Mechanisms and Functional Implications of Adult Neurogenesis

Cell, Год журнала: 2008, Номер 132(4), С. 645 - 660

Опубликована: Фев. 1, 2008

Язык: Английский

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Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

Neuron, Год журнала: 2011, Номер 70(4), С. 687 - 702

Опубликована: Май 1, 2011

Язык: Английский

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New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

Nature reviews. Neuroscience, Год журнала: 2010, Номер 11(5), С. 339 - 350

Опубликована: Март 31, 2010

Язык: Английский

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Dynamics of Hippocampal Neurogenesis in Adult Humans

Cell, Год журнала: 2013, Номер 153(6), С. 1219 - 1227

Опубликована: Июнь 1, 2013

Язык: Английский

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Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

Nature, Год журнала: 2011, Номер 472(7344), С. 466 - 470

Опубликована: Апрель 1, 2011

Язык: Английский

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Immune modulation of learning, memory, neural plasticity and neurogenesis

Brain Behavior and Immunity, Год журнала: 2010, Номер 25(2), С. 181 - 213

Опубликована: Окт. 22, 2010

Язык: Английский

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Adult hippocampal neurogenesis in depression

Nature Neuroscience, Год журнала: 2007, Номер 10(9), С. 1110 - 1115

Опубликована: Авг. 28, 2007

Язык: Английский

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Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

Cell, Год журнала: 2016, Номер 167(4), С. 897 - 914

Опубликована: Ноя. 1, 2016

Язык: Английский

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Adult hippocampal neurogenesis and its role in Alzheimer's disease

Molecular Neurodegeneration, Год журнала: 2011, Номер 6(1), С. 85 - 85

Опубликована: Янв. 1, 2011

The hippocampus, a brain area critical for learning and memory, is especially vulnerable to damage at early stages of Alzheimer's disease (AD). Emerging evidence has indicated that altered neurogenesis in the adult hippocampus represents an event course AD. Although causal links have not been established, variety key molecules involved AD pathogenesis shown impact new neuron generation, either positively or negatively. From functional point view, hippocampal plays important role structural plasticity network maintenance. Therefore, dysfunctional resulting from subtle manifestations may turn exacerbate neuronal vulnerability contribute memory impairment, whereas enhanced be compensatory response represent endogenous repair mechanism. Here we review recent findings on alterations associated with AD, discuss potential neurogenesis-based diagnostics therapeutic strategies

Язык: Английский

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Neurogenesis in the Adult Hippocampus

Cold Spring Harbor Perspectives in Biology, Год журнала: 2015, Номер 7(9), С. a018812 - a018812

Опубликована: Сен. 1, 2015

Gerd Kempermann1, Hongjun Song2 and Fred H. Gage3 1German Center for Neurodegenerative Diseases (DZNE) Dresden CRTD—Center Regenerative Therapies at Technische Universität Dresden, 01307 Germany 2Institute Cell Engineering, Stem Program ICW, The John Hopkins University, Baltimore, Maryland 21205 3Laboratory of Genetics LOG-G, Salk Institute Biological Studies, La Jolla, California 92037 Correspondence: gerd.kempermann{at}dzne.de

Язык: Английский

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