Anterior Cingulate Cortex Causally Supports Meta-Learning DOI Creative Commons
Robert Louis Treuting, Kianoush Banaie Boroujeni,

Charles Grimes Gerrity

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 13, 2024

In dynamic environments with volatile rewards the anterior cingulate cortex (ACC) is believed to determine whether a visual object relevant and should be chosen. The ACC may achieve this by integrating reward information over time estimate which objects are worth explore avoided. Such higher-order meta-awareness about explored predicts that causally contributes choices when values of unknown must inferred from ongoing exploration. We tested suggestion in nonhuman primates using learning task varied number features could relevant, controlling motivational value choosing objects. During was transiently micro-stimulated subjects foveated to-be-chosen stimulus. found stimulation selectively impaired feature uncertainty were high, linked deficit outcomes for feature-specific credit assignment. Application an adaptive reinforcement model confirmed primary weighting prediction errors led meta-learning impairment adaptively increase exploration during use working memory support learning. These findings provide causal evidence history traces essential meta-adjusting exploration-exploitation balance strength behavior.

Язык: Английский

Efficacy and Safety of High-Dose and personalized TBS on Post-stroke Cognitive Impairment: A Randomized Controlled Trial DOI Creative Commons
Jianxun Ren, Wenlong Su, Ying Zhou

и другие.

Brain stimulation, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1
Left Ventral Caudate Functional Connectivity Mediates the Relationship Between Habitual Responding and Alcohol Use DOI Creative Commons

Lindsey Fisher-Fox,

Mario Džemidžić,

McKenzie R. Cox

и другие.

European Journal of Neuroscience, Год журнала: 2025, Номер 61(10)

Опубликована: Май 1, 2025

Preclinical studies posit that habitual behaviour is an important mechanism in the development of alcohol use disorder (AUD), but human findings are unclear. The goals this study were to test a behavioural measure habit formation, Slips Action Task (SOAT), humans and identify brain-based mechanisms explaining relationship between use. Thirty-six participants (63.9% female, mean age = 30.58, SD 9.73, 69.4% White, 83.3% Not Hispanic/Latino) who endorsed heavy drinking completed self-report measures, SOAT (lower scores higher formation), 2.5-h intravenous self-administration session, resting-state functional magnetic resonance imaging scan. Three seed regions-bilateral ventral caudate, nucleus accumbens dorsal caudate-were assessed for significant whole brain connectivity (FC) associations with (cluster-level pFWE < 0.05 at cluster-forming threshold p 0.001). Two clusters survived Bonferroni correction (cluster 0.008): FC left caudate middle frontal gyrus correlated negatively, while NAc right central operculum positively, score. score was unrelated outcomes; however, there indirect average drinks per day through gyrus. A similar trend seen cumulative work fell short significance. Habit formation's may function neuroadaptations caudate. More needed better characterize objective formation laboratory additional laboratory-, alcohol-specific, imaging- ambulatory-based metrics.

Язык: Английский

Процитировано

0
Anterior Cingulate Cortex Causally Supports Meta-Learning DOI Creative Commons
Robert Louis Treuting, Kianoush Banaie Boroujeni,

Charles Grimes Gerrity

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 13, 2024

In dynamic environments with volatile rewards the anterior cingulate cortex (ACC) is believed to determine whether a visual object relevant and should be chosen. The ACC may achieve this by integrating reward information over time estimate which objects are worth explore avoided. Such higher-order meta-awareness about explored predicts that causally contributes choices when values of unknown must inferred from ongoing exploration. We tested suggestion in nonhuman primates using learning task varied number features could relevant, controlling motivational value choosing objects. During was transiently micro-stimulated subjects foveated to-be-chosen stimulus. found stimulation selectively impaired feature uncertainty were high, linked deficit outcomes for feature-specific credit assignment. Application an adaptive reinforcement model confirmed primary weighting prediction errors led meta-learning impairment adaptively increase exploration during use working memory support learning. These findings provide causal evidence history traces essential meta-adjusting exploration-exploitation balance strength behavior.

Язык: Английский

Процитировано

1