Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(8), С. 3891 - 3891

Опубликована: Апрель 9, 2021

Fibromyalgia is a syndrome characterized by chronic and widespread musculoskeletal pain, often accompanied other symptoms, such as fatigue, intestinal disorders alterations in sleep mood. It estimated that two to eight percent of the world population affected fibromyalgia. From medical point view, this pathology still presents inexplicable aspects. known fibromyalgia caused central sensitization phenomenon dysfunction neuro-circuits, which involves perception, transmission processing afferent nociceptive stimuli, with prevalent manifestation pain at level locomotor system. In recent years, pathogenesis has also been linked factors, inflammatory, immune, endocrine, genetic psychosocial factors. A rheumatologist typically makes diagnosis when patient describes history spreading all quadrants body for least three months digital pressure 11 out 18 allogenic points, called tender points. does not involve organic damage, several diagnostic approaches have developed including analysis genetic, epigenetic serological biomarkers. Symptoms begin after physical or emotional trauma, but many cases, there appears be no obvious trigger. Women are more prone developing disease than men. Unfortunately, conventional therapies target produce limited benefits. They remain largely pharmacological nature tend treat symptomatic aspects various reported patient. The statistics, however, highlight fact 90% people turn complementary medicine manage their symptoms.

Язык: Английский

---

The Transition of Acute Postoperative Pain to Chronic Pain: An Integrative Overview of Research on Mechanisms

Journal of Pain, Год журнала: 2016, Номер 18(4), С. 359.e1 - 359.e38

Опубликована: Ноя. 28, 2016

Язык: Английский

---

Pain vulnerability: a neurobiological perspective

Nature Neuroscience, Год журнала: 2014, Номер 17(2), С. 192 - 200

Опубликована: Янв. 28, 2014

Язык: Английский

---

Neuroplasticity Underlying the Comorbidity of Pain and Depression

Neural Plasticity, Год журнала: 2015, Номер 2015, С. 1 - 16

Опубликована: Янв. 1, 2015

Acute pain induces depressed mood, and chronic is known to cause depression. Depression, meanwhile, can also adversely affect behaviors ranging from symptomology treatment response. Pain depression independently induce long-term plasticity in the central nervous system (CNS). Comorbid conditions, however, have distinct patterns of neural activation. We performed a review changes circuitry molecular signaling pathways that may underlie this complex relationship between discussed some current future therapies are based on understanding CNS occurs with

Язык: Английский

---

Reframing chronic pain as a disease, not a symptom: rationale and implications for pain management

Postgraduate Medicine, Год журнала: 2019, Номер 131(3), С. 185 - 198

Опубликована: Янв. 31, 2019

Chronic pain is a common public health problem that has detrimental impact on patient health, quality of life (QoL), and function, poses substantial socioeconomic burden. Evidence supports the redefinition chronic as distinct disease entity, not simply symptom injury or illness. conditions are characterized by three types pathophysiology (i.e. nociceptive, neuropathic, centralized pain/central sensitization) influenced cluster coexisting psychosocial factors. Negative risk/vulnerability factors (e.g. mood sleep disturbances) positive resilience/protective social/interpersonal relationships active coping) interact with neurobiology to determine patients' unique experience. Viewing through biopsychosocial lens, instead purely biomedical one, clinicians need adopt practical integrated management approach. Thorough assessment focuses whole (not just pain), including comorbidities, cognitive/emotional/behavioral characteristics, social environment, QoL/functional impairment. As for other complex illnesses, treatment plan can be developed based subtype profile, incorporating pharmacotherapy self-management modalities. Preferred pharmacologic primarily associated nociception osteoarthritis) includes acetaminophen non-steroidal anti-inflammatory drugs, whereas preferred neuropathy central sensitization fibromyalgia) tricyclic compounds, serotonin-norepinephrine reuptake inhibitors, α2δ ligands. Education, exercise, cognitive behavioral therapy, many non-pharmacological approaches, alone combined pharmacotherapy, have been shown effective any type pain, although they remain underutilized due lack awareness their benefits reimbursement obstacles.

