Advances in Genomics and Genetics,
Год журнала:
2015,
Номер
unknown, С. 131 - 131
Опубликована: Март 1, 2015
Eating
disorders
(EDs)
are
serious
psychiatric
conditions
influenced
by
biological,
psychological,
and
sociocultural
factors.
A
better
understanding
of
the
genetics
these
complex
traits
development
more
sophisticated
molecular
biology
tools
have
advanced
our
etiology
EDs.
The
aim
this
review
is
to
critically
evaluate
literature
on
genetic
research
conducted
three
major
EDs:
anorexia
nervosa
(AN),
bulimia
(BN),
binge
eating
disorder
(BED).
We
will
first
diagnostic
criteria,
clinical
features,
prevalence,
prognosis
AN,
BN,
BED,
followed
a
family,
twin,
adoption
studies.
then
history
studies
EDs
covering
linkage
analysis,
candidate
gene
association
studies,
genome-wide
study
rare
variants
in
Our
also
incorporates
translational
perspective
animal
models
ED-related
phenotypes.
Finally,
we
nascent
field
epigenetics
look
forward
future
directions
for
ED
research.
The American Journal of Human Genetics,
Год журнала:
2014,
Номер
94(5), С. 677 - 694
Опубликована: Апрель 24, 2014
Rare
copy-number
variation
(CNV)
is
an
important
source
of
risk
for
autism
spectrum
disorders
(ASDs).
We
analyzed
2,446
ASD-affected
families
and
confirmed
excess
genic
deletions
duplications
in
affected
versus
control
groups
(1.41-fold,
p
=
1.0
×
10(-5))
increase
subjects
carrying
exonic
pathogenic
CNVs
overlapping
known
loci
associated
with
dominant
or
X-linked
ASD
intellectual
disability
(odds
ratio
12.62,
2.7
10(-15),
∼3%
subjects).
Pathogenic
CNVs,
often
showing
variable
expressivity,
included
rare
de
novo
inherited
events
at
36
loci,
implicating
ASD-associated
genes
(CHD2,
HDAC4,
GDI1)
previously
linked
to
other
neurodevelopmental
disorders,
as
well
such
SETD5,
MIR137,
HDAC9.
Consistent
hypothesized
gender-specific
modulators,
females
were
more
likely
have
highly
penetrant
(p
0.017)
also
overrepresented
among
fragile
X
syndrome
protein
targets
0.02).
Genes
by
and/or
loss-of-function
single-nucleotide
variants
converged
on
networks
related
neuronal
signaling
development,
synapse
function,
chromatin
regulation.
Annual Review of Neuroscience,
Год журнала:
2012,
Номер
35(1), С. 227 - 247
Опубликована: Май 20, 2012
Memory
consolidation
is
the
hypothetical
process
in
which
an
item
memory
transformed
into
a
long-term
form.
It
commonly
addressed
at
two
complementary
levels
of
description
and
analysis:
cellular/synaptic
level
(synaptic
consolidation)
brain
systems
(systems
consolidation).
This
article
focuses
on
selected
recent
advances
research,
including
reconsolidation
items,
mechanisms
transformation
content
cue-dependency
items
over
time,
as
well
role
rest
sleep
consolidating
shaping
memories.
Taken
together,
picture
that
emerges
dynamic
engrams
are
formed,
modified,
remodified
time
by
using
synaptic
subroutines.
implies
that,
contrary
to
interpretations
have
dominated
neuroscience
for
while,
but
similar
long-standing
cognitive
concepts,
least
some
may
never
really
come
end.
Philosophical Transactions of the Royal Society B Biological Sciences,
Год журнала:
2013,
Номер
369(1633), С. 20130288 - 20130288
Опубликована: Дек. 3, 2013
The
synaptic
plasticity
and
memory
hypothesis
asserts
that
activity-dependent
is
induced
at
appropriate
synapses
during
formation
both
necessary
sufficient
for
the
encoding
trace
storage
of
type
mediated
by
brain
area
in
which
it
observed.
Criteria
establishing
necessity
sufficiency
such
mediating
have
been
identified
are
here
reviewed
relation
to
new
work
using
some
diverse
techniques
contemporary
neuroscience.
Evidence
derived
optical
imaging,
molecular-genetic
optogenetic
conjunction
with
behavioural
analyses
continues
offer
support
idea
changing
strength
connections
between
neurons
one
major
mechanisms
engrams
stored
brain.
Genes Brain & Behavior,
Год журнала:
2013,
Номер
13(1), С. 69 - 86
Опубликована: Ноя. 28, 2013
To
date,
there
is
rapidly
increasing
evidence
for
host-microbe
interaction
at
virtually
all
levels
of
complexity,
ranging
from
direct
cell-to-cell
communication
to
extensive
systemic
signalling,
and
involving
various
organs
organ
systems,
including
the
central
nervous
system.
As
such,
discovery
that
differential
microbial
composition
associated
with
alterations
in
behaviour
cognition
has
significantly
contributed
establishing
microbiota-gut-brain
axis
as
an
extension
well-accepted
gut-brain
concept.
Many
efforts
have
been
focused
on
delineating
a
role
this
health
disease,
stress-related
disorders
such
depression,
anxiety
irritable
bowel
syndrome
neurodevelopmental
autism.
There
also
growing
appreciation
epigenetic
mechanisms
shaping
brain
behaviour.
However,
epigenetics
informing
interactions
received
little
attention
date.
This
despite
fact
are
many
plausible
routes
between
host-microbiota
dialogue.
From
new
perspective
we
put
forward
novel,
yet
testable,
hypotheses.
Firstly,
suggest
gut-microbial
products
can
affect
chromatin
plasticity
within
their
host's
turn
leads
changes
neuronal
transcription
eventually
alters
host
Secondly,
argue
microbiota
important
mediator
gene-environment
interactions.
Finally,
reason
itself
may
be
viewed
entity.
In
conclusion,
fields
(neuro)epigenetics
microbiology
converging
more
interdisciplinary
studies
necessary
unravel
full
range
interaction.
