Journal of Neuro-Oncology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 16, 2025
Язык: Английский
NeuroImage, Год журнала: 2024, Номер 289, С. 120547 - 120547
Опубликована: Фев. 18, 2024
Parkinson's disease (PD) is a common neurodegenerative disease, and apart from few rare genetic causes, its pathogenesis remains largely unclear. Recent scientific interest has been captured by the involvement of iron biochemistry disruption homeostasis, particularly within brain regions specifically affected in PD. The advent Quantitative Susceptibility Mapping (QSM) enabled non-invasive quantification vivo MRI, which contributed to understanding iron-associated potential for development iron-based biomarkers This review elucidates biochemical underpinnings accumulation, details advancements iron-sensitive MRI technologies, discusses role QSM as biomarker deposition Despite considerable progress, several challenges impede clinical application after decade studies. initiation multi-site research warranted developing robust, interpretable, disease-specific monitoring PD progression.
Язык: Английский
Процитировано
22
Environmental Pollution, Год журнала: 2024, Номер 348, С. 123732 - 123732
Опубликована: Март 8, 2024
The gut-brain axis is a crucial interface between the central nervous system and gut microbiota. Recent evidence shows that exposure to environmental contaminants, such as heavy metals, can cause dysbiosis in microbiota, which may affect communication, impacting aspects of brain function behavior. This systematic review literature aims evaluate whether deleterious effects on due metal could be mediated by changes microbiota profile. Animal studies involving metals comparison with control group evaluated neuropsychological outcomes and/or molecular along analysis composition were reviewed. authors independently assessed for inclusion, extracted data risk bias using protocol Systematic Review Center Laboratory Experimentation (SYRCLE) preclinical studies. A search 3 databases yielded 16 eligible focused lead (n = 10), cadmium 1), mercury 3), manganese combined Pb Mn 1). animal species rats 7), mice 4), zebrafish carp 1) fruit fly Heavy found adversely cognitive function, behavior, neuronal morphology. Moreover, was associated abundance specific bacterial phyla, Firmicutes Proteobacteria, play roles health. In some studies, these alterations correlated learning memory impairments mood disorders. interplay suggests induce direct indirect through contributing neurotoxicity development However, small number papers under makes it difficult draw definitive conclusions. Further research warranted unravel underlying mechanisms translational implications human
Язык: Английский
Процитировано
18
Annals of Medicine, Год журнала: 2025, Номер 57(1)
Опубликована: Март 4, 2025
It is now understood that iron crosses the blood-brain barrier via a complex metabolic regulatory network and participates in diverse critical biological processes within central nervous system, including oxygen transport, energy metabolism, synthesis catabolism of myelin neurotransmitters. During brain development, distributed throughout brain, playing pivotal role key such as neuronal myelination, neurotransmitter synthesis. In physiological aging, can selectively accumulate specific regions, impacting cognitive function leading to intracellular redox imbalance, mitochondrial dysfunction, lipid peroxidation, thereby accelerating aging associated pathologies. Furthermore, accumulation may be primary contributor neurodegenerative diseases Alzheimer's Parkinson's diseases. Comprehending diseases, utilizing iron-sensitive Magnetic Resonance Imaging (MRI) technology for timely detection or prediction abnormal neurological states, implementing appropriate interventions instrumental preserving normal system function.
Язык: Английский
Процитировано
3
Frontiers in Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Фев. 26, 2024
Introduction Alzheimer’s disease (AD), characterized by distinctive pathologies such as amyloid-β plaques and tau tangles, also involves deregulation of iron homeostasis, which may accelerate neurodegeneration. This meta-analysis evaluated the use quantitative susceptibility mapping (QSM) to detect accumulation in deep gray matter (DGM) basal ganglia AD, contributing a better understanding AD progression, potentially leading new diagnostic therapeutic approaches. Methods Using Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines, we systematically searched PubMed, Scopus, Web Sciences, Google Scholar databases up October 2023 studies employing QSM research. Eligibility criteria were based on PECO framework, included assessing alterations magnetic indicative DGM patients with AD. After initial screening quality assessment using Newcastle-Ottawa Scale, was conducted compare levels between healthy controls (HCs) random-effects model. Results The nine comprising 267 272 HCs. There significantly higher values, indicating greater deposition, putamen (standardized mean difference (SMD) = 1.23; 95% CI: 0.62 1.84; p 0.00), globus pallidus (SMD 0.79; 0.07 1.52; 0.03), caudate nucleus 0.72; 0.39 1.06; 0.00) compared However, no significant differences found thalamus 1.00; −0.42 2.43; 0.17). sensitivity analysis indicated that single study impacted overall results. Age identified major contributor heterogeneity across all nuclei subgroup analysis. Older age (>69 years) lower male percentage (≤30%) associated increase Conclusion suggests excessive deposition is linked especially putamen. underscores complex nature pathology iron, influenced age, sex, regional differences, necessitating further research comprehensive understanding.