Язык: Английский

---

Fibromyalgia: Genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers

Molecular Pain, Год журнала: 2018, Номер 15

Опубликована: Ноя. 29, 2018

Fibromyalgia is a disease characterized by chronic widespread pain with additional symptoms, such as joint stiffness, fatigue, sleep disturbance, cognitive dysfunction, and depression. Currently, fibromyalgia diagnosis based exclusively on comprehensive clinical assessment, according to 2016 ACR criteria, but validated biological biomarkers associated have not yet been identified. Genome-wide association studies investigated genes potentially involved in pathogenesis highlighting that genetic factors are possibly responsible for up 50% of the susceptibility. Potential candidate found SLC64A4, TRPV2, MYT1L, NRXN3. Furthermore, gene-environmental interaction has proposed triggering mechanism, through epigenetic alterations: In particular, appears be hypomethylated DNA pattern, implicated stress response, repair, autonomic system subcortical neuronal abnormalities. Differences genome-wide expression profile microRNAs were among multiple tissues, indicating involvement distinct processes pathogenesis. Further should dedicated strength these preliminary findings, larger multicenter cohorts, identify reliable directions biomarker research practice.

Язык: Английский

---

The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis

British Journal of Anaesthesia, Год журнала: 2023, Номер 130(6), С. 729 - 746

Опубликована: Апрель 21, 2023

BackgroundAdverse childhood experiences have been linked to increased multimorbidity, with physical and mental health consequences throughout life. Chronic pain is often associated mood disorders, such as major depressive disorder (MDD); both adverse experiences. It unclear how the effect of on neural processing impacts vulnerability chronic pain, MDD, or both, whether there are shared mechanisms. We aimed assess evidence for central changes in subjects using systematic review meta-analysis.MethodsElectronic databases were systematically searched neuroimaging studies experiences, both. Two independent reviewers screened title, abstracts, full text, assessed quality. After extraction data, activation likelihood estimate meta-analysis was performed identify significant brain regions these comorbidities.ResultsForty-nine 2414 eligible, which 43 investigated MDD six pain. None together. Functional structural abnormalities identified superior frontal, lingual gyrus, hippocampus, insula, putamen, temporal, inferior temporal anterior cerebellum patients exposed In addition, function exposure cingulate parietal lobule, precuneus task-based functional MRI studies.ConclusionsWe found that can result different alterations adults compared those without experiences.Systematic protocolPROSPERO CRD42021233989.

Язык: Английский

---

Transcriptional regulator PRDM12 is essential for human pain perception

Nature Genetics, Год журнала: 2015, Номер 47(7), С. 803 - 808

Опубликована: Май 25, 2015

Язык: Английский

---

HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain

Pain, Год журнала: 2013, Номер 154(9), С. 1668 - 1679

Опубликована: Май 18, 2013

Histone deacetylase inhibitors (HDACIs) interfere with the epigenetic process of histone acetylation and are known to have analgesic properties in models chronic inflammatory pain. The aim this study was determine whether these compounds could also affect neuropathic Different class I HDACIs were delivered intrathecally into rat spinal cord traumatic nerve injury antiretroviral drug-induced peripheral neuropathy (stavudine, d4T). Mechanical thermal hypersensitivity attenuated by 40% 50% as a result HDACI treatment, but only if started before any insult. drugs globally increased cord, appeared no measurable effects relevant dorsal root ganglia treatment paradigm, suggesting that potential mechanism should be sought central nervous system. Microarray analysis RNA revealed signature specific compound used (MS-275) suggested its main effect mediated through HDAC1. Taken together, data support role for emergence

Язык: Английский

---

A new perspective on the anterior cingulate cortex and affective pain

Neuroscience & Biobehavioral Reviews, Год журнала: 2018, Номер 90, С. 200 - 211

Опубликована: Апрель 24, 2018

Язык: Английский

---