Brain compensatory activation during Stroop task in patients with mild cognitive impairment: a functional near-infrared spectroscopy study

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Фев. 7, 2025

This study investigated the disparities in brain activation patterns during Stroop task among individuals with mild cognitive impairment (MCI) and those without any impairments (healthy controls, HCs) using functional near-infrared spectroscopy (fNIRS). We analyzed cortical of 73 patients MCI 63 HC as they completed task, employing fNIRS. The regions interest (ROIs) included dorsal prefrontal cortex (dPFC), ventrolateral (VLPFC), parietal lobe (PL). is divided into early stage (0-15 s) late (15-30 s). also measured participants' behavior variations intensity at different experiment stages, performed correlation analysis between Montreal Cognitive Assessment (MoCA) scores, performance, oxygenation levels. Our revealed that demonstrated elevated dPFC, VLPFC, PL areas while performing (q < 0.05, FDR-corrected). group displayed longer response latencies compared to demonstrating comparable accuracy performance across both congruent incongruent trials. showed compensatory Correlational a negative association MoCA scores levels (p 0.05). However, no was found behavioral performance. Mild effective compensation for their partial level by engaging prefrontal, task.

Язык: Английский

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iVR-fNIRS: studying brain functions in a fully immersive virtual environment

Neurophotonics, Год журнала: 2024, Номер 11(02)

Опубликована: Апрель 4, 2024

Immersive virtual reality (iVR) employs head-mounted displays or cave-like environments to create a sensory-rich experience that simulates the physical presence of user in digital space. The technology holds immense promise neuroscience research and therapy. In particular, (VR) technologies facilitate development diverse tasks scenarios closely mirroring real-life situations stimulate brain within controlled secure setting. It also offers cost-effective solution providing similar sense interaction users when conventional stimulation methods are limited unfeasible. Although combining iVR with traditional imaging techniques may be difficult due signal interference instrumental issues, recent work has proposed use functional near infrared spectroscopy (fNIRS) conjunction for versatile paradigms flexible examination responses. We present comprehensive review current studies employing an iVR-fNIRS setup, covering device types, approaches, data analysis methods, major scientific findings. literature demonstrates high potential explore various types cognitive, behavioral, motor functions fully immersive VR environment. Such should set foundation adaptive programs both training (e.g., novel environments) clinical therapeutics pain, sensory disorders other psychiatric conditions).

Язык: Английский

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Possible influence of sex on the relationship between dual-task gait costs and cognitive decline in older adults

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0317365 - e0317365

Опубликована: Янв. 30, 2025

The impact of cognitive decline in older adults can be evaluated with dual-task gait (DTG) testing which a task is performed during walking, leading to increased costs gait. Previous research demonstrated that higher DTG correlate increasing deficits and age. present study was conducted explore whether the relationship between abilities individuals influenced by sex differences. To address this objective, we 216 elderly participants (age range: 60 75 years, 127 females). These underwent Cognitive Functional Dementia (CFD) determine their evaluate parameters (gait speed, cadence, stride length, variance, stance phase duration) while performing backward serial number counting task. We carried out correlation analysis CFD scores costs. were calculated as percentage difference single- testing, effects compared considering factors A significant negative found only males. did not differ sexes, women obtained superior test. significantly correlated age men. In summary, our provides evidence that, unlike women, increase men, correlating declines performance findings suggest assessment DT characteristics relation may manifest differently sexes.

Язык: Английский

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Effects of visual impairment and its restoration on electroencephalogram during walking in aged females

Chinese Medical Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Abstract Background: Visual input significantly influences cerebral activity related to locomotor navigation, although the underlying mechanism remains unclear. This study aimed analyze effects of chronic visual impairment and its rehabilitation on sensorimotor integration during level walking in patients with age-related cataract. Methods: prospective case series enrolled 14 female (68.4 ± 4.7 years) cataract, scheduled for consecutive cataract surgeries at Department Ophthalmology Peking University Third Hospital from June 2019 2020. Electroencephalogram (EEG) signals were recorded using a portable EEG system before 4 weeks after restoration. Walking speed was assessed Footscan system. Spectral power theta alpha bands analyzed repeated-measures analysis variance, Assignment (rest walking), Phase (preoperative postoperative), Electrode sites (F3, Fz, F4, O1, O2) as within-subject factors. Results: Compared state, band decreased restoration (13.16 1.58 μV 2 vs. 23.65 3.48 , P = 0.018). Theta notably reduced (17.24 2.43 37.86 6.62 0.017), while rest not statistically significant difference between two phases (9.44 1.24 9.08 1.74 0.864). Changes correlated alterations O1 ( r −0.574, 0.032) O2 −0.648, 0.012) rest. Alpha remained stable unaffected by status. Conclusions: Chronic triggers enhanced activation compensate decline locomotion. over-activation is effectively alleviated

