Dual impact of neuroinflammation on cognitive and motor impairments in Alzheimer's disease DOI Creative Commons
Sodiq Fakorede, Olubodun M. Lateef,

Wilson Amemewon Garuba

и другие.

Journal of Alzheimer s Disease Reports, Год журнала: 2025, Номер 9

Опубликована: Янв. 1, 2025

Neuroinflammation plays a crucial role in the progression of Alzheimer's disease (AD), contributing to both cognitive decline and motor impairment. This review examines dual impact neuroinflammatory processes, particularly activation microglia astrocytes, dysregulated release pro-inflammatory cytokines chemokines, on cognition balance AD. leads synaptic dysfunction, oxidative stress, mitochondrial impairment, which accelerate neuronal damage disrupt circuits, such as those cortex, basal ganglia, cerebellum. These disruptions result symptoms like gait disruption issues, reflecting close interplay between functions. In addition, we highlighted blood-brain barrier peripheral neuropathy increasing dysfunction. Despite promise anti-inflammatory treatments, clinical trials with non-steroidal drugs have yielded mixed results, underscoring need for early intervention more targeted therapies. Therefore, understanding mechanisms linking neuroinflammation impairments may guide development new therapeutic approaches aimed at mitigating complex pathology

Язык: Английский

The dual role of microglia in Alzheimer’s disease: from immune regulation to pathological progression DOI Creative Commons
Cong He, Baojiang Chen,

Hecai Yang

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Март 27, 2025

Alzheimer’s disease (AD) is a widespread neurodegenerative disorder and one of the major challenges for public health. Despite extensive research, role microglia in AD remains complex dual. The aim this review to summarize most recent advances research regarding dual concerning both immunomodulation pathological progression by considering mechanisms activation microglia, effects on Aβ clearance, tau pathology, impacts due genetic variations microglial functions. Among these findings are status M1 M2 phenotypes, crucial that variants like TREM2 have modulating response microglia. This describes how modulation signaling pathway might be exploited therapeutically treatment underlines relevance personalized medicine approach.

Язык: Английский

Процитировано

0
Dual impact of neuroinflammation on cognitive and motor impairments in Alzheimer's disease DOI Creative Commons
Sodiq Fakorede, Olubodun M. Lateef,

Wilson Amemewon Garuba

и другие.

Journal of Alzheimer s Disease Reports, Год журнала: 2025, Номер 9

Опубликована: Янв. 1, 2025

Neuroinflammation plays a crucial role in the progression of Alzheimer's disease (AD), contributing to both cognitive decline and motor impairment. This review examines dual impact neuroinflammatory processes, particularly activation microglia astrocytes, dysregulated release pro-inflammatory cytokines chemokines, on cognition balance AD. leads synaptic dysfunction, oxidative stress, mitochondrial impairment, which accelerate neuronal damage disrupt circuits, such as those cortex, basal ganglia, cerebellum. These disruptions result symptoms like gait disruption issues, reflecting close interplay between functions. In addition, we highlighted blood-brain barrier peripheral neuropathy increasing dysfunction. Despite promise anti-inflammatory treatments, clinical trials with non-steroidal drugs have yielded mixed results, underscoring need for early intervention more targeted therapies. Therefore, understanding mechanisms linking neuroinflammation impairments may guide development new therapeutic approaches aimed at mitigating complex pathology

Язык: Английский

Процитировано

0