Decoding sTREM2: its impact on Alzheimer’s disease – a comprehensive review of mechanisms and implications DOI Creative Commons

Cui Lin,

Yu Kong, Qian Chen

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Июнь 7, 2024

Soluble Triggering Receptor Expressed on Myeloid Cells 2 (sTREM2) plays a crucial role in the pathogenesis of Alzheimer's disease (AD). This review comprehensively examines sTREM2's involvement AD, focusing its regulatory functions microglial responses, neuroinflammation, and interactions with key pathological processes. We discuss dynamic changes sTREM2 levels cerebrospinal fluid plasma throughout AD progression, highlighting potential as therapeutic target. Furthermore, we explore impact genetic variants expression interplay other risk genes. The evidence presented this suggests that modulating activity could influence trajectory, making it promising avenue for future research drug development. By providing holistic understanding multifaceted aims to guide studies inspire novel strategies.

Язык: Английский

Recent advancement in understanding of Alzheimer's disease: Risk factors, subtypes, and drug targets and potential therapeutics DOI

Sneh Prabha,

Mohd Sajad,

Gulam Mustafa Hasan

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 101, С. 102476 - 102476

Опубликована: Авг. 31, 2024

Язык: Английский

Процитировано

14
Decoding sTREM2: its impact on Alzheimer’s disease – a comprehensive review of mechanisms and implications DOI Creative Commons

Cui Lin,

Yu Kong, Qian Chen

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Июнь 7, 2024

Soluble Triggering Receptor Expressed on Myeloid Cells 2 (sTREM2) plays a crucial role in the pathogenesis of Alzheimer's disease (AD). This review comprehensively examines sTREM2's involvement AD, focusing its regulatory functions microglial responses, neuroinflammation, and interactions with key pathological processes. We discuss dynamic changes sTREM2 levels cerebrospinal fluid plasma throughout AD progression, highlighting potential as therapeutic target. Furthermore, we explore impact genetic variants expression interplay other risk genes. The evidence presented this suggests that modulating activity could influence trajectory, making it promising avenue for future research drug development. By providing holistic understanding multifaceted aims to guide studies inspire novel strategies.

Язык: Английский

Процитировано

5