Fibrillar amyloidosis and synaptic vesicle protein expression progress jointly in the cortex of a mouse model with β-amyloid pathology DOI Creative Commons

Lea H. Kunze,

Giovanna Palumbo, Johannes Gnörich

и другие.

NeuroImage, Год журнала: 2025, Номер unknown, С. 121165 - 121165

Опубликована: Март 1, 2025

Neurodegeneration, accumulation of β-amyloid (Aβ) plaques, and neuroinflammation are the major hallmarks Alzheimer's disease. Here, we aimed to investigate temporal spatial association between synaptic activity, Aβ plaque load, in an mouse model with limited neurodegeneration. 26 APPSL70 15 C57Bl/6 mice underwent longitudinal PET-scans [18F]UCB-H from onset levels strong load (5.3 - 11.0 months age) assess vesicle protein 2A (SV2A) expression, [18F]FBB determine fibrillar [18F]GE-180 [18F]F-DED microglial astroglial (re)activity. Statistical parametric mapping was performed uncover similarities binding patterns all four tracers. We found a continuous increase Aβ-PET 5.3 age, resulting significantly higher PET signal cortex, hippocampus, thalamus compared at age. Parallel increases SV2A-PET signals were observed cortex mice. revealed similar pattern Aβ- differences (dice coefficient 53 %). Patterns microglia activation showed stronger congruency SV2A expression 58 %) than reactive astrogliosis neurodegeneration comprise close activation. imaging may facilitate monitoring increased activity earliest phase AD.

Язык: Английский

Fibrillar amyloidosis and synaptic vesicle protein expression progress jointly in the cortex of a mouse model with β-amyloid pathology DOI Creative Commons

Lea H. Kunze,

Giovanna Palumbo, Johannes Gnörich

и другие.

NeuroImage, Год журнала: 2025, Номер unknown, С. 121165 - 121165

Опубликована: Март 1, 2025

Neurodegeneration, accumulation of β-amyloid (Aβ) plaques, and neuroinflammation are the major hallmarks Alzheimer's disease. Here, we aimed to investigate temporal spatial association between synaptic activity, Aβ plaque load, in an mouse model with limited neurodegeneration. 26 APPSL70 15 C57Bl/6 mice underwent longitudinal PET-scans [18F]UCB-H from onset levels strong load (5.3 - 11.0 months age) assess vesicle protein 2A (SV2A) expression, [18F]FBB determine fibrillar [18F]GE-180 [18F]F-DED microglial astroglial (re)activity. Statistical parametric mapping was performed uncover similarities binding patterns all four tracers. We found a continuous increase Aβ-PET 5.3 age, resulting significantly higher PET signal cortex, hippocampus, thalamus compared at age. Parallel increases SV2A-PET signals were observed cortex mice. revealed similar pattern Aβ- differences (dice coefficient 53 %). Patterns microglia activation showed stronger congruency SV2A expression 58 %) than reactive astrogliosis neurodegeneration comprise close activation. imaging may facilitate monitoring increased activity earliest phase AD.

Язык: Английский

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