Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Cell, Год журнала: 2019, Номер 179(2), С. 312 - 339

Опубликована: Сен. 26, 2019

Язык: Английский

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Tau in physiology and pathology

Nature reviews. Neuroscience, Год журнала: 2015, Номер 17(1), С. 22 - 35

Опубликована: Дек. 3, 2015

Язык: Английский

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Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

Nature Reviews Drug Discovery, Год журнала: 2014, Номер 13(9), С. 655 - 672

Опубликована: Авг. 8, 2014

Язык: Английский

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The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

Neuron, Год журнала: 2014, Номер 82(4), С. 756 - 771

Опубликована: Май 1, 2014

Язык: Английский

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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

Nature, Год журнала: 2017, Номер 549(7673), С. 523 - 527

Опубликована: Сен. 1, 2017

Язык: Английский

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Tau-targeting therapies for Alzheimer disease

Nature Reviews Neurology, Год журнала: 2018, Номер 14(7), С. 399 - 415

Опубликована: Июнь 12, 2018

Язык: Английский

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Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

Neuron, Год журнала: 2014, Номер 82(6), С. 1271 - 1288

Опубликована: Май 22, 2014

Язык: Английский

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Frontotemporal dementia

The Lancet, Год журнала: 2015, Номер 386(10004), С. 1672 - 1682

Опубликована: Окт. 1, 2015

Язык: Английский

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Tau and neurodegenerative disease: the story so far

Nature Reviews Neurology, Год журнала: 2015, Номер 12(1), С. 15 - 27

Опубликована: Дек. 4, 2015

Язык: Английский

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Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies

Biomolecules, Год журнала: 2016, Номер 6(1), С. 6 - 6

Опубликована: Янв. 6, 2016

Abnormal deposition of misprocessed and aggregated proteins is a common final pathway most neurodegenerative diseases, including Alzheimer’s disease (AD). AD characterized by the extraneuronal amyloid β (Aβ) protein in form plaques intraneuronal aggregation microtubule-associated tau filaments. Based on biochemically diverse range pathological proteins, number approaches have been proposed to develop new potential therapeutics. Here we discuss some promising ones: inhibition phosphorylation, proteolysis aggregation, promotion intra- extracellular clearance, stabilization microtubules. We also emphasize need achieve full understanding biological roles post-translational modifications normal tau, as well molecular events responsible for selective neuronal vulnerability pathology its propagation. It concluded that answering key questions relationship between Aβ should lead better nature secondary tauopathies, especially AD, open therapeutic targets strategies.

Язык: Английский

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