубликована: Апрель 1, 2025
ABSTRACT Lysergic acid diethylamide (LSD) is a classic serotonergic psychedelic that induces profoundly altered conscious state. In conjunction with psychological support, it currently being explored as treatment for generalized anxiety disorder and depression. The dorsolateral prefrontal cortex (DLPFC) brain region known to be involved in mood regulation disorders; hypofunction the left DLPFC associated This study investigated role of psycho‐emotional effects LSD functional magnetic resonance imaging (fMRI) magnetoencephalography (MEG) data healthy human participants during acute experience. fMRI data, we measured correlation between changes resting‐state connectivity (RSFC) post‐scan subjective ratings positive mood, emotional arousal, ego dissolution. We found significant, correlations dissolution & right DLPFC, thalamus, higher‐order visual area, fusiform face area (FFA). Additionally, arousal was significantly increased intraparietal sulcus (IPS), salience network (SN). A confirmational “reverse” analysis, which outputs original RSFC analysis were used input seeds, substantiated aforementioned regions both arousal. Subsequently, on directed MEG source‐localized output reverse analyses. Granger causality (GC) revealed information flow two nodes ‘ego network’, thalamus theta band, substantiating hypothesis disruptions thalamic gating underlie experience Overall, this multimodal elucidates LSD‐induced states consciousness sheds more light basis
Язык: Английский
Процитировано
1
Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Год журнала: 2023, Номер 9(5), С. 522 - 532
Опубликована: Июль 31, 2023
While the exploration of serotonergic psychedelics as psychiatric medicines deepens, so does pressure to better understand how these compounds act on brain. We used a double-blind, placebo-controlled, crossover design and administered lysergic acid diethylamide (LSD), 3,4-methylenedioxymethamphetamine (MDMA), d-amphetamine in 25 healthy participants. By employing spectral dynamic causal modeling, we mapped substance-induced changes effective-connectivity between thalamus different cortex types (unimodal vs. transmodal) derived from previous study resting-state functional magnetic resonance imaging (fMRI) data. Due distinct pharmacological modes action three substances, were able investigate specific effects mainly driven by neurotransmitter systems thalamocortical corticothalamic interactions. Compared placebo, all substances increased unimodal cortices, whereas influence cortices was reduced. These results indicate bottom-up decreased top-down information flow some cortices. However, for amphetamines, found opposite when examining with transmodal covering parts salience network. Intriguingly, LSD both indicating breach hierarchical organization ongoing brain activity. Results advance our knowledge concerning refine current models aiming explain underlying neurobiological processes.
Язык: Английский
Процитировано
9
Psychoactives, Год журнала: 2024, Номер 3(1), С. 93 - 122
Опубликована: Фев. 26, 2024
The human brain is an extraordinarily complex organ responsible for all aspects of cognition and control. Billions neurons form connections with thousands other neurons, resulting in trillions synapses that create a vast intricate network. This network subjected to continuous remodeling adapts environmental developmental changes. neuroplasticity crucial both healthy states many forms mental illness neurodegeneration. narrative review comprehensively examines N,N-dimethyltryptamine (DMT), naturally occurring hallucinogen psychedelic compound, focusing on its implications promoting via neuritogenesis. We examine DMT’s pharmacology, including interaction serotonergic, sigma-1, trace amine-associated receptors their associated signaling pathways. therapeutic potential DMT animal models clinical trials discussed impacts perception, cognition, emotion, consciousness. uniquely focus current directions centered unveiling the direct mechanisms effects demonstrate transformative well-being, particularly conditions like depression, anxiety, post-traumatic stress disorder. discuss connection between neuroplasticity, offering forming new neural connections, improving learning, memory, aiding recovery from injuries, neurorehabilitation neuroregeneration. ultimate efficacy enhance neurogenesis, especially neurodegenerative conditions, also discussed.