Язык: Английский

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Advancing Gait Analysis: Integrating Multimodal Neuroimaging and Extended Reality Technologies

Bioengineering, Год журнала: 2025, Номер 12(3), С. 313 - 313

Опубликована: Март 19, 2025

The analysis of human gait is a cornerstone in diagnosing and monitoring variety neuromuscular orthopedic conditions. Recent technological advancements have paved the way for innovative methodologies that combine multimodal neuroimaging eXtended Reality (XR) technologies to enhance precision applicability analysis. This review explores state-of-the-art solutions an advanced approach, multidisciplinary concept integrates neuroimaging, extended reality technologies, sensor-based methods study locomotion. Several wearable modalities such as functional near-infrared spectroscopy (fNIRS) electroencephalography (EEG), commonly used monitor analyze brain activity during walking explore neural mechanisms underlying motor control, balance, adaptation, were considered. XR including virtual, augmented, mixed reality, enable creation immersive environments analysis, real-time simulation, movement visualization, facilitating comprehensive assessment locomotion its biomechanical dynamics. approach enhances understanding by examining both cerebral aspects, offering insights into brain–musculoskeletal coordination. We highlight potential provide real-time, high-resolution data improved clinical decision-making rehabilitation strategies. Additionally, we address challenges integrating these fusion, computational demands, scalability. concludes proposing future research directions leverage artificial intelligence further optimize imaging applications ultimately driving their translation from laboratory settings practice. synthesis underscores transformative approaches personalized medicine patient outcomes.

Язык: Английский

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Synchronization of Neurophysiological and Biomechanical Data in a Real-Time Virtual Gait Analysis System (GRAIL): A Proof-of-Principle Study

Sensors, Год журнала: 2024, Номер 24(12), С. 3779 - 3779

Опубликована: Июнь 11, 2024

The investigation of gait and its neuronal correlates under more ecologically valid conditions as well real-time feedback visualization is becoming increasingly important in neuro-motor rehabilitation research. Gait Real-time Analysis Interactive Lab (GRAIL) offers advanced opportunities for gait-related research by creating naturalistic yet controlled environments through immersive virtual reality. Investigating the aspects requires parallel recording brain activity, such mobile electroencephalography (EEG) and/or functional near-infrared spectroscopy (fNIRS), which must be synchronized with kinetic /or kinematic data recorded while walking. This proof-of-concept study outlines required setup use lab streaming layer (LSL) ecosystem real-time, simultaneous collection two independently operating multi-channel EEG fNIRS measurement devices kinetics. In this context, a customized approach using photodiode to synchronize systems described. demonstrates achievable temporal accuracy synchronous acquisition neurophysiological GRAIL. By event-related cerebral hemodynamic activity visually evoked potentials during start-to-go task checkerboard test, we were able confirm that our system can replicate known physiological phenomena latencies millisecond range relate each other sufficient accuracy.

Язык: Английский

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Regional brain activity and neural network changes in cognitive-motor dual-task interference: A functional near-infrared spectroscopy study

