Individualized non-invasive deep brain stimulation of the basal ganglia using transcranial ultrasound stimulation DOI Creative Commons
Ghazaleh Darmani, Hamidreza Ramezanpour, Can Sarica

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Март 19, 2025

Transcranial ultrasound stimulation (TUS) offers precise, non-invasive neuromodulation, though its impact on human deep brain structures remains underexplored. Here we examined TUS-induced changes in the basal ganglia of 10 individuals with movement disorders (Parkinson's disease and dystonia) 15 healthy participants. Local field potentials were recorded using (DBS) leads globus pallidus internus (GPi). Compared to sham, theta burst TUS (tbTUS) increased power during stimulation, while Hz enhanced beta power, effects lasting up 40 min. In participants, a stop-signal task assessed tbTUS GPi, pulvinar serving as an active sham. GPi prolonged reaction times, indicating impaired response inhibition, whereas had no effect. These findings provide direct electrophysiological evidence target engagement specificity structures, suggesting potential noninvasive DBS strategy for neurological psychiatric disorders. is method modulate activity. Using recordings from implanted electrodes, showed that engages internus, neural oscillations behavior.

Язык: Английский

Individualized non-invasive deep brain stimulation of the basal ganglia using transcranial ultrasound stimulation DOI Creative Commons
Ghazaleh Darmani, Hamidreza Ramezanpour, Can Sarica

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Март 19, 2025

Transcranial ultrasound stimulation (TUS) offers precise, non-invasive neuromodulation, though its impact on human deep brain structures remains underexplored. Here we examined TUS-induced changes in the basal ganglia of 10 individuals with movement disorders (Parkinson's disease and dystonia) 15 healthy participants. Local field potentials were recorded using (DBS) leads globus pallidus internus (GPi). Compared to sham, theta burst TUS (tbTUS) increased power during stimulation, while Hz enhanced beta power, effects lasting up 40 min. In participants, a stop-signal task assessed tbTUS GPi, pulvinar serving as an active sham. GPi prolonged reaction times, indicating impaired response inhibition, whereas had no effect. These findings provide direct electrophysiological evidence target engagement specificity structures, suggesting potential noninvasive DBS strategy for neurological psychiatric disorders. is method modulate activity. Using recordings from implanted electrodes, showed that engages internus, neural oscillations behavior.

Язык: Английский

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