bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 1, 2024
Abstract
Aging
affects
brain
structure
and
function
alongside
metabolic
vascular
processes
leading
to
energetic
impairments.
While
local
neurometabolic
dysfunction
in
aging
is
well-documented,
the
influence
of
systemic
cardiometabolic
markers
on
remains
less
understood.
We
examine
link
between
(measured
by
an
allostatic
load
index)
neurovascular
burden
white
matter
hyperintensities)
with
changes,
including
ventricular
hippocampal
volume,
as
well
EEG
activity,
across
age.
Analyzing
data
from
196
healthy
individuals
age
(20-75
years),
we
found
a
significant
positive
correlation
index
white-matter
hyperintensities,
irrespective
White-matter
hyperintensities
are
also
positively
linked
enlargement,
but
not
atrophy.
The
mediated
relationship
volume.
Regarding
function,
changes
spectral
aperiodic
exponent
periodic
alpha
power
were
index.
Such
hyperintensities.
Thus,
findings
suggest
that
state,
measured
index,
plays
crucial
role
health
age,
particularly
influencing
enlargement
increased
activity.
Nature Medicine,
Год журнала:
2024,
Номер
30(12), С. 3646 - 3657
Опубликована: Авг. 26, 2024
Abstract
Brain
clocks,
which
quantify
discrepancies
between
brain
age
and
chronological
age,
hold
promise
for
understanding
health
disease.
However,
the
impact
of
diversity
(including
geographical,
socioeconomic,
sociodemographic,
sex
neurodegeneration)
on
brain-age
gap
is
unknown.
We
analyzed
datasets
from
5,306
participants
across
15
countries
(7
Latin
American
Caribbean
(LAC)
8
non-LAC
countries).
Based
higher-order
interactions,
we
developed
a
deep
learning
architecture
functional
magnetic
resonance
imaging
(2,953)
electroencephalography
(2,353).
The
comprised
healthy
controls
individuals
with
mild
cognitive
impairment,
Alzheimer
disease
behavioral
variant
frontotemporal
dementia.
LAC
models
evidenced
older
ages
(functional
imaging:
mean
directional
error
=
5.60,
root
square
(r.m.s.e.)
11.91;
electroencephalography:
5.34,
r.m.s.e.
9.82)
associated
frontoposterior
networks
compared
models.
Structural
socioeconomic
inequality,
pollution
disparities
were
influential
predictors
increased
gaps,
especially
in
(
R
²
0.37,
F
0.59,
6.9).
An
ascending
to
impairment
was
found.
In
LAC,
observed
larger
gaps
females
control
groups
respective
males.
results
not
explained
by
variations
signal
quality,
demographics
or
acquisition
methods.
These
findings
provide
quantitative
framework
capturing
accelerated
aging.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 15, 2024
Abstract
In
the
study
of
neuro-electrophysiological
recordings,
aperiodic
neural
activity
–
with
no
characteristic
frequency
has
increasingly
become
a
common
feature
study.
This
interest
rapidly
extended
to
clinical
work,
many
reports
investigating
from
patients
broad
range
disorders.
work
typically
seeks
evaluate
as
putative
biomarker
relating
diagnosis
or
treatment
response,
and/or
potential
marker
underlying
physiological
activity.
There
is
thus
far
clear
consensus
on
if
and
how
relates
disorders,
nor
best
practices
for
it
in
research.
To
address
this,
this
systematic
literature
review,
following
PRISMA
guidelines,
examines
electrophysiological
recordings
human
psychiatric
neurological
finding
143
across
35
distinct
Reports
within
disorders
are
summarized
current
findings
examine
what
can
be
learned
pertains
analysis,
interpretations,
overall
utility
investigations.
Aperiodic
commonly
reported
relate
diagnoses,
31
reporting
significant
effect
diagnostic
related
studies.
However,
there
variation
consistency
results
heterogeneity
patient
groups,
disease
etiologies,
status
arising
themes
different
Overall,
variability
results,
potentially
confounding
covariates,
limitations
understanding
suggests
further
needed
before
established
pathological
physiology.
Finally,
series
recommendations
proposed,
based
findings,
limitations,
key
discussion
topics
assist
guiding
productive
future
studying
Project
Repository
The
project
repository
contains
code
&
data
project:
https://github.com/TomDonoghue/AperiodicClinical
Proceedings of the National Academy of Sciences,
Год журнала:
2025,
Номер
122(8)
Опубликована: Фев. 20, 2025
Understanding
the
evolving
dynamics
of
brain
throughout
life
is
pivotal
for
anticipating
and
evaluating
individual
health.
While
previous
research
has
described
age
effects
on
spectral
properties
neural
signals,
it
remains
unclear
which
ones
are
most
indicative
age-related
processes.
This
study
addresses
this
gap
by
analyzing
resting-state
data
obtained
from
magnetoencephalography
(MEG)
in
350
adults
(18
to
88
y).
We
employed
advanced
time-series
analysis
at
region
level
machine
learning
predict
age.
traditional
features
achieved
low
moderate
accuracy,
over
a
hundred
proved
superior.
Notably,
temporal
autocorrelation
(AC)
emerged
as
robust
predictor
Distinct
patterns
AC
within
visual
cortex
were
informative,
offering
versatile
measure
signal
changes
comprehensive
health
assessments
based
activity.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Май 2, 2025
Preschool
children,
who
spend
most
of
their
time
indoors,
and
the
effects
artificial
light
on
children's
health
performance
are
important.
Previous
studies
show
that
blue-enriched
white
(BWL)
has
significant
human
bodies,
but
only
a
few
have
specifically
examined
its
in
young
children.
Moreover,
due
to
physiological
differences
between
children
adults,
findings
from
BWL
adults
cannot
be
directly
applied
Therefore,
investigating
living
indoor
environments
is
crucial.
We
recruited
24
preschool
(age:
5
±
0.8
years;
12
girls
boys)
participate
within-subject,
randomized
crossover
study
involving
common
(CWL)
(450
lx,
Melanopic
EDI:
354.04
lx)
746.05
kindergarten
playroom.
Under
different
conditions,
underwent
tests
for
cardiac
activity
critical
flicker
fusion
frequency
(CFF),
as
well
psychomotor
vigilance
task
(PVT)
ruler
drop
test
(RDT).
The
results
indicated
had
Compared
CWL
exposure,
exposure
significantly
improved
activity,
alertness,
neuromuscular
response
slightly
increased
visual
fatigue.
Our
reveals
potential
improve
cognitive
functions,
particularly
response.
This
broadens
understanding
lighting
provides
theoretical
basis
designing
healthy
environment
