The anticipation and outcome phases of reward and loss processing: A neuroimaging meta‐analysis of the monetary incentive delay task DOI Creative Commons
Stuart Oldham, Carsten Murawski, Alex Fornito

и другие.

Human Brain Mapping, Год журнала: 2018, Номер 39(8), С. 3398 - 3418

Опубликована: Апрель 25, 2018

Abstract The processing of rewards and losses are crucial to everyday functioning. Considerable interest has been attached investigating the anticipation outcome phases reward loss processing, but results date have inconsistent. It is unclear if a or recruit similar distinct brain regions. In particular, while striatum widely found be active when anticipating reward, whether it activates in response as well remains ambiguous. Furthermore, concerning orbitofrontal/ventromedial prefrontal regions, activation often observed during receipt. However, this area well. We ran an Activation Likelihood Estimation meta‐analysis 50 fMRI studies, which used Monetary Incentive Delay Task (MIDT), identify regions implicated rewards, losses, receipt reward. Anticipating recruits overlapping areas including striatum, insula, amygdala thalamus, suggesting that generalised neural system initiates motivational processes independent valence. were recruited only outcome, likely representing value received. Our findings help clarify substrates different advance neurobiological models these processes.

Язык: Английский

Reward and aversion in a heterogeneous midbrain dopamine system DOI
Stephan Lammel, Byung Kook Lim, Robert C. Malenka

и другие.

Neuropharmacology, Год журнала: 2013, Номер 76, С. 351 - 359

Опубликована: Апрель 8, 2013

Язык: Английский

Процитировано

751

Reward processing dysfunction in major depression, bipolar disorder and schizophrenia DOI
Alexis E. Whitton, Michael T. Treadway, Diego A. Pizzagalli

и другие.

Current Opinion in Psychiatry, Год журнала: 2014, Номер 28(1), С. 7 - 12

Опубликована: Ноя. 20, 2014

Purpose of review This article reviews the recent literature on reward processing dysfunction in major depression (MDD), bipolar disorder and schizophrenia, with a focus approach motivation, learning reward-based decision-making. Recent findings Emerging evidence indicates presence abnormalities across all three disorders, supporting transdiagnostic approach. In particular, are consistent role abnormal phasic striatal dopamine signaling, which is critical for reinforcement learning, efficient mobilization effort to obtain allocation attention reward-predictive cues. Specifically, reward-related signaling appears blunted MDD negative symptoms elevated (hypo)mania, contextually misallocated positive psychosis. However, whether shared or distinct pathophysiological mechanisms contribute disorders remains unknown. Summary New MDD, schizophrenia has led greater understanding neural processes associated symptomatology common these conditions (e.g., anhedonia). Dissecting various subcomponents that map onto partially different neurobiological pathways investigating their dysregulation psychiatric holds promise developing more targeted, hopefully efficacious treatment intervention strategies.

Язык: Английский

Процитировано

678

Dissociable dopamine dynamics for learning and motivation DOI
Ali Mohebi,

Jeffrey R. Pettibone,

Arif Hamid

и другие.

Nature, Год журнала: 2019, Номер 570(7759), С. 65 - 70

Опубликована: Май 22, 2019

Язык: Английский

Процитировано

674

The Neuroscience of Drug Reward and Addiction DOI
Nora D. Volkow, Michael Michaelides, Rubén Baler

и другие.