NeuroImage, Год журнала: 2024, Номер 297, С. 120714 - 120714

Опубликована: Июнь 29, 2024

Previous neuroimaging studies have reported dual-task interference (DTi) and deterioration of task performance in a cognitive-motor dual (DT) compared to that single (ST). Greater frontoparietal activity is neural signature DTi; nonetheless, the underlying mechanism cortical network DTi still remains unclear. This study aimed investigate regional brain changes during induced by highly demanding DT. Thirty-four right-handed healthy young adults performed spiral-drawing task. They underwent paced auditory serial addition test (PASAT) simultaneously or independently while their was measured using functional near-infrared spectroscopy. Motor determined balanced integration score (BIS), index drawing speed precision. The cognitive PASAT administered with two difficulty levels defined 1 s (PASAT-1 s) 2 (PASAT-2 intervals, allowing for numbers. Cognitive percentage correct responses. These motor performances were significantly reduced DT, which combined at either level, those corresponding ST conditions. DT conditions also characterized increased right dorsolateral prefrontal cortex (DLPFC) Multivariate Granger causality (GC) analysis selected regions interest further revealed selective top-down causal connectivity from DLPFC inferior parietal DTs. Furthermore, GC strength between PASAT-2 correlated negatively Therefore, can occur even cognitively proficient adults, being crucial mechanisms DTi. findings provide new insights into its implications clinical utility DTs applied populations decline, such as psychiatric disorders.

Язык: Английский

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Brain Activation During Motor Preparation and Execution in Patients with Mild Cognitive Impairment: An fNIRS Study

Brain Sciences, Год журнала: 2025, Номер 15(4), С. 333 - 333

Опубликована: Март 23, 2025

Objectives: This study aimed to investigate how motor preparation impacted brain activation in individuals with differing cognitive statuses. Methods: We investigated the cortical pattern of 57 mild impairment (MCI) and 67 healthy controls (HCs) using functional near-infrared spectroscopy (fNIRS) during prepared walking (PW) single (SW) tasks. The focused on assessing activity four regions interest (ROIs): prefrontal cortex (PFC), primary cortex, secondary parietal lobe. Additionally, we examined behavioral performance-gait speed-during tasks, analyzed variations intensity, conducted correlation analyses between Montreal Cognitive Assessment (MoCA) scores, gait speed, oxygenation levels. Results: There was no significant difference speed patients MCI HCs. group exhibited lower compared HCs execution stage PW (q < 0.05, FDR-corrected). (r = 0.23, p 0.02) cortices 0.19, 0.04) correlated significantly MoCA scores. Furthermore, PFC 0.22, 0.02), 0.01), 0.20, lobe 0.03) positively speed. Conclusions: Our results revealed that preparing for tasks modulated neural patterns without affecting their performance.

Язык: Английский

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Cortical activation of neuromuscular electrical stimulation synchronized mirror neuron rehabilitation strategies: an fNIRS study

Frontiers in Neurology, Год журнала: 2023, Номер 14

Опубликована: Авг. 4, 2023

The mirror neuron system (MNS) plays a key role in the neural mechanism underlying motor learning and plasticity. Action observation (AO), action execution (AE), combination of both, known as imitation (AI), are most commonly used rehabilitation strategies based on MNS. It is possible to enhance cortical activation area amplitude by combining traditional neuromuscular electrical stimulation (NMES) with other top-down active MNS theory.

Язык: Английский

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The prefrontal cortex hemodynamic responses to dual-task paradigms in older adults: A systematic review and meta-analysis

Heliyon, Год журнала: 2023, Номер 9(7), С. e17812 - e17812

Опубликована: Июль 1, 2023

BackgroundFunctional near-infrared spectroscopy (fNIRS) is a method to measure cerebral hemodynamics. Determining the changes in prefrontal cortex (PFC) hemodynamics during dual-task paradigms essential explaining alterations physical activities, especially older adults.AimsTo systematically review and meta-analyze effects of on PFC adults.MethodsThe search was conducted PubMed, Scopus, Web Science from inception until March 2023 identify studies The meta-analysis included variables hemodynamics, such as oxygenated hemoglobin (HbO2) deoxygenated (HbR). heterogeneity determined using I2 statistic. Additionally, subgroup analysis compare different types cognitive tasks.ResultsA total 37 were systematic review, 25 comprising 2224 adults meta-analysis. Our findings showed that inhibitory control working memory tasks significantly increased HbO2 by 0.53 (p < 0.01, 95% CI = 0.37 0.70) 0.13 0.08 0.18) μmol/L, respectively. Overall, 0.36 μmol/L (P 0.27 0.45). Moreover, also decreased HbR 0.04 −0.07 −0.01). Specifically, −0.13 −0.02), but did not change tasks.ConclusionCognitive related required greater demands, indicating higher pfc activation adults. for clinical implications, increase decrease may help explain why are more likely fall daily activities.

Язык: Английский

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