Excitation-Inhibition Imbalance in Migraine: From Neurotransmitters to Brain Oscillations

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(12), С. 10093 - 10093

Опубликована: Июнь 13, 2023

Migraine is among the most common and debilitating neurological disorders typically affecting people of working age. It characterised by a unilateral, pulsating headache often associated with severe pain. Despite intensive research, there still little understanding pathophysiology migraine. At electrophysiological level, altered oscillatory parameters have been reported within alpha gamma bands. molecular glutamate GABA concentrations reported. However, has cross-talk between these lines research. Thus, relationship activity neurotransmitter remains to be empirically traced. Importantly, how indices link back sensory processing clearly established as yet. Accordingly, pharmacologic treatments mostly symptom-based, yet sometimes proving ineffective in resolving pain or related issues. This review provides an integrative theoretical framework excitation-inhibition imbalance for current evidence address outstanding questions concerning We propose use computational modelling rigorous formulation testable hypotheses on mechanisms homeostatic development mechanism-based pharmacological neurostimulation interventions.

Язык: Английский

---

Application and research progress of different frequency tACS in stroke rehabilitation: A systematic review

Brain Research, Год журнала: 2025, Номер 1852, С. 149521 - 149521

Опубликована: Фев. 19, 2025

Язык: Английский

---

Normative characterization of age-related periodic and aperiodic activity in resting-state clinical EEG recordings

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 19, 2024

Abstract Objective Non-invasive oscillatory brain stimulation techniques target the activity of and have several potential therapeutic applications in clinical context. The aim these analyses from routine EEG recordings was to provide normative values physiological age-related (periodic) non-rhythmic (aperiodic) activity. Methods We analyzed 532 EEGs patients between 8 92 years age. segments were preprocessed, power spectrum computed using a multitaper method. decomposed into periodic (peak power, frequency, bandwidth) aperiodic (intercept exponent) components. Linear regression models used investigate changes parameters. Results observed significant global alpha (- 0.015 Hz/year) gamma (+ 0.013 + 0.031Hz/year) peak frequency as well exponent 0.003 - 0.004 μV 2 /Hz/year). In other parameters there solely regional or no changes. Conclusions Decomposing components allows for characterization Significance This study provides first spectrum-wide activity, relevant non-invasive with alternating current targeting ongoing Highlights Alpha decreases age, while accelerates. Age-related theta result flattening slope, not decreased is essential when characterizing

Язык: Английский

---

Theta transcranial alternating current stimulation over the prefrontal cortex enhances theta power and working memory performance

Frontiers in Psychiatry, Год журнала: 2025, Номер 15

Опубликована: Янв. 14, 2025

Introduction Transcranial alternating current stimulation (tACS) is a promising tool for modulating brain oscillations. This study investigated whether 5 Hz tACS could modulate neural oscillations in the prefrontal cortex and how this modulation impacts performance working memory (WM) tasks. Method In two sessions, 28 healthy participants received or sham over left dorsolateral (DLPFC) while performing tasks with high low WM loads. Resting-state EEG was recorded before after stimulations minutes. power measured at electrodes surrounding site. Results The results showed that significantly improved reaction time (RT) compared to stimulation. effect task-specific, as RT hit responses only load trials, no impact on low-load trials. Moreover, increased theta band pre-stimulation levels. Discussion These findings demonstrate applied DLPFC modulates post-stimulation sites – known after-effects. Furthermore, suggest enhances response speed by elevating task-related activity an optimal level task performance. Conclusion summary, highlight potential of technique specific oscillations, implications research therapeutic interventions.

Язык: Английский

---

Alpha rhythm transcranial electrical stimulation to inferior parietal cortex increases alpha power and phase synchrony while attending to mind–body self-states

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

---

Efficacy and Safety of Bilateral Deep Brain Stimulation (DBS) for Severe Alzheimer's Disease: A Comparative Analysis of Fornix Versus Basal Ganglia of Meynert

CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(4)

Опубликована: Апрель 1, 2025

ABSTRACT Background Deep brain stimulation (DBS) is a novel therapy for severe Alzheimer's disease (AD). However, there an ongoing debate regarding the optimal target DBS, particularly fornix and basal ganglia of Meynert (NBM). Objective This study aimed to investigate safety efficacy DBS AD compare NBM as potential targets. Methods We conducted prospective, nonrandomized clinical involving 20 patients with (MMSE score 0 10, CDR level 3) from January 2015 August 2022, comprising 12 males eight females, mean age 59.05 ± 6.45 years. All underwent treatment, among which 14 received bilateral implantation, while six implantation in NBM. Electrical commenced 1 month postoperatively. assessed before surgery, followed by evaluations at month, 3 months, 6 months poststimulation. Primary outcome measures focused on changes cognitive function, using MMSE, MoCA, ADAS‐Cog, scales. Secondary encompassed quality life, caregiver burden, neuropsychiatric symptoms, sleep disturbances, evaluated through BI, FAQ, FIM, ZBI, NPI, HAMA, HAMD, PSQI Results tolerated well, no serious adverse effects reported. Early on, significantly improved function life. Long‐term benefits include improvement symptoms disorders alleviation burden. Comparison between targeting revealed significant differences overall scale scores. upon deeper analysis, NBM‐DBS exhibited more pronounced NPI Conclusion therapeutic approach AD, capable improving patients' symptoms. Notably, showed distinct advantages ameliorating providing valuable insights clinically selecting target. Trial Registration ClinicalTrials.gov identifier: NCT03115814