Язык: Английский
Процитировано
13
Heliyon, Год журнала: 2024, Номер 10(7), С. e27950 - e27950
Опубликована: Март 26, 2024
Magnetic resonance imaging (MRI) techniques, such as quantitative susceptibility mapping (QSM) and susceptibility-weighted (SWI), can detect iron deposition in the brain. Iron accumulation putamen (PUT) contribute to pathogenesis of Parkinson's disease (PD) atypical Parkinsonian disorders. This systematic review aimed synthesize evidence on PUT assessed by MRI techniques PD Parkinsonism syndromes. The PubMed Scopus databases were searched for relevant studies. Thirty-four studies from January 2007 October 2023 that used QSM, SWI, or other methods measure putaminal PD, progressive supranuclear palsy (PSP), multiple system atrophy (MSA), healthy controls (HCs) included. Most have found increased levels patients versus HCs based higher susceptibility. Putaminal correlates with worse motor scores cognitive decline PD. Evidence regarding differences between is emerging, several showing greater PSP MSA than patients. Alterations help distinguish these disorders Increased appear be associated severity progression. Thus, magnetic abnormal Parkinsonism. Moreover, quantifying may serve an biomarker monitor changes aid differential diagnosis
Язык: Английский
Процитировано
12
Brain, Год журнала: 2024, Номер 147(11), С. 3665 - 3680
Опубликована: Июль 22, 2024
Abstract The interaction between ageing and multiple sclerosis is complex carries significant implications for patient care. Managing effectively requires an understanding of how impact brain structure function. Ageing inherently induces changes, including reduced plasticity, diminished grey matter volume, ischaemic lesion accumulation. When combined with pathology, these age-related alterations may worsen clinical disability. also influence the response patients to therapies and/or their side effects, highlighting importance adjusted treatment considerations. MRI highly sensitive age- sclerosis-related processes. Accordingly, can provide insights into relationship sclerosis, enabling a better pathophysiological interplay informing selection. This review summarizes current knowledge on immunopathological aspects in CNS context sclerosis. Starting from immunosenescence, ageing-related pathological mechanisms specific features like enlarged Virchow-Robin spaces, this then explores aspects, late-onset age diagnostic criteria, comorbidity effects imaging features. role neurodegeneration, iron dynamics myelin changes influenced by contribute defining patients, are discussed.
Язык: Английский
Процитировано
11
Neurobiology of Aging, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Cerebral Cortex, Год журнала: 2025, Номер 35(3)
Опубликована: Март 1, 2025
Abstract Evidence has linked head trauma to increased risk factors for neuropathology, including mechanical deformation of the sulcal fundus and, later, perivascular accumulation hyperphosphorylated tau adjacent these spaces related chronic traumatic encephalopathy. However, little is known about microstructural abnormalities and cellular dyshomeostasis in acute mild brain injury humans, particularly cortex. To address this gap, we designed first architectonically motivated quantitative susceptibility mapping study assess regional patterns net positive (iron-related) negative (myelin-, calcium-, protein-related) magnetic across 34 cortical regions interest following injury. Bilateral, between-group analyses sensitive depth curvature were conducted between 25 males with (<14 d) sports-related age-matched male controls. Results suggest a trauma-induced increase focal superficial, perivascular-adjacent parahippocampal sulcus. Decreases values distinct voxel populations within same region indicate potential dual pathology neural substrates. These injury–related from age-related processes revealed by correlation analyses. Our findings depth- curvature-specific deposition biological substrates tissue convergent features misfolded proteins trauma-related neurodegeneration.
Язык: Английский
Процитировано
1
Human Brain Mapping, Год журнала: 2025, Номер 46(6)
Опубликована: Апрель 15, 2025
ABSTRACT Quantitative susceptibility mapping (QSM) is an advanced MRI technique for assessing iron, calcium, and myelin tissue levels based on magnetic susceptibility. QSM consists of multiple processing steps, with various choices each step. While increasingly applied in neurodegenerative disease research, its reproducibility sensitivity detecting changes across groups or over time, which underpin the interpretation clinical outcomes, have not been thoroughly quantified. This study aimed to evaluate how background field removal (BFR), dipole inversion algorithms, anatomical referencing impact detection deep gray matter We used aging‐related brain established earlier foundational studies, as a surrogate model test 378 different pipelines toward longitudinal setting. 10‐year follow‐up data scan‐rescan healthy adults scanned at 3T. Our results demonstrated high variability changes. most detected same over‐time changes, choice BFR algorithm strategy influenced error substantially. Notably, using RESHARP AMP‐PE, HEIDI, LSQR showed highest overall sensitivity. The findings suggest strong algorithmic ability detect physiological brain. Careful consideration should be given pipeline configuration reliable outcomes.
Язык: Английский
Процитировано
1
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Год журнала: 2024, Номер unknown, С. 1 - 12
Опубликована: Июль 3, 2024
: Previous studies have suggested a link between dysregulation of cortical iron levels and neuronal loss in amyotrophic lateral sclerosis (ALS) patients. However, few reported differences quantitative susceptibility mapping (QSM) values subcortical nuclei patients with ALS healthy controls (HCs).
Язык: Английский
Процитировано
8