Язык: Английский
Процитировано
3
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Апрель 28, 2024
Abstract Psychedelics are serotonergic drugs that profoundly alter consciousness, yet their neural mechanisms not fully understood. A popular theory, RElaxed Beliefs Under pSychedelics (REBUS), posits psychedelics flatten the hierarchy of information flow in brain. Here, we investigate based on imbalance between sending and receiving brain signals, as determined by directed functional connectivity. We measure a magnetoencephalography (MEG) dataset 16 healthy human participants who were administered psychedelic dose (75 micrograms, intravenous) lysergic acid diethylamide (LSD) under four different conditions. LSD diminishes asymmetry connectivity when averaged across time. Additionally, demonstrate machine learning classifiers distinguish placebo more accurately trained one our metrics than traditional measures Taken together, these results indicate weakens increasing balance senders receivers signals.
Язык: Английский
Процитировано
3
NeuroImage, Год журнала: 2025, Номер unknown, С. 121242 - 121242
Опубликована: Апрель 1, 2025
Modafinil promotes wakefulness and enhances cognitive function through mechanisms neural effects that are still partially unknown. Several studies have shown the compound alters functional cortical architecture. In contrast, its influence on subcortical regions thalamocortical connections, which crucial for modulating neocortical connectivity, remains unexplored. The acute modulation of thalamo-cortical connectivity was assessed in two groups participants who received either a single 100 mg dose modafinil (N=25) or placebo (N=25). Magnetic Resonance Imaging (MRI) used to parcel thalamus into constituent nuclei, served as seeds voxel-wise resting state analyses. Additionally, maps nuclei-specific reorganization were compared those receptor/transporter expression assess their spatial overlaps. Modafinil, but not placebo, altered three thalamic nuclei. Specifically, medial pulvinar nuclei showed increased with Sensorimotor Salience/Ventral Attention (SVAN) Networks. These changes spatially overlapped distribution norepinephrine transporter (NET). anterior inferior complex exhibited enhanced insular supramarginal SVAN superior frontal area Default Mode Network (DMN). However, unlike pulvinar, these linked any specific receptor transporter. Finally, ventrolateral posterior region DMN FrontoParietal Network, along decreased premotor cortex. topography modifications mainly overlaps glutamatergic serotonergic receptors. summary, our findings highlight modafinil's circuits, emphasizing role higher-order complex.
Язык: Английский
Процитировано
0
Опубликована: Май 21, 2025
Abstract The pulvinar, the largest nucleus in human thalamus, is a complex, highly interconnected structure. Through dense, organized network of cortical and subcortical areas, it provides adequate cooperation between neural systems, which crucial for multiple high-order functions such as perception, visuospatial attention, emotional processing. Such central role made possible by precise internal topographical organization, mirrored anatomical connections well expression neurochemical markers. While being traditionally subdivided into sub-nuclei, each characterized distinct connectional morphological features, recent studies both primate brains have highlighted that this organization only marginally aligns with conventional histological subdivision. Instead, has been delineated context continuous gradients along dorsoventral mediolateral axes. multi-gradient extensively documented models, remains relatively underexplored brain. present work combines high-quality, multi-modal structural functional imaging data recently published whole-brain, large-scale, positron emission tomography (PET) atlas detailing 19 neurotransmitters receptors distributed across By applying diffusion embedding analysis to tractography, connectivity, receptor coexpression data, we identify characterize topographically connections, coactivation, molecular binding patterns. We demonstrate converge on shared representation axes pulvinar. This transitions spanning from lower-level higher-order regions. Moreover, paralleled gradual changes markers associated key neuromodulator including serotoninergic, noradrenergic, dopaminergic, opioid systems. Our findings represent significant step forward understanding pulvinar anatomy function, offering an exploratory framework investigate structure health disease.
Язык: Английский
Процитировано
0
Neuroscience & Biobehavioral Reviews, Год журнала: 2025, Номер unknown, С. 106239 - 106239
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0