Язык: Английский

---

Individual alpha frequency tACS reduces static functional connectivity across the default mode network

Frontiers in Human Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Май 14, 2025

Research on the influence of transcranial alternating current stimulation over alpha functional connectivity (FC) is scarce, even when it poses as a potential treatment for various diseases. This study aimed to investigate effects individual frequency tACS (IAF-tACS) FC within default mode network (DMN) in healthy individuals, particularly following triple model. 27 participants were recruited, who underwent 20-min IAF-tACS session parieto-occipital areas and three magnetoencephalography (MEG) recordings: two pre-stimulation one post-stimulation. Participants randomly assigned either or sham group. Both dynamic (dFC) static (sFC) evaluated through leakage corrected amplitude envelope correlation (AEC-c). Statistical analyses compared both Pre-Post ratio between groups t-tests intragroup changes repeated measures t-tests, with FDR correction applied account multiple comparisons. An additional analysis simulated cortical folding effect FC. significantly decreased sFC intra- inter-DMN links group group, special antero-posterior hubs DMN. Negative correlations found AEC-c power alterations posterior DMN areas, suggesting complex interaction electric field direction. On other hand, dFC increased groups, no between-group differences found. Against our initial hypothesis, reduced DMN, possibly due phase disparities introduced by gyrification. These findings suggest that might modulate more manner than previously thought, highlighting need further research into personalized application neuromodulation techniques, well its therapeutic implications conditions like Alzheimer's disease.

Язык: Английский

---

Repeated application of bifocal transcranial alternating current stimulation improves network connectivity but not response inhibition: a double-blind sham control study.

Cerebral Cortex, Год журнала: 2025, Номер 35(5)

Опубликована: Май 1, 2025

Mounting evidence suggests that transcranial alternating current stimulation can enhance response inhibition, a cognitive process crucial for sustained effort and decision-making. However, most studies have focused on within-session effects, with limited investigation into the effects of repeated applications, which are clinical applications. We examined bifocal targeting right inferior frontal gyrus pre-supplementary motor area functional connectivity, simulated driving performance. Thirty young adults (18-35 yr) received either sham or (20 Hz, 20 min) across 5 sessions over 2 wk. Resting-state electroencephalography assessed connectivity between at baseline, final session, 7-d follow-up. Response inhibition was measured using stop-signal task, performance before after intervention. The results showed significant improvements in group sessions, though braking remained unchanged. while not targeted behavior, general potentially improved following stimulation, participants maintaining stable behavior alongside increased spare attentional capacity. These findings suggest may cortical related cognitive-motor processes, supporting its potential

Язык: Английский

---

Modulation of brain activity in brain-injured patients with a disorder of consciousness in intensive care with repeated 10-Hz transcranial alternating current stimulation (tACS): a randomised controlled trial protocol

BMJ Open, Год журнала: 2024, Номер 14(7), С. e078281 - e078281

Опубликована: Июль 1, 2024

Introduction Therapeutic interventions for disorders of consciousness lack consistency; evidence supports non-invasive brain stimulation, but few studies assess neuromodulation in acute-to-subacute brain-injured patients. This study aims to validate the feasibility and effect a multi-session transcranial alternating current stimulation (tACS) intervention subacute patients on recovery consciousness, related oscillations network dynamics. Methods analyses The is comprised two phases: validation phase (n=12) randomised controlled trial (n=138). Both phases will be conducted medically stable adult (traumatic injury hypoxic-ischaemic encephalopathy), with Glasgow Coma Scale score ≤12 after continuous sedation withdrawal. Recruitment occur at intensive care unit Level 1 Trauma Centre Montreal, Quebec, Canada. includes 20 min 10 Hz tACS mA intensity or sham session over parieto-occipital cortical sites, repeated five consecutive days. current’s frequency targets alpha (8–13 Hz), known associated consciousness. Resting-state electroencephalogram (EEG) recorded four times daily days: pre post-intervention, 60 120 post-tACS. Two additional recordings included: 24 hours 1-week post-protocol. Multimodal measures (blood samples, pupillometry, behavioural assessments (Coma Recovery Scale-revised), actigraphy measures) acquired from baseline up week stimulation. EEG signal analysis focus bandwidth Hz) using spectral functional analyses. Phone 3, 6 12 months post-tACS, measure long-term recovery, quality life caregivers’ burden. Ethics dissemination Ethical approval this has been granted by Research Board CIUSSS du Nord-de-l’Île-de-Montréal (Project ID 2021–2279). findings two-phase submitted publication peer-reviewed academic journal presentation conferences. trial’s results published public registry database (ClinicalTrials.gov). Trial registration number NCT05833568 .

Язык: Английский

---

Alpha and beta/low-gamma frequency bands may have distinct neural origin and function during post-stroke walking

Experimental Brain Research, Год журнала: 2024, Номер 242(10), С. 2309 - 2327

Опубликована: Авг. 6, 2024

Язык: Английский

---