Brain Function Characteristics of Children with Attention-Deficit/Hyperactivity Disorder Aged 4-9 Years During a GO/NOGO Task: An Functional Near-Infrared Spectroscopy Study DOI Creative Commons
Zhijun Cui,

Aimin Liang,

Hongmei Huang

и другие.

Neuropsychiatric Disease and Treatment, Год журнала: 2024, Номер Volume 20, С. 2507 - 2516

Опубликована: Дек. 1, 2024

Purpose: This study investigated whether abnormal cerebral activity observed in adolescents and adults with ADHD also occurs children during the early developmental stages of executive function. Methods:The included 52 aged 4.0-9.0years 34 healthy control children.Changes oxygenated hemoglobin (HbO) levels were measured while participants completed GO/NOGO tasks to assess brain activation connectivity.Results: Children demonstrated a stable prefrontal deficit (p FDR < 0.05).Additionally, hyperconnectivity was between motor area lobe these (uncorrected p <0.01).The logistic regression model incorporating connectivity features achieved an under ROC curve 0.86 (95% CI, [0.78, 0.95]), sensitivity 0.79 specificity 0.85. Conclusion:The findings suggest that region abnormalities are present at stages.This underscores importance targeting cortex interventions highlights role multi-network coordination ADHD-related abnormalities.Limitations include cross-sectional design relatively small sample size, which should be addressed future longitudinal studies.

Язык: Английский

Brain Function Characteristics of Children with Attention-Deficit/Hyperactivity Disorder Aged 4-9 Years During a GO/NOGO Task: An Functional Near-Infrared Spectroscopy Study DOI Creative Commons
Zhijun Cui,

Aimin Liang,

Hongmei Huang

и другие.

Neuropsychiatric Disease and Treatment, Год журнала: 2024, Номер Volume 20, С. 2507 - 2516

Опубликована: Дек. 1, 2024

Purpose: This study investigated whether abnormal cerebral activity observed in adolescents and adults with ADHD also occurs children during the early developmental stages of executive function. Methods:The included 52 aged 4.0-9.0years 34 healthy control children.Changes oxygenated hemoglobin (HbO) levels were measured while participants completed GO/NOGO tasks to assess brain activation connectivity.Results: Children demonstrated a stable prefrontal deficit (p FDR < 0.05).Additionally, hyperconnectivity was between motor area lobe these (uncorrected p <0.01).The logistic regression model incorporating connectivity features achieved an under ROC curve 0.86 (95% CI, [0.78, 0.95]), sensitivity 0.79 specificity 0.85. Conclusion:The findings suggest that region abnormalities are present at stages.This underscores importance targeting cortex interventions highlights role multi-network coordination ADHD-related abnormalities.Limitations include cross-sectional design relatively small sample size, which should be addressed future longitudinal studies.

Язык: Английский

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