Physiological Reviews, Год журнала: 2019, Номер 99(4), С. 2115 - 2140

Опубликована: Сен. 11, 2019

Drug consumption is driven by a drug's pharmacological effects, which are experienced as rewarding, and influenced genetic, developmental, psychosocial factors that mediate drug accessibility, norms, social support systems or lack thereof. The reinforcing effects of drugs mostly depend on dopamine signaling in the nucleus accumbens, chronic exposure triggers glutamatergic-mediated neuroadaptations striato-thalamo-cortical (predominantly prefrontal cortical regions including orbitofrontal cortex anterior cingulate cortex) limbic pathways (amygdala hippocampus) that, vulnerable individuals, can result addiction. In parallel, changes extended amygdala negative emotional states perpetuate taking an attempt to temporarily alleviate them. Counterintuitively, addicted person, actual associated with attenuated increase brain reward regions, might contribute drug-taking behavior compensate for difference between magnitude expected triggered conditioning cues experience it. Combined, these enhanced motivation "seek drug" (energized increases cues) impaired top-down self-regulation favors compulsive against backdrop emotionality interoceptive awareness "drug hunger." Treatment interventions intended reverse show promise therapeutic approaches

Язык: Английский

Процитировано

602

Active Inference, homeostatic regulation and adaptive behavioural control DOI Creative Commons
Giovanni Pezzulo,

Francesco Rigoli,

Karl Friston

и другие.

Progress in Neurobiology, Год журнала: 2015, Номер 134, С. 17 - 35

Опубликована: Сен. 12, 2015

We review a theory of homeostatic regulation and adaptive behavioural control within the Active Inference framework. Our aim is to connect two research streams that are usually considered independently; namely, associative learning theories animal behaviour. The former uses probabilistic (Bayesian) formulation perception action, while latter calls on multiple (Pavlovian, habitual, goal-directed) processes for control. offer synthesis these classical cast them as successive hierarchical contextualisations sensorimotor constructs, using generative models underpin Inference. This dissolves any apparent mechanistic distinction between optimization mediate or learning. Furthermore, we generalize scope by emphasizing interoceptive inference regulation. ensuing (or allostatic) perspective provides an intuitive explanation how priors act drives goals enslave emphasises embodied nature inference.

Язык: Английский

Процитировано

583

Rapid signalling in distinct dopaminergic axons during locomotion and reward DOI
Mark W. Howe, Daniel A. Dombeck

Nature, Год журнала: 2016, Номер 535(7613), С. 505 - 510

Опубликована: Июль 1, 2016

Язык: Английский

Процитировано

579

Ultrathin MXene‐Micropattern‐Based Field‐Effect Transistor for Probing Neural Activity DOI
Bingzhe Xu, Minshen Zhu,

Wencong Zhang

и другие.

Advanced Materials, Год журнала: 2016, Номер 28(17), С. 3333 - 3339

Опубликована: Фев. 29, 2016

A field-effect transistor (FET) based on ultrathin Ti3C2–MXene micropatterns is developed and utilized as a highly sensitive biosensor. The device produced with the microcontact printing technique, making use of its unique advantages for easy fabrication. Using MXene–FET device, label-free probing small molecules in typical biological environments fast detection action potentials primary neurons demonstrated. As service to our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may be re-organized online delivery, but not copy-edited or typeset. Technical support issues arising from (other than missing files) should addressed Please note: publisher responsible content functionality any Any queries content) directed corresponding author article.

Язык: Английский

Процитировано

545

Prolonged dopamine signalling in striatum signals proximity and value of distant rewards DOI
Mark W. Howe,

Patrick L. Tierney,

Stefan G. Sandberg

и другие.

Nature, Год журнала: 2013, Номер 500(7464), С. 575 - 579

Опубликована: Авг. 2, 2013

Язык: Английский

Процитировано

538

Neuroscience of apathy and anhedonia: a transdiagnostic approach DOI
Masud Husain, Jonathan P. Roiser

Nature reviews. Neuroscience, Год журнала: 2018, Номер 19(8), С. 470 - 484

Опубликована: Июнь 26, 2018

Язык: Английский

Процитировано

530

VTA dopaminergic neurons regulate ethologically relevant sleep–wake behaviors DOI
Ada Eban-Rothschild, Gideon Rothschild, William J. Giardino

и другие.

Nature Neuroscience, Год журнала: 2016, Номер 19(10), С. 1356 - 1366

Опубликована: Сен. 5, 2016

Язык: Английский

Процитировано

516